Improving Waisman Center Animal Care Facility

改善魏斯曼中心动物护理设施

• 批准号: 7249201
• 负责人: ALBEE MESSING
• 金额: $ 70万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-15 至 2008-05-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7249201
• 关键词: Address; Animal Disease Models; Animal Experimentation; Animals; Appendix; Area; Behavior; Behavioral; Biohazardous Substance; Biological; Biological Sciences; Biomedical Research; Brain imaging; Budgets; Clinical; Clinical Research; Comprehensive Health Care; Condition; Crowding; Developmental Disabilities; Direct Costs; Elements; Embryo; Environment; Equipment; Facility Construction Funding Category; Faculty; Floor; Funding; Genetic; Gifts; Goals; Housing; Human; Interdisciplinary Study; Investigation; Laboratory Research; Mechanics; Medical Surveillance; Mission; Molecular and Cellular Biology; Mus; National Center for Research Resources; Nature; Neurodegenerative Disorders; Operative Surgical Procedures; Quarantine; Rattus; Research; Research Infrastructure; Research Personnel; Research Training; Rodent; Schedule; Schools; Science; Security; Services; Site; Source; Sterility; System; Text; Time; TimeLine; Universities; Vendor; Water; Wisconsin; animal care; animal facility; biological research; cost; density; drinking water; foot; gene therapy; improved; medical specialties; nerve stem cell; nervous system disorder; programs; repaired; research study; response; segregation

DESCRIPTION (provided by applicant): The Waisman Center at the University of Wisconsin-Madison is one of thirteen NIH-funded centers focused on developmental disabilities and neurodegenerative diseases, with a broad mission that encompasses research, training, and clinical activities. Since its inception in 1973 the Center has included an animal facility as a key element of its infrastructure and one of its scientific core services, yet little has been done to upgrade the facility to allow it to keep pace with the needs of current science. During the past six years both internal and external reviews identified critical shortcomings in our animal facility that needed to be addressed. Eighteen months ago both the main and backup cage-washers failed and could not be repaired, forcing evacuation of the entire facility. We have formulated a comprehensive plan for renovation, the overall cost of which is approximately $2.7 million (the majority paid for by university and gift funds). The goal of this renovation is to support Waisman Center investigators and affiliates by 1) increasing capacity in what is now a rodent-only facility, 2) improving barrier functions through increased use of microisolation, purchase and installation of biohazard hoods for selected areas, purchase and installation of an on-site autoclave for support of immunodeficient animals, and creation of dedicated quarantine space, 3) upgrading infrastructure by replacing outdated equipment for cage washing, installing, a disposable pouch system for supplying drinking water, installing ceilings to improve environmental control, and repairing flooring throughout, 4) improving security by installation of video surveillance systems and card-access controls, and 5) creating a suite of rooms optimized for long-term behavioral studies that is separate from the barrier portion of the facility.

描述（由申请人提供）：威斯康星大学麦迪逊分校的Waisman中心是13个由NIH资助的中心之一，专注于发育障碍和神经退行性疾病，具有广泛的使命，其中包含研究，培训，培训和临床活动。自1973年成立以来，该中心已将动物设施作为其基础设施的关键要素和科学核心服务之一，但是几乎没有采取任何措施来升级该设施以使其能够跟上当前科学的需求。在过去的六年中，内部和外部评论都确定了我们动物设施中需要解决的关键缺点。 18个月前，主要和备用笼式洗涤器都失败了，无法修复，迫使整个设施撤离。我们已经制定了一项全面的翻新计划，总成本约为270万美元（由大学和礼物基金支付的多数）。这种翻新的目的是通过1）通过增加啮齿动物的设施来支持Waisman中心的调查人员和分支机构，2）通过增加使用微溶解，购买和安装生物危害引擎盖来改善屏障功能，以购买和安装所选区域的空间，以支撑自动化的动物，并为不经意识的动物提供了备用，并为不经意识的动物提供了备用，并为不经意识的动物提供了备用，并为不经意识的动物提供了备用式官方官方，并为不经意识的动物提供了备用式官方官方，并为不经意识的动物提供了备用的不经意义的动物，又有不经意识的动物，造成了不经意识的动物，以及造型的不经意义的动物，造成了不经意识的动物，并建立了不合时宜的动物，并建立了不合适的动物，并建立了造成的越野范围。基础设施通过更换过时的设备进行笼子洗涤，安装，一种用于供应水的一次性袋系统，安装天花板以改善环境控制以及整个地板修理，4）通过安装视频监视系统和卡片访问控制以及5）为长期行为型的房间提供优化的室内式式式型号，从而改善安全性。