Socioemotional Behavior and Amygdala-Based Circuitry in Primates

灵长类动物的社会情感行为和杏仁核回路

• 批准号: 8070497
• 负责人: Ludise Malkova
• 金额: $ 37.99万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-19 至 2013-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8070497
• 关键词: Accounting; Acute; Adolescent; Aggressive behavior; Agonist; Amygdaloid structure; Animal Model; Anti-Anxiety Agents; Anxiety; Anxiety Disorders; Attenuated; Autistic Disorder; Behavior; Behavioral; Bicuculline; Brain; Cell Nucleus; Diagnostic; Diazepam; Disinhibition; Dose; Emotional; Etiology; Evaluation; Fright; GABA Agonists; GABA Antagonists; Grooming; Human; Impairment; Impulsivity; Individual; Infusion procedures; Lesion; Mediating; Mental Depression; Midbrain structure; Monkeys; Mood Disorders; Muscimol; Network-based; Neurobiology; Non-Rodent Model; Outcome; Output; Pathology; Patients; Pattern; Play; Primates; Process; Psychopathology; Receptor Activation; Regulation; Research; Rewards; Rodent; Role; Sex Characteristics; Site; Social Behavior; Social Interaction; Social Phobia; Specificity; Stimulus; System; Tectum Mesencephali; Testing; Therapeutic; Therapeutic Intervention; Withdrawal; Work; affiliative behavior; base; bicuculline methiodide; emotional reaction; emotional stimulus; gamma-Aminobutyric Acid; interest; neuropsychiatry; nonhuman primate; novel; prevent; receptor; relating to nervous system; response; sex; social; superior colliculus Corpora quadrigemina

DESCRIPTION (provided by applicant): The proposal aims to identify the neural substrates in the brain that are responsible for abnormal socio-emotional behavior. This understanding is vital for developing both diagnostic and therapeutic approaches to identify and treat the abnormal brain circuitry in neuropsychiatric conditions such as affective and anxiety disorders. The field of social behavior research still lacks appropriate animal models for social pathology that leads to inappropriate aggression, social anxiety/phobias, social withdrawal/detachment, impulsivity, or defensiveness. The study of the neurobiology of social behavior in non-rodent models is especially promising since the impairment in social interactions and emotional processing generates symptomatology that resembles psychopathology observed in human patients. Moreover these studies will permit an analysis of social interactions at a level not feasible in rodents. Therefore, this work promises to substantially advance our understanding of the neural substrates of human social interactions in the norm and pathology with a special relevance to anxiety and depression. The proposed research seeks to investigate the novel components of the amygdala-based network that regulates socioemotional responses in order to account for imbalances that can give rise to psychopathology in the absence of structural lesions. The effects of the DLSC manipulations on the vulnerability to behavioral abnormalities evoked by disinhibition within nuclei of the amygdala will be analyzed to determine the role of DLSC in mediating and/or modulating the influence of the amygdala circuitry. An understanding of the functional relationship between the amygdala-derived and colliculus- derived regulation of defensive and aggressive emotional tone is expected to reveal novel targets for both etiology and therapeutic intervention for affective and anxiety disorders.

描述（由申请人提供）：该提案旨在识别大脑中导致异常社会情绪行为的神经基质。这种理解对于开发诊断和治疗方法来识别和治疗神经精神疾病（例如情感障碍和焦虑症）中的异常脑回路至关重要。社会行为研究领域仍然缺乏适当的社会病理学动物模型，这些模型会导致不当攻击、社交焦虑/恐惧症、社交退缩/疏离、冲动或防御。在非啮齿动物模型中进行社会行为的神经生物学研究特别有前途，因为社会互动和情绪处理的损害会产生类似于在人类患者中观察到的精神病理学的症状。此外，这些研究将允许对啮齿类动物无法实现的水平的社会互动进行分析。因此，这项工作有望大大增进我们对人类社会互动的神经基础的理解，这些神经基础与焦虑和抑郁特别相关。拟议的研究旨在调查基于杏仁核的网络的新组成部分，该网络调节社会情绪反应，以解释在没有结构性病变的情况下可能引起精神病理学的不平衡。将分析 DLSC 操作对杏仁核内去抑制引起的行为异常脆弱性的影响，以确定 DLSC 在介导和/或调节杏仁核电路影响中的作用。 了解杏仁核衍生和丘丘衍生的防御性和攻击性情绪调节之间的功能关系有望揭示情感和焦虑障碍的病因学和治疗干预的新目标。