Effect of Angry Perseverative Cognition on Ambuatory BP

愤怒持续认知对动态血压的影响

• 批准号: 6816457
• 负责人: Thomas G Pickering
• 金额: $ 13.23万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-01 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6816457
• 关键词: angers; behavioral /social science research tag; behavioral medicine; blood pressure; clinical research; cognition; conditioning; disease /disorder etiology; environment associated hypertension; environmental stressor; human subject; longitudinal human study; multiple organ failure; angers; behavioral /social science research tag; behavioral medicine; blood pressure; clinical research; cognition; conditioning; disease /disorder etiology; environment associated hypertension; environmental stressor; human subject; longitudinal human study; multiple organ failure

Abstract We hypothesize that anger-induced perseverative cognition (or rumination) is a determinant of elevated blood pressure (BP) and such cognitions may be observed during post-anger recovery in the laboratory, and during ambulatory monitoring in the natural environment. Sustained BP elevation in turn confers independent risk for end organ damage (EOD). The main goal of the present research is to extend our understanding of the role angry perseverative cognition in sustained BP elevation by studying situational factors that influence the perseverative nature of these thoughts, in interaction with trait measures of rumination. Specifically, we will study the effects of a situational factor: an anger-recall provoking social encounter (via the Extended Type A Structured Interview; ESI) in interaction with trait tendencies to engage in perseverative angry cognitions, or rumination. We have found measures of this trait to be a useful predictor of behavioral rumination and poor BP recovery in the laboratory, and preliminary data indicate that persons who tend to engage in such cognitions tend to have higher ambulatory BP levels. We will use both a laboratory and an ambulatory BP monitoring component to study this type of cognition. A mixed design (1-between (level of trait rumination), 1- within (provocation or anger vs. neutral recall) is proposed. Participants with varying levels of trait rumination wear the ambulatory BP monitor during both a neutral and then again during an angerprovoking social interaction (one month apart, counterbalanced). During the laboratory portion of the session, which occurs early in the morning, we will assess BP continuously during pre-task, task, and post-task (15-minute recovery) periods; in addition, post-task cognitions will be assessed as well. Immediately following the recovery period, participants will wear an ambulatory BP monitor for the succeeding 24-hour period, and will complete an electronic diary, providing information concerning physical activity, mood, and cognitions. We hypothesize that we will observe (1) a main effect of the manipulation (anger-recall induction will produce greater post-task angry cognitions, poorer BP recovery assessed in the laboratory, and elevated ambulatory BP); (2) a main effect of the trait construct (persons who score high on trait rumination will tend to report more angry thoughts, and evidence higher ambulatory BP, than low trait ruminators); and (3) an interaction between these factors, such that participants who score higher on trait measures of rumination, and whose anger-recall is provoked, will evidence the highest frequency of angry cognition, the poorest BP recovery in the laboratory, and the highest ambulatory BP. Our long term aims are to understand one of the possible cognitive mechanisms that may be implicated in sustained BP elevations and eventual EOD.

抽象的 我们假设愤怒引起的持久性认知（或反思）是血压升高（BP）的决定因素，在实验室的居住后恢复期间以及在自然环境中的门诊监测期间，可以观察到这种认知。持续的BP高程反过来赋予了终端器官损伤（EOD）的独立风险。本研究的主要目的是通过研究影响这些思想持久性质的情境因素来扩展对持续BP升高中愤怒的持久性认知作用的理解，并与反省的特质量相互作用。具体而言，我们将研究一个情境因素的影响：一种激动的社会遭遇（通过扩展类型A结构化访谈； ESI）与特征趋势相互作用，以参与持久的愤怒认知或反思。我们发现，这种特征的措施是实验室行为反省和BP恢复不良的有用预测指标，初步数据表明，倾向于从事这种认知的人倾向于具有较高的门诊BP水平。我们将同时使用实验室和门诊BP监测组件来研究这种类型的认知。提出了一种混合设计（中间的1个之间（特质的反省水平），1-内（挑衅或愤怒与中性召回）。提出了特质反省不同水平的参与者在中性的过程中佩戴了卧床BP监视器，然后在愤怒发动机期间再次 社交互动（相距一个月，平衡）。在实验室部分 会议发生在清晨，我们将在任务，任务和任务后（恢复15分钟）期间连续评估BP；此外，还将评估任务后认知。恢复期结束后，参与者将在随后的24小时内穿着门诊BP监视器，并完成电子日记，提供有关体育活动，情绪和认知的信息。我们假设我们将观察到（1）操纵的主要作用（愤怒召集诱导将产生更大的任务后愤怒的认知，在实验室中评估的BP恢复较差，而卧床BP升高）； （2）特质构造的主要影响（在特质反思中得分很高的人将倾向于报告更多的愤怒思想，而证据比低性状反刍动物更高的表情）； （3）这些因素之间的相互作用，使得在反省的特征度量以及激怒其愤怒的参与者中得分更高，这将证明愤怒的认知的最高频率，实验室中最贫穷的BP恢复和最高的卧床BP。我们的长期目的是了解可能与持续的BP高程和最终EOD有关的可能的认知机制之一。