An Analysis of Psychosocial Risk and Protective Factors: Accelerated Cognitive Aging and Mild Traumatic Brain Injury (MTBI) Among Retired NFL & Former NCAA Football Players

心理社会风险和保护因素分析：退役 NFL 加速认知老化和轻度创伤性脑损伤 (MTBI)

• 批准号: 9385633
• 负责人: Robert W. Turner
• 金额: $ 12.25万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-15 至 2017-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9385633
• 关键词: Address; Adult; Age; Aging; Aging-Related Process; Alzheimer' s Disease; Applications Grants; Area; Attitude; Awareness; Brain Concussion; Brain Injuries; Brain imaging; Cessation of life; Characteristics; Cognition; Cognitive; Cognitive aging; Collaborations; Control Groups; Data; Dementia; Demographic Factors; Disease; Elderly; Emergency department visit; Ethnography; Exercise; Exhibits; Focus Groups; Freedom; Frequencies; Gender; Goals; Health; Health Campaign; Health Care Costs; Health Status; Healthcare; Hospitalization; Individual; Injury; Instruction; Interview; Knowledge; Lead; Life; Life Cycle Stages; Manufactured football; Measures; Mediating; Medical; Medical Sociology; Memory impairment; Mental Depression; Mental Health; Mentored Research Scientist Development Award; Mentors; Methods; Michigan; Modeling; National Institute on Aging; Neurocognitive; Neurodegenerative Disorders; Pain; Pattern; Population; Portraits; Process; Psychosocial Assessment and Care; Psychosocial Factor; Psychosocial Stress; Public Health; Race; Reading; Recording of previous events; Reporting; Research; Research Personnel; Research Project Grants; Research Technics; Risk; Risk Factors; Scientist; Series; Severities; Stress; Surveys; Testing; Training; Training Activity; Training Support; United States; Universities; Variant; Veterans; Work; age related; biobehavior; biopsychosocial; brain health; career; career development; chronic depression; chronic pain; chronic traumatic encephalopathy; cognitive function; cohort; college; coping; cost; design; ethnographic method; evidence base; executive function; experience; fitness; health care availability; health care service utilization; health difference; health disparity; indexing; innovation; insight; male; men; mild cognitive impairment; mild traumatic brain injury; neuropsychiatry; operation; psychologic; psychosocial; racial and ethnic

Project Summary/Abstract: Robert W. Turner II is a Research Scientist in the Center on Biobehavioral Health Disparities Research at Duke University. He has training in medical sociology, ethnographic methods, and health disparities research. His previous and current work has exposed him to theoretical perspectives and empirical approaches pertinent to health disparity and aging research among men. The current proposal is for a five year Mentored Research Scientist Development Award (K01) from the National Institute on Aging for training and support that address gaps in his knowledge of biobehavioral factors underlying Alzheimer’s Disease (AD) dementia related mild traumatic brain injury mTBI and accelerated cognitive aging. In collaboration with his mentoring team (Drs. Tim Strauman, Keith Whitfield, and Toni Antonucci) he has developed a comprehensive training and research plan that will both fill in these knowledge gaps and prepare him for an independent research career. The overarching goal of his K01 is to gain expertise on the interrelationships between multiple measures of psychosocial and neurocognitive factors associated with AD dementia related accelerated cognitive aging, and serve as bridge for him to establish an independent investigator career in conducting biobehavioral health disparities research in adult male populations. To accomplish this goal, he proposes four career development activities and three research aims that combine instruction with established scholars in survey research techniques; formal coursework; participation in ongoing seminars at Duke and the University of Michigan; one-to-one directed readings with mentors; and finally, conducting of a “proof of concept study” from start to finish. Data will be collected using a mixed-method design that consists of a survey, focus groups, and in-depth interviews. The three research aims will enable him to integrate and apply knowledge gain through the proposed training activities by creating a more robust portrait of psychosocial protective and risk factors that may impact the long- term consequences of mTBI among men than previously possible. The approach used in this project will address; a) male vulnerabilities in predicting the impact of psychosocial factors on accelerated cognitive aging and b) how understandings of masculinity develop across and within groups in relationship to pain, injury, and brain health. This project will continue to build on insights he has gained through his examination of data from the Study of Retired NFL Players. By completing these aims, he will test important hypotheses and make substantial evidence based contributions to describing the process of dementia related cognitive accelerated aging resulting from mTBI. This proposal is relevant to public health because it will explore innovative approaches to address functional, cognitive, and psychosocial vulnerabilities in concussed men, and may ultimately reduce the risk of Chronic Traumatic Encephalopathy (CTE), and Alzheimer’s disease resulting from concussions. It will also inform an R-series grant proposal to study AD dementia related accelerated cognitive aging and brain imaging that Dr. Turner plans to submit in year 4 of the project.

项目摘要/摘要： 罗伯特·W·特纳二世 (Robert W. Turner II) 是杜克大学生物行为健康差异研究中心的研究科学家 他接受过医学社会学、民族志方法和健康差异研究方面的培训。 之前和当前的工作使他接触到了相关的理论观点和实证方法 男性健康差异和衰老研究当前的提案是一项为期五年的指导研究。 美国国家老龄化研究所颁发的科学家发展奖 (K01)，表彰其针对解决问题的培训和支持 他对阿尔茨海默病 (AD) 相关轻度痴呆症的生物行为因素的了解存在差距 与他的指导团队（蒂姆博士）合作，研究了创伤性脑损伤 mTBI 和加速认知老化。 Strauman、Keith Whitfield 和 Toni Antonucci）制定了全面的培训和研究计划。 这既可以填补这些知识空白，又可以为他的独立研究生涯做好准备。 他的 K01 的目标是获得有关心理社会和社会心理的多种测量之间相互关系的专业知识。 与 AD 痴呆相关的神经认知因素加速认知老化，并充当桥梁 他将建立一个独立的调查员职业生涯，进行生物行为健康差异研究 为了实现这一目标，他提出了四项职业发展活动和三项活动。 研究目标与正式学者的调查研究技术相结合； 课程作业；参加杜克大学和密歇根大学正在进行的一对一指导的研讨会； 与导师一起阅读；最后，从头到尾进行“概念验证研究”。 使用混合方法设计收集，包括调查、焦点小组和深度访谈。 三个研究目标将使他能够整合和应用通过拟议的培训获得的知识 通过对可能影响长期的社会心理保护和风险因素建立更强有力的描述来开展活动 该项目使用的方法将解决男性中 mTBI 的长期后果； a) 男性在预测心理社会因素对加速认知老化的影响方面存在弱点；b) 如何预测 群体之间和群体内部对男性气质的理解与疼痛、伤害和大脑健康有关。 该项目将继续建立在他通过检查研究数据获得的见解的基础上 退役 NFL 球员。通过完成目标，他将测试重要的假设并提供实质性证据。 基于对描述痴呆相关认知加速衰老过程的贡献 该提案与公共卫生相关，因为它将探索解决问题的创新方法。 脑震荡男性的功能、认知和社会心理脆弱性，并可能最终降低患脑震荡的风险 慢性创伤性脑病（CTE）和脑震荡引起的阿尔茨海默病也会。 告知 R 系列拨款提案，以研究 AD 痴呆相关的加速认知老化和脑成像 特纳博士计划在项目的第四年提交。