UC Davis Mouse Cancer Imaging Program

加州大学戴维斯分校小鼠癌症成像项目

• 批准号: 6838939
• 负责人: Simon R Cherry
• 金额: $ 72.03万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6838939
• 关键词: bioimaging /biomedical imaging; biomedical equipment purchase; biomedical equipment resource; biomedical resource; cancer prevention; computed axial tomography; disease /disorder model; genetically modified animals; health science research; information systems; laboratory mouse; magnetic resonance imaging; model design /development; neoplasm /cancer; neoplasm /cancer classification /staging; neoplasm /cancer diagnosis; neoplasm /cancer therapy; optical tomography; particle accelerators; phantom model; positron emission tomography; radiochemistry; statistics /biometry; training

DESCRIPTION (provided by applicant): We propose to establish the UC Davis Mouse Cancer Imaging Program (MCIP), in which we integrate our expertise and resources in small animal imaging and mouse biology, and work closely with our leading cancer researchers to create new opportunities and directions for studying the basic biology, treatment and prevention of cancer. The program will be housed in our new small animal imaging center with equipment and expertise for PET, optical imaging and ultrasound, with MRI capability being provided by the immediately adjacent NMR facility. We propose to add a microCT scanner to the center. Mouse pathology will also form an integral part of the MCIP and will be incorporated through the Mouse Biology Program. The MCIP will initially support seven diverse base grants. One unique feature of the MCIP is that it will establish a satellite site at UMDNJ-Robert Wood Johnson Medical School as part of a demonstration project for expanding the reach of major imaging programs. The MCIP will also support three technology development projects focused on dynamic CT imaging in the mouse, a simplified PET scanner for the biology lab, and the development of methodology for quantitative, multimodality phantoms. In addition, our extensive funding base in small animal technology research will be leveraged for the MCIP. The MCIP is enhanced by a range of important ancillary resources, including a biomedical cyclotron and radiochemistry program, expertise in mouse handling and physiologic monitoring, core laboratories and expertise for creating genetically-engineered mouse models, and support for networking, data handling, databases, and biostatistics. We also propose a training program, with a practical imaging course, internships, and web-based material. Finally, the MCIP describes a clear structure for governance and for providing imaging-related services to cancer researchers at UC Davis and beyond.

描述（由申请人提供）：我们建议建立UC Davis小鼠癌症成像计划（MCIP），在该计划中，我们将我们的专业知识和资源整合到小动物成像和小鼠生物学中，并与领先的癌症研究人员紧密合作，以创造新的机会和方向，以研究癌症的基本生物学，治疗和预防癌症。该程序将安置在我们新的小型动物成像中心中，具有用于宠物，光学成像和超声波的设备和专业知识，MRI功能可由紧邻的NMR设施提供。我们建议在中心添加微型扫描仪。小鼠病理学还将形成MCIP的组成部分，并将通过小鼠生物学程序合并。 MCIP最初将支持七个不同的基础赠款。 MCIP的一个独特功能是，它将在Umdnj-Robert Wood Johnson医学院建立卫星站点，这是扩大主要成像计划范围的示范项目的一部分。 MCIP还将支持三个专注于小鼠动态CT成像的技术开发项目，生物学实验室的简化PET扫描仪以及用于定量，多模式幻影的方法论。此外，我们在小型动物技术研究中的大量资金基础将用于MCIP。 MCIP通过一系列重要的辅助资源来增强MCIP，包括生物医学回旋和放射化学计划，鼠标处理和生理监测方面的专业知识，核心实验室和创建遗传学工程鼠标模型的专业知识，以及对网络，数据处理，数据库，数据库和生物统计学的支持。我们还提出了一个培训计划，其中包括实用的成像课程，实习和基于网络的材料。最后，MCIP描述了治理的明确结构，并为加州大学戴维斯分校及其他地区的癌症研究人员提供与成像有关的服务。