ABIOLOGICAL SELF-ASSEMBLY

生物自组装

• 批准号: 7765584
• 负责人: Peter J Stang
• 金额: $ 29.6万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-01-01 至 2011-09-19
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7765584
• 关键词: Biological; Biological Process; Biosensor; Catalysis; Chemical Agents; Chemistry; Complex; Degenerative Disorder; Detection; Devices; Diagnostic; Disease; Drug Delivery Systems; Enzymes; Goals; Heart; Human; Investigation; Life; Medical; Membrane; Metals; Methodology; Methods; Microtubules; Molecular; Nanotechnology; Nucleic Acids; Organism; Phospholipids; Play; Preparation; Prion Diseases; Procedures; Process; Production; Research; Ribosomes; Role; Running; Science; Shapes; Structure; analytical tool; chemotherapy; combinatorial; design; frontier; improved; innovation; insight; molecular recognition; nanodevice; nanoscale; novel; programs; protein folding; self assembly; self organization; sensor

DESCRIPTION (provided by applicant): The long term objectives of this research are to develop efficient methods for the preparation of complex, nanoscale molecules with well defined shapes and sizes, by rational design and to provide new insights and gain a better understanding of recognition phenomena and self-assembly processes. Our specific aims are to investigate and understand host-guest interactions of self-assembled 3D molecular cages; prepare, characterize and explore the chemistry of novel, chiral 3D assemblies; explore and develop new ways of characterizing nanoscale supramolecular species; examine self-selection, self-recognition and dynamic phenomena in self-assembly; investigate hierarchical abiological self-assembly and screen for biological activity all new self-assembled supramolecular ensembles. We will use our recently developed abiological coordination driven, directional bonding approach in combination with new methodology and known analytical tools to achieve these goals. As a consequence, chemists will have conceptually new, innovative strategies for the formation of unique, complex, molecules that, in the long term, will facilitate the discovery and production of improved chemical agents and chemotherapy for the treatments of medical disorders. Moreover, also in the long run, this abiological self-assembly procedure will provide the means for the manufacturing of biomedical nanodevices (sensors for diagnostic purposes, new drug delivery systems, etc.) for the better detection and treatment of medical disorders. Likewise, the rationally designed, chiral, self-assembled molecular cages have the potential for selective substrate transformations (enzyme like catalysis) and to act as nanoreactors for unique molecular transformations. Self-assembly is at the heart of countless biological processes that all living organisms, from the simplest to humans, depend upon. Protein folding, nucleic acid assembly and tertiary structures, ribosomes, phospholipid membranes, microtubules are but representative examples of self-assembly. Insights gained from the proposed abiological self-assembly studies will be applicable to a better and more complete understanding of the complex, not well understood biological self-assembly processes, such as protein folding, that play an important role in such degenerative diseases as Alzheimers, Creutzfeldt-Jakob, and prion diseases.

描述（由申请人提供）：这项研究的长期目标是通过合理的设计来制定具有良好定义形状和大小的复杂纳米级分子的有效方法，并提供新的见解并获得对识别现象和自我组装过程的更好理解。我们的具体目的是调查和理解自组装的3D分子笼的宿主 - 宿主相互作用。准备，表征和探索新型手性3D组件的化学反应；探索和发展表征纳米级超分子物种的新方法；在自组装中检查自我选择，自我认识和动态现象；研究层次的生物学自我组装和生物活性的筛选，所有新的自组装超分子合奏。我们将使用我们最近开发的实物协调驱动的定向键合方法与新方法和已知的分析工具相结合来实现这些目标。结果，化学家将在概念上具有新的，创新的策略来形成独特的，复杂的分子，从长远来看，这些策略将有助于发现和生产改进的化学剂和对医疗疾病治疗的化学疗法。此外，从长远来看，这种生物学自组装程序将为生物医学纳米台词的生产提供手段（用于诊断目的的传感器，新药输送系统等），以更好地检测和治疗医疗疾病。同样，理性设计的手性，自组装的分子笼具有选择性底物转化（如催化酶）的潜力，并充当独特分子转化的纳米反应器。自组装是无数生物学过程的核心，从最简单到人类，所有生物都依靠。蛋白质折叠，核酸组装和三级结构，核糖体，磷脂膜，微管只是自组装的代表性例子。从提出的生物学自组装研究中获得的见解将适用于对复杂的，不充分理解的生物学自组装过程（例如蛋白质折叠）的更好，更完整的理解，这些过程在诸如阿尔茨海默氏症，克鲁特兹菲尔德·杰科布（Creutzfeldt-Jakob）等退行性疾病中起着重要作用。