Neural Substrates of Socioemotional Development

社会情绪发展的神经基础

• 批准号: 6751700
• 负责人: Ludise Malkova
• 金额: $ 10.04万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-06-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6751700
• 关键词: GABA receptor; Macaca mulatta; amygdala; animal developmental psychology; autism; axon; behavior test; behavioral /social science research tag; bicuculline; developmental neurobiology; emotions; experimental brain lesion; growth /development; histology; kynurenate; magnetic resonance imaging; muscimol; neuropharmacology; neuropsychology; social behavior

DESCRIPTION (provided by applicant): The research and career development plans proposed in this application will expand the candidate's expertise in neuropharmacology, normal and abnormal socioemotional development, epileptology, and magnetic resonance imaging (MRI) as applied to neurodevelopmental disorders such as autism, mental retardation, and cerebral palsy. The Research Plan proposed will take advantage of the recent evidence that dysfunction in medial temporal lobes, and the amygdala in particular, may be an etiological factor in autism. The goal of the application is to investigate the role of amygdala and its specific subdivisions for socioemotional behavior, and to identify the critical periods and neural triggers for developmental abnormalities in an animal model of autism. Specific Aim 1 concentrates on the effects of pharmacologically induced imbalances in neurotransmission in amygdala on social interactions in infant animals. Specific Aim 2 will compare the effects of drugs (as obtained in Aim 1) with the effects of discrete lesions of subregions of amygdala, damaged by axon-sparing lesions. Specific Aim 3 will evaluate the effects of early prolonged seizures, known to disrupt the function of amygdala and its projection network, on the neurodevelopmental behavioral outcomes. The experiments designed to pursue these aims will provide an opportunity for the candidate to gain both theoretical and practical expertise in the combined use of pharmacological, physiological, and MRI approaches to the study of the animal models. The candidate's background in behavioral research will be applied to the analyses of various components of socioemotional interactions of infant and juvenile animals in dyads and the assessment of their cognitive functions. The career development plan will facilitate a substantial shift in the candidate's research capabilities and scope, so that it will become possible for her to build an independent research program devoted to the identification of neural mechanisms underlying autism and other developmental disorders. The ability to evaluate the multifactorial impact of pharmacological interventions in animal models will prepare the candidate to pursue research on animal models of neurodevelopmental disorders and place her research skills in the context of pharmacology, epileptology, and physiology. Structured activities and short courses will guide the development of expertise in these areas necessary for the proposed studies as well as for the long-term career advancement of the candidate as a versatile neuroscientist.

描述（由申请人提供）：本申请中提出的研究和职业发展计划将扩大候选人在神经药理学，正常和异常的社会情感发展，癫痫学和磁共振成像（MRI）方面的专业知识，以应用于神经产生障碍，例如自闭症，心理阻碍，智力阻滞和塞雷布拉尔。 提出的研究计划将利用最近的证据，即颞内侧裂片的功能障碍，尤其是杏仁核，可能是自闭症的病因。 应用的目的是研究杏仁核及其在社会情感行为中的特定细分的作用，并确定自闭症动物模型中发育异常的关键时期和神经触发因素。 具体的目标1集中在杏仁核神经传递中药理诱导的失衡对婴儿动物社交相互作用的影响。 具体的目标2将比较药物的影响（如在目标1所获得的）与杏仁核子区域的离散病变的影响，杏仁核受损。 具体目标3将评估早期长期癫痫发作的影响，已知会破坏杏仁核及其投影网络对神经发育行为结果的影响。 旨在追求这些目标的实验将为候选人提供一个机会，以在药理学，生理和MRI方法联合使用以研究动物模型的研究方面获得理论和实用的专业知识。 候选人的行为研究背景将应用于对二元动物中婴儿和少年动物社会情感相互作用的各个组成部分的分析以及对其认知功能的评估。 职业发展计划将有助于候选人的研究能力和范围发生实质性转变，以便她有可能建立一个独立的研究计划，致力于识别自闭症和其他发育障碍的神经机制。 在动物模型中评估药理学干预措施的多因素影响的能力将使候选人做好对神经发育障碍动物模型的研究，并将其研究技能置于药理学，癫痫病和生理学的背景下。 结构化的活动和短期课程将指导拟议研究所必需的这些领域的专业知识以及候选人作为多功能神经科学家的长期职业发展。