Biostatistics, Bioinformatics and Environmental Sampling Core

生物统计学、生物信息学和环境采样核心

• 批准号: 9359961
• 负责人: Tasha E. Fingerlin
• 金额: $ 40.53万
• 依托单位: NATIONAL JEWISH HEALTH
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9359961
• 关键词: Air Pollution; Assessment tool; Asthma; Bioinformatics; Biological Assay; Biometry; Biostatistics Core; ChIP-seq; Clinical; Clinical Data; Clinical assessments; Collaborations; Communication; Complex; Consultations; Cost Savings; Data; Data Analyses; Data Quality; Data Set; Databases; Development; Development Plans; Documentation; Dust; Economic Burden; Emergency department visit; Ensure; Environmental Exposure; Epidemiology; Equipment; Exposure to; Fertilization; Genomics; Goals; Group Meetings; Hospitalization; Human; Human Resources; Individual; Infection prevention; Information Dissemination; Inhalation Exposure; Lead; Maintenance; Measurement; Measures; Methodology; Methods; Modeling; Molecular; Monitor; Pathway Analysis; Pathway interactions; Patients; Phenotype; Positioning Attribute; Procedures; Process; Protocols documentation; Questionnaires; Recording of previous events; Reporting; Research; Research Design; Research Personnel; Resource Sharing; Resources; Rhinovirus; Sampling; Security; Services; Standardization; Supervision; Techniques; Virus; Work; asthmatic; base; clinical phenotype; cost; data acquisition; data integration; data management; data sharing; design; experience; meetings; member; minimally invasive; molecular phenotype; multidisciplinary; novel strategies; organizational structure; personal exposure monitor; phenotypic data; pollutant; programs; quality assurance; skills; transcriptome sequencing; treatment response

Abstract The Biostatistics, Bioinformatics and Exposure Sampling (BBES) Core will provide an integrated approach to all projects with regard to 1) study design, 2) inhalation exposure assessment tools and measurement, 3) integration and management of phenotype, inhalation exposure and molecular data, and 4) biostatistical and bioinformatics analysis. By centralizing these activities, we expect that this multidisciplinary Core will increase the level of interaction among the projects and between projects and the Core. This strategy will allow us to coordinate study design and data management issues, leading to a more coherent approach to exposure assessment and data analysis as well as significant cost savings. The Core Director (Fingerlin) along with the inhalation exposure assessment lead (Thornburg) will supervise a team that is experienced in the conduct of studies involving the coordination of multidisciplinary teams in research. The team has the skill set required to manage complex issues of study design, epidemiology, genomics, broad quantitative methods, data management and inhalation exposure assessment. Interaction with Projects and Cores: The BBES Core will serve all four projects. Projects will receive assistance with Study Design from the Core including consultation with project PIs on methodological issues, at the initiation of a study, and ongoing consultation as the study progresses. Under the direction of Dr. Thornburg, the Inhalation Exposure Assessment responsibilities of the Core will be to 1) provide personal exposure monitors to Project 1, and 2) quantify exposures based on the filters taken from the personal monitors that will be utilized by all projects and 3) maintain comprehensive exposure data sets and transfer these data to NJH. The Core's Data Integration and Management responsibilities will serve all projects as well as the Administrative Core including: 1) management of data acquisition and transfer, 2) development and maintenance of research databases, and 3) ensuring data backup, storage, and security. The Core's Biostatistical and Bioinformatics Analysis responsibilities will include: 1) meeting with Project Directors to determine analysis needs, 2) conducting the biostatistical analyses, and 3) conducting bioinformatic analyses to summarize and interrogate the biostatistical results in terms of biologic pathways. Each project will benefit from the services provided to the other projects; the same experts will work on all three projects, which will ensure cross-fertilization of ideas and sharing of information. In addition, The BBES Core will interact closely with the Clinical Core to coordinate both exposure assessment and capture of clinical phenotype data. Finally, this Core will coordinate with the Administrative Core, as it provides the administrative and organizational structure to support this Program, and will receive direction from the Administrative Core and the Executive Committee. This Core will interact with the Administrative Core at monthly meetings with Project Leaders, and provide reports on its activities as needed otherwise. Members of the Core will attend the monthly Program meetings and will have individual monthly meetings with each project; these meetings will be staggered such that each week Dr. Fingerlin and appropriate Core investigators will meet with either an individual Project team or the entire Program. The products from the Core to the Program include 1) data integration and analysis scripts, comprehensive de- identified data sets, exposure monitor data, data analysis summaries with documentation, and participation in all aspects of dissemination. These products will assist all of the Projects and the Administrative Core in fulfilling their research, reporting and resource sharing goals and obligations.

抽象的 生物统计学、生物信息学和暴露采样（BBES）核心将提供一种综合方法 所有项目均涉及 1) 研究设计，2) 吸入暴露评估工具和测量，3) 表型、吸入暴露和分子数据的整合和管理，以及 4) 生物统计和 生物信息学分析。通过集中这些活动，我们预计这个多学科核心将增加 项目之间以及项目与核心之间的交互程度。这一战略将使我们能够 协调研究设计和数据管理问题，从而形成更加一致的暴露方法 评估和数据分析以及显着的成本节省。核心总监（Fingerlin）以及 吸入暴露评估负责人（Thornburg）将监督一支在执行以下方面经验丰富的团队： 涉及多学科团队协调研究的研究。该团队拥有所需的技能 管理研究设计、流行病学、基因组学、广泛的定量方法、数据的复杂问题 管理和吸入暴露评估。与项目和核心的交互：BBES 核心 将为所有四个项目提供服务。项目将获得核心研究设计方面的帮助，包括 在研究开始时就方法学问题与项目负责人进行协商，并持续进行协商 研究取得进展。在 Thornburg 博士的指导下，吸入暴露评估 核心的职责是 1) 为项目 1 提供个人暴露监测器，以及 2) 量化 曝光基于从所有项目将使用的个人监视器中获取的过滤器，以及 3) 维护全面的暴露数据集并将这些数据传输至 NJH。核心的数据集成和 管理职责将为所有项目以及行政核心服务，包括：1) 数据采集​​和传输的管理，2) 研究数据库的开发和维护，以及 3) 确保数据备份、存储和安全。 Core的生物统计和生物信息学分析 职责包括：1) 与项目总监会面以确定分析需求，2) 进行 生物统计分析，3) 进行生物信息学分析以总结和询问生物统计数据 生物学途径方面的结果。每个项目都将从向其他项目提供的服务中受益； 相同的专家将负责所有三个项目，这将确保思想的交叉传播和知识的共享 信息。此外，BBES 核心将与临床核心密切互动，以协调双方的接触 评估和捕获临床表型数据。最后，该核心将与行政部门协调 核心，因为它提供了支持该计划的行政和组织结构，并将收到 行政核心和执行委员会的指导。该核心将与 行政核心每月与项目负责人举行会议，并根据需要提供其活动报告 否则。核心成员将参加每月的计划会议，并每月举行个人会议 与每个项目举行会议；这些会议将错开进行，以便 Fingerlin 博士和 适当的核心调查员将与单个项目团队或整个计划会面。这 从核心到程序的产品包括1）数据集成和分析脚本，全面的de- 确定的数据集、暴露监测数据、带有文档的数据分析摘要以及参与 传播的各个方面。这些产品将协助所有项目和管理核心 履行其研究、报告和资源共享的目标和义务。