NOVEL SUBSTANCE TO AID IN THE REMINERALIZATION OF TEETH

有助于牙齿再矿化的新物质

• 批准号: 6073457
• 负责人: BAKUL M BHATT
• 金额: $ 10.7万
• 依托单位: BIOMEDICAL DEVELOPMENT CORPORATION
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-15 至 2002-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6073457
• 关键词: apatites; dental agent; dental caries; drug design /synthesis /production; fluoride ion; hydroxyapatites; laboratory rat; normal ossification; tooth

The overall goal of this project is to develop a novel substance as an aid in the remineralization of teeth. Dental caries continues to be a serious public health and economic burden in spite of the prevalence of worldwide exposure to fluoride. Even though the incidence of caries has dropped over the last twenty years, it remains a major problem as a recent study found that 45.3% of children in the U.S. ages 5 - 17 scored positive for caries in their permanent dentition. This study will evaluate the ability of a unique apatite-forming substance to stimulate the remineralization of teeth through the development of large crystallite structures. In order to demonstrate feasibility of this project, we will evaluate this unique technology to (1) determine its effect on the in vitro development of caries and (2) determine its effect on caries inhibition in an in vivo rodent model. PROPOSED COMMERCIAL APPLICATIONS: Over $37 billion was spent on dental services in the U.S. alone in 1992. Over half of this amount was spent on the prevention of tooth decay, single-tooth restoration, and the replacement of teeth. In addition to caries, this technology may have an impact on periodontal disease, osteoporosis, and alveolar bone loss.

该项目的总体目标是开发一种新物质来帮助牙齿再矿化。尽管氟化物暴露在全世界范围内普遍存在，但龋齿仍然是严重的公共卫生和经济负担。尽管龋齿的发病率在过去 20 年中有所下降，但它仍然是一个主要问题，因为最近的一项研究发现，美国 5 - 17 岁儿童中 45.3% 的恒牙列龋齿得分呈阳性。这项研究将评估一种独特的磷灰石形成物质通过大晶体结构的发育刺激牙齿再矿化的能力。为了证明该项目的可行性，我们将评估这种独特的技术，以（1）确定其对体外龋齿发展的影响，以及（2）确定其在体内啮齿动物模型中对龋齿抑制的影响。拟议的商业应用：仅 1992 年，美国就在牙科服务上花费了超过 370 亿美元。其中一半以上用于预防蛀牙、单牙修复和更换牙齿。除了龋齿之外，这项技术还可能对牙周病、骨质疏松症和牙槽骨流失产生影响。