MIND-BODY-BEHAVIORAL MED CLINICAL TRIALS INFRASTRUCTURE

心身行为医学临床试验基础设施

• 批准号: 6783199
• 负责人: Thomas G Pickering
• 金额: $ 70.81万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6783199
• 关键词: behavioral medicine; biomedical facility; cardiovascular disorder; clinical research; disease /disorder etiology

DESCRIPTION (provided by applicant): We have identified 5 barriers, which we believe have impeded the impact of mind-body (behavioral) medicine on the general medical community. Each of these is a theme of our infrastructure proposal, and will be addressed by 4 Cores. The 1st theme concerns causal mechanisms: much of the evidence relating stress, cognitions, and emotions to chronic disease is based on observational studies. We propose that such mechanisms are better tested within interventional trials, and that the same mediators may be involved in different types of behavioral intervention. Accordingly, in Core A (Mechanisms) we will develop 2 test batteries, one evaluating behavioral factors (based on cognitive adaptation theory), and the other biological factors (based on the concept of allostatic load), and we will assess their causal status 3 ongoing behavioral clinical trials. The 2nd theme is lack of standardization of measures of psychological variables, which will be dealt with by the proposed battery in CoreA, and also a Cochrane review of other relevant assessment areas in Core D (Dissemination). The 3rd theme is health disparities and ethnicity. The prevalence and adverse consequences of most chronic diseases are worse in minority populations, and psychosocial factors are thought to play a major role. However, many of the instruments used to evaluate these have not been adequately tested in these populations. Core B (Minority Health Oversight) will address these issues. The 4th theme is information technology (Core C). Communication between patients and investigators or therapists is critical to any behavioral medicine endeavor, and we propose developing new techniques for data acquisition using tablet and hand-held computers, which should improve the quality of the data. In addition, behavioral medicine is interdisciplinary, and Core c will facilitate communications between investigators both within the Columbia community and outside it. The 5th theme is dissemination (Core D) - we believe that most medical practitioners are simply unaware of the existing achievements of behavioral medicine, and this Core will perform and disseminate Cochrane reviews of behavioral intervention trials and assessment instruments. The ultimate goal will be to make our findings available to 3 target audiences: 1) the network of investigators at Columbia; 2) the behavioral medicine community; and 3) the general medical community.

描述（由申请人提供）：我们已经确定了 5 个障碍，我们认为这些障碍阻碍了身心（行为）医学对一般医学界的影响。其中每一个都是我们基础设施提案的一个主题，并将通过 4 个核心来解决。第一个主题涉及因果机制：将压力、认知和情绪与慢性病相关的许多证据都基于观察性研究。我们建议在干预试验中更好地测试这种机制，并且相同的调解者可能参与不同类型的行为干预。因此，在核心 A（机制）中，我们将开发 2 个测试组，一个评估行为因素（基于认知适应理论），另一个评估生物因素（基于稳态负荷的概念），我们将评估它们的因果状态 3正在进行的行为临床试验。第二个主题是心理变量测量缺乏标准化，这将由 CoreA 中提议的电池组以及 Core D（传播）中其他相关评估领域的 Cochrane 审查来解决。第三个主题是健康差异和种族。大多数慢性病的患病率和不良后果在少数群体中更为严重，社会心理因素被认为起着重要作用。然而，许多用于评估这些的工具尚未在这些人群中进行充分的测试。核心 B（少数群体健康监督）将解决这些问题。第四个主题是信息技术（核心C）。患者与研究人员或治疗师之间的沟通对于任何行为医学工作都至关重要，我们建议开发使用平板电脑和手持式计算机进行数据采集的新技术，这应该可以提高数据的质量。此外，行为医学是跨学科的，Core c 将促进哥伦比亚社区内外研究人员之间的沟通。第五个主题是传播（核心D）——我们相信大多数医生根本不知道行为医学的现有成就，该核心将执行和传播行为干预试验和评估工具的Cochrane审查。 最终目标是将我们的研究结果提供给 3 个目标受众：1）哥伦比亚大学的研究人员网络； 2）行为医学界； 3）普通医学界。