Mentor Mothers: A Sustainable Family Intervention in South African Townships

导师母亲：南非乡镇的可持续家庭干预

• 批准号: 7168117
• 负责人: Mary Jane Rotheram-Borus
• 金额: $ 71.8万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-19 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7168117
• 关键词: AIDS; AIDS education /prevention; Africa; HIV infections; awareness; behavior therapy; behavioral /social science research tag; child rearing; child welfare; clinical research; communicable disease transmission; experimental designs; health behavior; human subject; human therapy evaluation; longitudinal human study; mentoring /mentor; mother /infant health care; mother child interaction; outcomes research; rural area; social support network; therapy compliance; therapy design /development; urban area; women' s health

DESCRIPTION (provided by applicant): South Africa has 5 million persons living with HIV (2.7 million women of childbearing age), the country with the most persons living with HIV (UNAIDS, 2004a). Fortunately, HIV testing and access to antiretroviral drugs (ARV) to prevent mother-to-child transmission (MTCT) of HIV from HIV+ pregnant women and their babies is being scaled up . Yet, 40.7% of pregnant women are HIV seropositive (HIV+) in townships such as those in the KwaZulu-Natal (KZN) Province of South Africa (Department of Public Health, South Africa, 2004). This project is primarily aimed at enhancing the adjustment of children of MLH by improving the health and mental health of MLH which benefits their children, as well as the MLH. The Mothers' Programmes (TMP) is a community based non-government organization, operating in South Africa including the Western and Eastern Cape, KZN, Mpumalanga and Northern Cape Provinces and two other African countries, Ethiopia and Botswana. TMP provides wrap-around preventive social support and educational services for MLH at MTCT clinic sites. The proposed project aims to transform the existing TMP into a theoretically-based, sustainable behavioral prevention program (the Mothers-To-Mothers [M2M] intervention) that will improve the adjustment of MLH and their babies. Rather than design an intervention that then must adapt itself to a delivery vehicle, we will take a delivery vehicle (TMP) and enhance its efficacy by creating the M2M intervention. We propose a two phase project over five years. In Phase 1 over the first year, we will finalize all measures, procedures, recruitment of staff, training protocols, and intervention manuals and strategies. In Phase 2, a quasi-experimental design will be implemented with 1632 MLH at 8 clinics (204 mothers/ clinic). Study clinics will be selected that provide environmental access to these services from two strata (large, peri-urban clinics [4 clinics] & small, rural clinics [4 clinics]). All MLH in 8 clinics (n = 1632) will be randomly assigned by clinic within strata to either: 1) standard care (SC), the health care that is delivered by the province; or 2) an enhanced care intervention condition (Mothers-to- Mothers [M2M]). The M2M intervention will be focused on caring for one's own health, parenting one's baby, maintaining mental health, and reducing transmission. The intervention's impact will be assessed over 15 months in a design that is a blend of an efficacy and effectiveness trial.

描述（由申请人提供）：南非有500万人患有艾滋病毒的人（270万育龄妇女），该国患有艾滋病毒的人最多（Unaids，2004a）。幸运的是，艾滋病毒测试并获得抗逆转录病毒药物（ARV），以防止艾滋病毒+孕妇及其婴儿的艾滋病毒母亲传播（MTCT）。然而，有40.7％的孕妇是南非夸祖鲁 - 纳塔尔省（KZN）省的乡镇中的艾滋病毒血清阳性（HIV+）（南非公共卫生部，2004年）。该项目主要旨在通过改善受益于孩子以及MLH的MLH的健康和心理健康来增强MLH儿童的调整。母亲计划（TMP）是一个基于社区的非政府组织，在南非运营，包括西开普，KZN，KZN，MPUMALANGA和北开普省以及其他两个非洲国家，埃塞俄比亚和博茨瓦纳。 TMP在MTCT诊所网站为MLH提供了环绕的预防性社会支持和教育服务。拟议的项目旨在将现有的TMP转变为基于理论上的可持续行为预防计划（母亲对母亲[M2M]干预），以改善MLH及其婴儿的调整。我们将乘坐送货工具（TMP）并通过创建M2M干预措施来增强其疗效，而不是设计干预措施，而不是必须适应运输工具。我们建议在五年内进行一个两阶段项目。在第一年的第一阶段中，我们将最终确定所有措施，程序，招聘人员，培训方案以及干预手册和策略。在第2阶段，将在8个诊所（204个母亲/诊所）上使用1632 MLH实施准实验设计。将选择研究诊所，以从两个地层（大型城市诊所[4个诊所]和小型农村诊所[4个诊所]提供环境访问这些服务。诊所将在8个诊所中的所有MLH（n = 1632）随机分配给：1）标准护理（SC），该省提供的医疗保健；或2）增强的护理干预条件（母亲到母亲[M2M]）。 M2M干预措施将集中在照顾自己的健康，育儿婴儿，维持心理健康并减少传播。干预措施的影响将在15个月内评估，该设计融合了功效和有效性试验。