Attention Disorders Assessed By Event Related Brain Pote

通过事件相关的大脑电位评估注意力障碍

• 批准号: 7135731
• 负责人: Allan F. Mirsky
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7135731
• 关键词: attention; attention deficit disorder; auditory stimulus; behavior test; bioperiodicity; brain electrical activity; brain injury; clonidine; epilepsy; evoked potentials; head /neck injury; human subject; mental disorder diagnosis; neural information processing; partial seizure; pathologic process; patient oriented research; temporal lobe /cortex disorder

We have published in Biological Psychology a report of seasonal effects on the amplitude of cognitive ERP (Event-Related brain Potentials) components (Kosmidis et al., 1999). In preparation at this time are reports of the effects of clonidine (a norepinephrine blocker) on ERPs in normal subjects, as well as a comparison among normal controls and two groups of patients with seizure disorders. The latter study indicated that ERPs in patients with temporal lobe seizures resemble in most respects those seen in normal control subjects; in contrast, ERPs in patients with absence epilepsy show reduced amplitudes of cognitive components, especially P300 and slow wave. The differences were seen primarily in the processing of auditory signals. We are hoping to reactivate this project, in conjunction with colleagues at the Uniformed Services University of the Health Sciences. A manuscript describing the effects of closed head injuries on ERPs in attention-demanding tasks has been published by the journal Psychophysiology. The findings indicate that changes in the N200 component, concerned with identification and classification of stimuli, is altered in these patients, particularly in the auditory modality. These are presumably permanent changes in information processing, as the patients were on the average seven years post-injury. Dr. Duncan, a Guest Researcher, and I have also proposed a review of this general area, which is to appear in the International Journal of Psychophysiology. This review has been accepted for publication and will appear this year.

我们在生物心理学上发表了一份关于季节性对认知ERP振幅（事件相关的大脑电位）成分振幅的影响的报告（Kosmidis等，1999）。在此时的准备中，有报道称可乐定（去甲肾上腺素阻滞剂）对正常受试者ERP的影响，以及正常对照组和两组癫痫发作障碍患者之间的比较。后一项研究表明，颞叶癫痫发作患者的ERP在大多数方面类似于正常对照受试者中看到的ERP。相比之下，缺有癫痫患者的ERP显示出认知成分的振幅降低，尤其是P300和慢波。这些差异主要是在听觉信号的处理中。我们希望与统一的卫生科学服务大学的同事一起重新激活该项目。 《心理生理学》杂志发表了一种描述关注任务中闭合头部受伤对ERP的影响的手稿。研究结果表明，与刺激的识别和分类有关的N200成分的变化在这些患者中，特别是在听觉方式中发生了变化。这些可能是信息处理的永久变化，因为患者平均受伤后七年。客座研究员邓肯博士（Duncan）以及我还提出了对该一般领域的审查，该领域将出现在《国际心理生理学杂志》中。这篇审查已被接受供出版，今年将出现。