Novel Treatment of Keloids and Hypertrophis Scars

疤痕疙瘩和增生性疤痕的新疗法

• 批准号: 6736994
• 负责人: BAKUL M BHATT
• 金额: $ 11.38万
• 依托单位: BIOMEDICAL DEVELOPMENT CORPORATION
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-06-18 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6736994
• 关键词: biomaterial development /preparation; biomaterial evaluation; biotechnology; clinical research; clinical trials; copolymer; emulsions; fluid; gas chromatography; high performance liquid chromatography; human subject; human therapy evaluation; immunologic assay /test; infrared spectrometry; keloid skin disorder; outcomes research; patient oriented research; polyvinyls; scanning electron microscopy; scars; solvents; surface coating; therapy design /development

DESCRIPTION (provided by applicant): Treatment of hypertrophic scars and keloids is time consuming, expensive, and has few consistently successful approaches. Hypertrophic scars and keloids are often treated with intralesional injection, pressure therapy, or excision. Unfortunately, these treatment modalities are invasive, painful, or inconvenient, and often unsuccessful. Silicone gel sheeting has been used successfully in the treatment of scarring, but the dressings can be difficult to affix and are associated with local side effects and cosmetic deficiencies that negatively impact compliance and patient satisfaction. The goal of this project is to demonstrate the feasibility of using a novel film forming technology as an alternative to silicone sheeting for the treatment of hypertrophic scars and keloids. This project offers an innovative polymer-based technology to overcome the limitations of silicone sheeting. The product is expected to be commercially successful based on its inherent low cost, ease of use, superior cosmetic attributes, and improved outcomes. The following specific aims will be pursued: Specific Aim 1. Formulate Coatings for the Treatment of Hypertrophic Scars and Keloids Specific Aim 2. Demonstrate Efficacy of Coatings in a Human Clinical Trial.

描述（由申请人提供）： 肥厚性疤痕和疤痕疙瘩的治疗既耗时又昂贵，而且几乎没有持续成功的方法。肥厚性疤痕和疤痕疙瘩通常通过病灶内注射、压力疗法或切除来治疗。不幸的是，这些治疗方式是侵入性的、痛苦的或不方便的，并且常常不成功。硅胶片已成功用于治疗疤痕，但敷料可能难以粘贴，并且会产生局部副作用和美容缺陷，从而对依从性和患者满意度产生负面影响。 该项目的目标是证明使用新型成膜技术替代硅胶片来治疗肥厚性疤痕和疤痕疙瘩的可行性。该项目提供了一种创新的聚合物技术来克服硅胶片的局限性。由于其固有的低成本、易用性、卓越的美容特性和改善的效果，该产品预计将获得商业上的成功。 我们将追求以下具体目标： 具体目标 1. 配制用于治疗肥厚性疤痕和瘢痕疙瘩的涂层 具体目标 2. 在人体临床试验中证明涂层的功效。