Molecular and Cellular Phenotyping (MCP) Core

分子和细胞表型分析 (MCP) 核心

• 批准号: 10714952
• 负责人: DON Michael WOJCHOWSKI
• 金额: $ 57.96万
• 依托单位: UNIVERSITY OF NEW HAMPSHIRE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10714952
• 关键词: Address; Adoption; Biocompatible Materials; Biomedical Engineering; Biomedical Research; Businesses; Centers of Research Excellence; Charge; Communities; Contract Services; Data; Data Analyses; Data Science Core; Dedications; Educational workshop; Ensure; Equipment; Experimental Designs; Fee Schedules; Funding; Future; Goals; Health; Human; Infrastructure; Institution; Interdisciplinary Study; Investments; Knowledge; Laboratories; Life Cycle Stages; Maintenance; Measures; Microscope; Molecular; Molecular Biology; Molecular and Cellular Biology; Phase; Phenotype; Productivity; Proteomics; Protocols documentation; Recovery; Reproducibility; Research; Research Infrastructure; Research Personnel; Research Support; Roentgen Rays; Schedule; System; Techniques; Training; Translating; Translational Research; Universities; base; cost; data management; data sharing; equipment acquisition; high resolution imaging; innovative technologies; instrument; instrumentation; mass spectrometer; nano; new technology; programs; research faculty; skills; ultra high resolution

PROJECT SUMMARY (MOLECULAR AND CELLULAR PHENOTYPING CORE) As a major research core component of UNH’s COBRE: Center of Integrated Biomedical and Bioengineering Research (CIBBR), the overall goal of the Molecular and Cellular Phenotyping (MCP) Core is to enable new technologies that translates rigorous multidisciplinary research into biomedical and bioengineering solutions while judiciously managing the MCP Core research infrastructure to ensure long-term sustainability. The Phase 2 objectives are to: (1) Appoint CIBBR faculty with the appropriate expertise to serve as Assistant Core Directors to the three MCP sub-cores (Cellular Biology, Molecular Biology, and BioAnalytics) to boost scientific guidance, core management, and user bases; (2) Acquire three major instruments (a super- high resolution Nikon STEDYCON module for the Nikon A1R confocal microscope, a Bruker timsTOF Pro2 LC-mass spectrometer system, and a Pavine nanoindenter) to expand research capacity and expertise in super-high resolution imaging, proteomics, and the mechano-deformability of biomaterials—all of central relevance to CIBBR investigators and the UNH and external research community; (3) Provide user training, workshops and support (in conjunction with the CIBBR Data Science Core) to encourage and enable the use of contemporary instrumentation and techniques, expand user bases, and ensure scientific rigor and reproducibility; (4) evolve and implement a business plan increases instrument utilization and integrates mechanisms for infrastructure sustainability of the MCP Research Core. Upon completion of the above objectives, the MCP Core will have advanced the capabilities, expertise, user base, management, and sustainability of the biomedical research infrastructure available to CIBBR, UNH and regional researchers. The MCP Core will also provide opportunities for CIBBR investigators to advance their research programs, while acquiring new skills and knowledge that bolster CIBBR’s impact and sustainability. Together, this will heighten the productivity of CIBBR-supported research programs and other MCP Core users, while effectively promoting the translation of research knowledge to enhance human health.

项目摘要（分子和细胞表型核心） 作为UNH的COBRE的主要研究核心组成部分：综合生物医学和 生物工程研究（CIBBR），分子和细胞表型（MCP）核心的总体目标是 为了启用新技术，将严格的多学科研究转化为生物医学和 生物工程解决方案同时明智地管理MCP核心研究基础设施以确保长期 可持续性。第2阶段的目标是：（1）任命CIBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBRTIS 三个MCP亚核（细胞生物学，分子生物学和生物分析）的核心主管 促进科学指导，核心管理和用户基础； 尼康A1R共聚焦显微镜的高分辨率Nikon StedyCon模块，Bruker Timstof Pro2 LC-MAS光谱仪系统和Pavine NanoIndenter），以扩大研究能力和专业知识 超高分辨率成像，蛋白质组学和中央生物材料的机械性可构性 与CIBBBR调查人员以及UNH和外部研究社区相关；（3）提供用户培训 研讨会和支持（与CIBBR数据科学核心核心核心核心核心核心核心核心核心核心核心核心核心核心核心核心核心核心核心核心核心核心核心核心核心核心核心核心核心核心核心核心核心核心核心核心核心核心核心核心核心核心核心核心核心核心核心核心核心核心核心核心核心核心核心核心核心核心核心核心核心核心核心核心核心核心 当代仪器和技术，扩大用户基础，并确保科学严谨性和 可重复性；（4）进化和实施业务计划，增加了工具的利用 MCP研究核心基础设施可持续性的机制。 在压缩上述目标后，MCP核心将提高功能，专业知识， Cibbr可用的生物医学研究基础设施的用户基础，管理和可持续性 和区域研究人员。 他们的研究计划，同时获得了增强CIBBR影响力的新技能和知识 可持续性。 MCP核心用户有效地促进了研究的翻译以增强人类健康。