Nanophase Ceramics as Bone Implant Coatings

纳米相陶瓷作为骨植入涂层

• 批准号: 6793961
• 负责人: NADER M KALKHORAN
• 金额: $ 19.94万
• 依托单位: SPIRE CORPORATION
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-01 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6793961
• 关键词: X ray crystallography; atomic force microscopy; biomaterial compatibility; biomaterial development /preparation; biomaterial evaluation; biotechnology; bone development; bone prosthesis; dental implants; hydroxyapatites; laboratory rat; membrane fusion; nanotechnology; orthopedics; scanning electron microscopy; surface coating; yttrium

DESCRIPTION (provided by applicant): The overall objective of the proposed study is to create a new family of "smart" orthopedic and dental implant coating materials that enhance new bone formation over existing implants. "Smart" coating materials are necessary to selectively increase bone cell function while, at the same time, inhibit functions of competitive cells that lead to soft, instead of bony, tissue formation. Such osseointegration provides mechanical stability to an implant in situ, minimizes motion-induced damage to surrounding tissues, and is imperative for the clinical success of bone implants. In this manner, the health relatedness of the proposed project is to increase bonding between an implant and juxtaposed bone so that a patient who has received joint or dental replacement surgery may quickly return to a normal active lifestyle. Furthermore, the present proposal aims to increase the service-life of an orthopedic material by creating materials that form a strong, long lasting, bond with juxtaposed bone. The material proposed in the present study as a more effective orthopedic implant coating is: nanophase hydroxyapatite doped with yttrium. Nanophase ceramics are intriguing new material formulations since they possess grain sizes less than 100 nm in diameter. For this reason, nanophase ceramics simulate the grain size and topography of bone. Hydroxyapatite doped with yttrium coatings may increase initial absorption of calcium from serum leading to select protein adsorption to enhance bone cell function. This is speculated since yttrium has a high affinity for calcium. When not used as an implant coating, previous studies have determined that nanophase hydroxyapatite doped with yttrium increases bone cell function over existing hydroxyapatite formulations. The present study will build upon these results by using a novel technique to coat a currently utilized bone prosthetic material (titanium) with nanophase hydroxyapatite doped with yttrium. For Phase I studies, the ability of the titanium coated nanophase hydroxyapatite doped with yttrium to promote new bone synthesis and limit competitive cell function will be determined using in vitro cellular models. Specifically, osteoblast (bone-forming cells) and fibroblast (cells that have been associated with competitive soft tissue formation) function will be determined on the proposed coated materials. The specific aims of this proposal are therefore to combine previously designed materials that enhance new bone formation with a novel technique that will transform these bioactive materials into a practical bone prosthetic coating. Undoubtedly, design criteria used in the proposed study to investigate new coating techniques coupled with a new coating material could have great impact in the development of the "next-generation" of orthopedic implants with an improved ability to bind to juxtaposed bone.

描述（由申请人提供）：拟议研究的总体目标是创建一个新的“智能”骨科和牙科植入物涂料材料，从而增强了现有植入物的新骨形成。 “智能”涂料材料对于选择性地提高骨细胞功能是必需的，同时抑制了导致软体动物而不是骨质组织形成的竞争细胞的功能。这种骨整合为原位植入物提供了机械稳定性，可最大程度地减少运动引起的对周围组织的损害，并且对于骨骼植入物的临床成功至关重要。通过这种方式，拟议项目的健康相关性是增加植入物和并列骨之间的键合，以便接受关节或牙齿替代手术的患者可能会迅速恢复到正常的主动生活方式。此外，目前的提案旨在通过创建与并并列骨形成牢固，持久，粘合的材料来增加骨科材料的服务寿命。本研究中提出的作为一种更有效的骨科植入物涂料的材料是：掺有YTTrium的纳米相羟基磷灰石。纳米相陶瓷正在吸引新的材料制剂，因为它们的晶粒尺寸的直径小于100 nm。因此，纳米相陶瓷模拟了骨骼的晶粒尺寸和地形。用Yttrium涂层掺杂的羟基磷灰石可能会增加血清中钙的初始吸收，从而导致选择蛋白质吸附以增强骨细胞功能。这可以推测，因为Yttrium对钙具有很高的亲和力。当不用用作植入物涂料时，先前的研究已经确定，用Yttrium掺杂的纳米相羟基磷灰石会增加现有羟基磷灰石制剂的骨细胞功能。本研究将通过使用一种新型技术来基于这些结果，将当前利用的骨体材料（钛）与含有Yttrium掺杂的纳米相羟基磷灰石覆盖。对于I期研究，使用体外细胞模型确定钛涂层纳米相羟基羟基磷灰石掺杂YTTRIUM以促进新骨合成和限制竞争细胞功能的能力。具体而言，将在建议的涂层材料上确定成骨细胞（骨形成细胞）和成纤维细胞（与竞争性软组织形成相关的细胞）功能。因此，该提案的具体目的是将先前设计的材料与一种新型骨形成相结合，并将这些生物活性材料转化为实用的骨座涂层。毫无疑问，在拟议的研究中使用的设计标准与新的涂层材料一起研究新的涂料技术可能会对核植入物的“下一代”的发展产生巨大影响，其能力提高了与并置的骨骼结合的能力。

项目成果

Nanocrystalline hydroxyapatite/titania coatings on titanium improves osteoblast adhesion.

• DOI: 10.1002/jbm.a.31469
• 发表时间: 2008
• 期刊: Journal of biomedical materials research. Part A
• 作者: Michiko Sato;A. Aslani;Marisa A. Sambito;N. Kalkhoran;E. Slamovich;T. Webster

Increased osteoblast functions on undoped and yttrium-doped nanocrystalline hydroxyapatite coatings on titanium.

• DOI: 10.1016/j.biomaterials.2005.10.041
• 发表时间: 2006-04
• 期刊: Biomaterials
• 影响因子: 14
• 作者: Michiko Sato;Marisa A. Sambito;A. Aslani;N. Kalkhoran;E. Slamovich;T. Webster