Pittsburgh Mind-Body Center-II

匹兹堡身心中心-II

• 批准号: 6783032
• 负责人: KAREN MATTHEWS
• 金额: $ 71.01万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6783032
• 关键词: biomedical facility; clinical research; psychobiology; psychopathology; social psychology

DESCRIPTION (provided by applicant): Starting May 2000 we have been functioning as the Pittsburgh Mind-Body Center (PMBC-I) dedicated to: a) understanding shared psychological, behavioral, and psychobiological pathways that contribute to the onset of and recovery from diverse physical illnesses; and b) providing a training resource locally and nationally regarding mind-body relationships and health. We are now proposing to continue PMBC-II for an additional five years through the "Mind-Body Interactions and Health: Research Infrastructure Program (RFA OB-03- 004)". Based upon our accumulated research experience and accomplishments of the last 3 years, we intend to evaluate further the shared pathways model guiding our PMBC-I work in three ways: 1) unpacking key relevant concepts in the model, decomposing them and subjecting them to more micro-level analysis; 2) testing the influence of the life course on the pathways; and 3) extending the shared pathways model to diseases not already studied in PMBC-I. To carry out this work, we will have 5 research cores that will function in an orchestrated fashion: (A) Data Management and Statistical Resources; (B) Psychosocial and Health Behavior Assessment; (C) Sleep Assessment and Resources; and (D) Biological and Biomedical Measurement. To continue our research development and training mission, we will establish three infrastructure components: Innovative Pilot Research; Faculty Development; and Summer Institutes. Addressing the first aim of PMBC-II, an R01-like project (Stress and Brain Pathways to Reactivity) examines the central nervous system underpinning of cardiovascular reactivity to acute stress. The significance of PMBC-II rests upon the realization that many of the key mind-body concepts may be similar across diseases; that there is no home in mainstream health research for cross-disease research because of the specificity of most funding agencies; and that there is a potential for a multiplier effect from understanding shared pathways for explicating other diseases not directly part of the PMBC work. The infrastructure provided by PMBC-II will serve to integrate and promote research on the themes and research questions that the Center is designed to address. Support-in-kind from the host institutions will enable us to leverage the funds provided by the RFA to expand Center activities that would not otherwise be possible.

描述（由申请人提供）：从2000年5月开始，我们一直是匹兹堡心身中心（PMBC-I），专门用于：a）理解共同的心理，行为和心理生物学途径，有助于从多样化的身体疾病中恢复和恢复； b）在本地和全国范围内就思维关系和健康提供培训资源。我们现在建议通过“思维体互动与健康：研究基础设施计划（RFA OB-03- 004）”继续五年来继续PMBC-II。基于我们过去三年的积累研究经验和成就，我们打算通过三种方式评估指导我们的PMBC-I工作的共享途径模型：1）解开模型中的关键相关概念，将它们分解并使其对其进行更多的微观分析； 2）测试生命过程对道路的影响； 3）将共享途径模型扩展到PMBC-I中尚未研究的疾病。为了进行这项工作，我们将拥有5个研究核心，这些研究核心将以精心策划的方式运作：（a）数据管理和统计资源； （b）社会心理和健康行为评估； （c）睡眠评估和资源； （d）生物学和生物医学测量。为了继续我们的研究开发和培训任务，我们将建立三个基础设施组成部分：创新的试点研究；教师发展；和夏季研究所。针对PMBC-II的第一个目标，即R01样项目（反应性的压力和大脑途径），研究了心血管反应对急性应激的反应性的基础的中枢神经系统。 PMBC-II的意义取决于意识到，许多关键的思维体概念在各种疾病之间可能相似。由于大多数资金机构的特异性，主流健康研究没有主流健康研究。而且，从理解共享途径来阐明其他疾病而不是直接的PMBC工作中，可能会产生乘数效应。 PMBC-II提供的基础设施将用于整合和促进有关中心旨在解决的主题和研究问题的研究。主机机构的实物支持将使我们能够利用RFA提供的资金来扩大本来不可能的中心活动。