Effect of Angry Perseverative Cognition on Ambuatory BP

愤怒持续认知对动态血压的影响

• 批准号: 6816457
• 负责人: Thomas G Pickering
• 金额: $ 13.23万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-01 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6816457
• 关键词: angers; behavioral /social science research tag; behavioral medicine; blood pressure; clinical research; cognition; conditioning; disease /disorder etiology; environment associated hypertension; environmental stressor; human subject; longitudinal human study; multiple organ failure

Abstract We hypothesize that anger-induced perseverative cognition (or rumination) is a determinant of elevated blood pressure (BP) and such cognitions may be observed during post-anger recovery in the laboratory, and during ambulatory monitoring in the natural environment. Sustained BP elevation in turn confers independent risk for end organ damage (EOD). The main goal of the present research is to extend our understanding of the role angry perseverative cognition in sustained BP elevation by studying situational factors that influence the perseverative nature of these thoughts, in interaction with trait measures of rumination. Specifically, we will study the effects of a situational factor: an anger-recall provoking social encounter (via the Extended Type A Structured Interview; ESI) in interaction with trait tendencies to engage in perseverative angry cognitions, or rumination. We have found measures of this trait to be a useful predictor of behavioral rumination and poor BP recovery in the laboratory, and preliminary data indicate that persons who tend to engage in such cognitions tend to have higher ambulatory BP levels. We will use both a laboratory and an ambulatory BP monitoring component to study this type of cognition. A mixed design (1-between (level of trait rumination), 1- within (provocation or anger vs. neutral recall) is proposed. Participants with varying levels of trait rumination wear the ambulatory BP monitor during both a neutral and then again during an angerprovoking social interaction (one month apart, counterbalanced). During the laboratory portion of the session, which occurs early in the morning, we will assess BP continuously during pre-task, task, and post-task (15-minute recovery) periods; in addition, post-task cognitions will be assessed as well. Immediately following the recovery period, participants will wear an ambulatory BP monitor for the succeeding 24-hour period, and will complete an electronic diary, providing information concerning physical activity, mood, and cognitions. We hypothesize that we will observe (1) a main effect of the manipulation (anger-recall induction will produce greater post-task angry cognitions, poorer BP recovery assessed in the laboratory, and elevated ambulatory BP); (2) a main effect of the trait construct (persons who score high on trait rumination will tend to report more angry thoughts, and evidence higher ambulatory BP, than low trait ruminators); and (3) an interaction between these factors, such that participants who score higher on trait measures of rumination, and whose anger-recall is provoked, will evidence the highest frequency of angry cognition, the poorest BP recovery in the laboratory, and the highest ambulatory BP. Our long term aims are to understand one of the possible cognitive mechanisms that may be implicated in sustained BP elevations and eventual EOD.

抽象的 我们假设愤怒引起的持续认知（或沉思）是血压升高的决定因素，并且这种认知可以在实验室的愤怒后恢复过程中以及在自然环境中的动态监测过程中观察到。血压持续升高反过来又会带来终末器官损伤（EOD）的独立风险。本研究的主要目标是通过研究影响这些想法的持久性的情境因素以及与沉思特征测量的相互作用，来扩展我们对愤怒持久认知在持续血压升高中的作用的理解。具体来说，我们将研究情境因素的影响：引发愤怒回忆的社交遭遇（通过扩展 A 型结构化访谈；ESI）与进行持续愤怒认知或沉思的特质倾向相互作用。我们发现，在实验室中，这种特征的测量可以有效预测行为沉思和血压恢复不良，初步数据表明，倾向于进行此类认知的人往往具有较高的动态血压水平。我们将使用实验室和动态血压监测组件来研究这种类型的认知。提出了混合设计（1-之间（特征沉思水平）、1-内部（挑衅或愤怒与中性回忆）。具有不同特征沉思水平的参与者在中立期间佩戴动态血压监测仪，然后在中性回忆期间再次佩戴动态血压监测仪。激怒 社交互动（相隔一个月，平衡）。在实验室部分期间 会议在清晨进行，我们将在任务前、任务和任务后（15 分钟恢复）期间连续评估血压；此外，还将评估任务后认知。恢复期结束后，参与者将在接下来的 24 小时内佩戴动态血压监测仪，并完成电子日记，提供有关身体活动、情绪和认知的信息。我们假设我们将观察到（1）操作的主要效果（愤怒回忆诱导将产生更大的任务后愤怒认知，实验室评估的血压恢复较差，以及动态血压升高）； (2) 特质构建的主效应（与低特质沉思者相比，特质沉思得分高的人倾向于报告更多愤怒的想法，并且动态血压更高）； （3）这些因素之间的相互作用，例如在反刍特征测量中得分较高且愤怒回忆被激发的参与者将证明愤怒认知的频率最高，实验室中血压恢复最差，血压恢复最高。动态血压。我们的长期目标是了解可能与持续血压升高和最终 EOD 相关的认知机制之一。