Phase III COBRE in Stem & Progenitor Cell Biology and Regenerative Medicine

干细胞 III 期 COBRE

基本信息

批准号：
8514209
负责人：
DON Michael WOJCHOWSKI
金额：
$ 109.11万
依托单位：
MAINEHEALTH
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-01 至 2018-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8514209
关键词：
Advisory Committees Award Cell Culture Techniques Cell Energetics Cell Separation Cells Cellular biology Centers of Research Excellence Collaborations Core Facility Development Discipline Doctor of Philosophy Educational workshop Faculty Funding Gene Expression Genetic Goals Histopathology Human Pathology Investigation Journals Medical Research Medical center Mentors Metabolic Microscopy Molecular Analysis Mus National Institute of General Medical Sciences Nature Phase Phenotype Physiology Pilot Projects Positioning Attribute Publications Publishing Recruitment Activity Regenerative Medicine Research Research Infrastructure Research Institute Research Personnel Scientist Secure Seeds Series Services Staging Stem cells Students Training Translational Research United States National Institutes of Health Wing Work bone imaging member molecular phenotype mutant programs public health relevance stem success symposium

项目摘要

DESCRIPTION (provided by applicant): This is a proposal for continued NIH/NIGMS support for our COBRE in Stem & Progenitor Cell Biology and Regenerative Medicine as we transition from successful Phase-ll status to a critical stage of Phase-Ill development. Prime goals are: i) Continue to advance thematic, biomedically relevant discoveries in stem and progenitor cell biology; ii) Sustain and extend strong internal and external advisory committees and supporting mechanisms to expertly mentor investigators, fellows, students and core staff; iii) Implement a Pilot Project Program to springboard highly promising discoveries towards national funding and impacting publications; iv) Work with our highly supportive Medical Center and Research Institute to recruit additional strong COBRE Center investigators; v) Continue to sharpen the expertise, efficiency, utility and selfsustaining nature of our Center's Research Core Facilities. During Phase-ll, we have further advanced impacting discoveries in our discipline, published studies in excellent journals, mentored and advanced Center investigations, recruited strong new investigators, and demonstrated clear success in securing independent national funding. Gains in infrastructure and Institutional support also are significant. These include the construction of a new research wing, the ongoing recruitment of additional scientists, the advancement of existing core facilities, and the development of a highly needed Physiology Core. In Phase-Ill, the PI will be assisted administratively by a co-lnvestigator (L. Oxburgh, PhD, DVM COBRE member since 2005) and Program Coordinator (E. Jachimowicz). Our administrative core will implement a Pilot Project Program for outstanding seed investigations, and to advance new translational research opportunities; a core workshop and summer symposium in Stem & Progenitor Cell Biology; an invited seminar series; and the recruitment of a magnet clinician scientist. Core facilities also will be enhanced. The Molecular Phenotyping Core focuses on quantitative molecular analysis of gene expression and cellular microscopy. The Histopathology Core provides expert histological support plus new collaborations involving human pathology studies, and mouse genetic mutants. Our Progenitor Cell Analysis Core provides flow cytometric analyses, cell sorting, clonal cell analyses and stem/progenitor cell culture services. Our new Physiology Core will provide state-of-the-art metabolic phenotyping, skeletal imaging and cell energetic analyses. Specific plans towards Core and Center self-sufficiency post- Phase-Ill also are defined.

描述（由申请人提供）：这是我们从成功的相位LLL状态过渡到相位ILL开发的关键阶段的STEM和祖细胞生物学和再生医学的持续NIH/NIGMS支持的建议。主要目标是：i）继续在STEM和祖细胞生物学中推进主题，生物医学相关的发现； ii）维持和扩展强大的内部和外部咨询委员会，并向专业指导调查员，研究员，学生和核心人员提供支持机制； iii）实施一项试点项目计划，以对国家资助和影响出版物的弹簧板有希望的发现； iv）与我们高度支持的医学中心和研究所合作，招募其他强大的毛cen中心调查人员； v）继续提高我们中心研究核心设施的专业知识，效率，实用性和自我维持性质。在阶段ll期间，我们在学科，在优秀期刊上发表研究，指导和高级中心调查，招募了强大的新调查人员，并在获得独立国家资金方面取得了明显的成功。基础设施和机构支持的收益也很大。其中包括建设新的研究部，持续招募其他科学家，现有核心设施的发展以及发展急需的生理核心。在第相金中，PI将由共同vestigator在行政上进行协助（L. Oxburgh，PhD， DVM Cobre成员自2005年以来）和计划协调员（E. Jachimowicz）。我们的行政核心将实施一项试点项目计划，以进行杰出的种子调查，并促进新的转化研究机会； STEM＆祖细胞生物学中的核心研讨会和夏季研讨会；邀请的研讨会系列；以及招募磁铁临床医生。核心设施也将得到增强。分子表型核心侧重于基因表达和细胞显微镜的定量分子分析。组织病理学核心提供了专家组织学支持以及涉及人类病理学研究和小鼠基因突变体的新合作。我们的祖细胞分析核心提供流式细胞术分析，细胞分选，克隆细胞分析和茎/祖细胞培养服务。我们的新生理核心将提供最先进的代谢表型，骨骼成像和细胞能量分析。还定义了针对核心和中心自给自足的特定计划。