MIND-BODY-BEHAVIORAL MED CLINICAL TRIALS INFRASTRUCTURE

心身行为医学临床试验基础设施

• 批准号: 6783199
• 负责人: Thomas G Pickering
• 金额: $ 70.81万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6783199
• 关键词: behavioral medicine; biomedical facility; cardiovascular disorder; clinical research; disease /disorder etiology

DESCRIPTION (provided by applicant): We have identified 5 barriers, which we believe have impeded the impact of mind-body (behavioral) medicine on the general medical community. Each of these is a theme of our infrastructure proposal, and will be addressed by 4 Cores. The 1st theme concerns causal mechanisms: much of the evidence relating stress, cognitions, and emotions to chronic disease is based on observational studies. We propose that such mechanisms are better tested within interventional trials, and that the same mediators may be involved in different types of behavioral intervention. Accordingly, in Core A (Mechanisms) we will develop 2 test batteries, one evaluating behavioral factors (based on cognitive adaptation theory), and the other biological factors (based on the concept of allostatic load), and we will assess their causal status 3 ongoing behavioral clinical trials. The 2nd theme is lack of standardization of measures of psychological variables, which will be dealt with by the proposed battery in CoreA, and also a Cochrane review of other relevant assessment areas in Core D (Dissemination). The 3rd theme is health disparities and ethnicity. The prevalence and adverse consequences of most chronic diseases are worse in minority populations, and psychosocial factors are thought to play a major role. However, many of the instruments used to evaluate these have not been adequately tested in these populations. Core B (Minority Health Oversight) will address these issues. The 4th theme is information technology (Core C). Communication between patients and investigators or therapists is critical to any behavioral medicine endeavor, and we propose developing new techniques for data acquisition using tablet and hand-held computers, which should improve the quality of the data. In addition, behavioral medicine is interdisciplinary, and Core c will facilitate communications between investigators both within the Columbia community and outside it. The 5th theme is dissemination (Core D) - we believe that most medical practitioners are simply unaware of the existing achievements of behavioral medicine, and this Core will perform and disseminate Cochrane reviews of behavioral intervention trials and assessment instruments. The ultimate goal will be to make our findings available to 3 target audiences: 1) the network of investigators at Columbia; 2) the behavioral medicine community; and 3) the general medical community.

描述（由申请人提供）：我们已经确定了5个障碍，我们认为这阻碍了心身（行为）医学对普通医学界的影响。这些都是我们基础设施提案的主题，将由4个核心解决。第一个主题涉及因果机制：与慢性病有关的压力，认知和情绪与慢性病有关的许多证据都是基于观察性研究。我们建议在介入试验中更好地测试此类机制，并且相同的调解人可能参与了不同类型的行为干预。因此，在核心A（机制）中，我们将开发2个测试电池，一个评估行为因素（基于认知适应理论）和其他生物学因素（基于同种异体负载的概念），我们将评估其因果状态3持续的行为临床试验。第二个主题是缺乏对心理变量度量的标准化，这将由提议的Corea中的电池处理，以及对Core D（传播）中其他相关评估领域的Cochrane审查。第三个主题是健康差异和种族。在少数族裔人群中，大多数慢性疾病的患病率和不利后果都更加严重，并且可以认为心理社会因素起着主要作用。但是，在这些人群中，用于评估这些仪器的许多仪器尚未得到充分的测试。核心B（少数民族健康的监督）将解决这些问题。第四个主题是信息技术（核心C）。患者与研究人员或治疗师之间的沟通对任何行为医学努力至关重要，我们建议使用平板电脑和手持计算机开发新技术来获取数据，这应该提高数据质量。此外，行为医学是跨学科的，核心C将有助于哥伦比亚社区和外部的调查人员之间的通信。第五个主题是传播（核心D） - 我们认为，大多数医生根本不知道行为医学的现有成就，而该核心将执行并传播对行为干预试验和评估工具的Cochrane评论。 最终目标是向3个目标受众提供我们的发现：1）哥伦比亚调查人员网络； 2）行为医学界； 3）普通医学界。