Structure and Function of Protein C

蛋白C的结构和功能

• 批准号: 9417849
• 负责人: JOHN H GRIFFIN
• 金额: $ 37.48万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-03-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9417849
• 关键词: Administrative Supplement; Animals; Blood; Cause of Death; Disasters; Dose; Exposure to; Human; Miniature Swine; Mus; Nuclear; Peptide Hydrolases; Plasma; Preparation; Property; Protein C; Radiation; Radioprotection; Structure; Structure-Activity Relationship; Variant; activated Protein C; protein function

This Administrative Supplement supports studies of the biologic activity of activated protein C (APC), along the lines of this R01 HL052246 project which is focused on the structure-activity relationships of protein C and APC. The Supplement will enable provision of well characterized preparations of wild type, plasma-derived APC for studies of the radioprotective activity of wild type APC in large animals, namely Gottingen minipigs.

本行政补充文件支持活化蛋白 C (APC) 的生物活性研究，以及 R01 HL052246 项目的系列，重点研究蛋白 C 的结构-活性关系和 装甲运兵车。该补充品将能够提供经过充分表征的野生型、血浆来源的制剂 APC 用于研究野生型 APC 在大型动物（即哥廷根小型猪）中的辐射防护活性。