I.Iodonium Chemistry. II. Abiological Self-Assembly

I.碘化学。

• 批准号: 7344653
• 负责人: Peter J Stang
• 金额: $ 9.97万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-01-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7344653
• 关键词: Biological; Biosensor; Catalysis; Chemical Agents; Chemistry; Complex; Degenerative Disorder; Detection; Devices; Diagnostic; Disease; Drug Delivery Systems; Enzymes; Goals; Heart; Human; Investigation; Life; Medical; Membrane; Metals; Methodology; Methods; Microtubules; Molecular; Nanotechnology; Nucleic Acids; Object Attachment; Organism; Phospholipids; Play; Preparation; Prion Diseases; Procedures; Process; Production; Purpose; Research; Ribosomes; Role; Running; Science; Shapes; Structure; analytical tool; chemotherapy; combinatorial; design; frontier; improved; innovation; insight; molecular recognition; nanodevice; nanoscale; novel; programs; protein folding; self assembly; self organization; sensor; size

The long term objectives of this research are to develop efficient methods for the preparation of complex, nanoscale molecules with well defined shapes and sizes, by rational design and to provide new insights and gain a better understanding of recognition phenomena and self-assembly processes. Our specific aims are to investigate and understand host-guest interactions of self-assembled 3D molecular cages; prepare, characterize and explore the chemistry of novel, chiral 3D assemblies; explore and develop new ways of characterizing nanoscale supramolecular species; examine self-selection, self-recognition and dynamic phenomenain self-assembly; investigate hierarchical abiological self-assembly and screen for biological activity all new self-assembled supramolecular ensembles. We will use our recently developed abiological coordination driven, directional bonding approach in combination with new methodology and known analytical tools to achieve these goals. As a consequence, chemists will have conceptually new, innovative strategies for the formation of unique, complex, molecules that, in the long term, will facilitate the discovery and production of improved chemical agents and chemotherapy for the treatments of medical disorders. Moreover, also in the long run, this abiological self- assembly procedure will provide the means for the manufacturing of biomedical nanodevices (sensors for diagnostic purposes, new drug delivery systems, etc.) for the better detection and treatment of medical disorders. Likewise,the rationally designed, chiral, self-assembled molecular cages have the potential for selective substrate transformations (enzyme like catalysis) and to act as nanoreactors for unique molecular transformations. Self-assembly is at the heart of countless biological processesthat all living organisms, from the simplest to humans, depend upon. Protein folding, nucleic acid assembly and tertiary structures, ribosomes, phospholipid membranes, microtubules are but representative examples of self-assembly. Insights gained from the proposedabiological self-assembly studies will be applicable to a better and more complete understanding of the complex, not well understood biological self-assembly processes, such as protein folding, that play an important role in such degenerative diseases as Alzheimers, Creutzfeldt-Jakob, and prion diseases.

这项研究的长期目标是开发有效的方法来制备 通过合理设计，复杂的纳米级分子具有明确定义的形状和尺寸，并提供新的 洞察力并更好地了解识别现象和自组装过程。我们的 具体目的是调查和理解自组装3D分子的宿主 - 环相互作用 笼子；准备，表征和探索新型手性3D组件的化学反应；探索和发展 表征纳米级超分子物种的新方法；检查自我选择，自我认识和 动态现象自组装；调查层次生物学自组装和屏幕 生物活性所有新的自组装超分子合奏。 我们将使用我们最近开发的原始协调驱动的定向键合方法 结合新方法和已知的分析工具，以实现这些目标。结果， 化学家将拥有概念上的创新策略，以形成独特的，复杂的分子 从长远来看 用于治疗医学疾病的化学疗法。而且，从长远来看，这个生物学自我 组装程序将为生物医学纳米台词的制造提供手段（传感器的传感器 诊断目的，新药物输送系统等），以更好地检测和治疗医学 疾病。同样，理性设计的手性，自组装的分子笼有潜力 选择性底物转换（如催化酶），并充当独特分子的纳米反应器 转型。 自组装是无数生物学过程的核心，所有生物都是最简单的生物 对人类，依靠。蛋白质折叠，核酸组装和三级结构，核糖体， 磷脂膜，微管只是自组装的代表性例子。洞察力获得了 从提出的替代性自组装研究中，将适用于更好，更完整的 理解复合物，尚未充分理解的生物学自组装过程，例如蛋白质 折叠，该折叠在阿尔茨海默氏症，creutzfeldt-jakob和 病毒疾病。