A New Herbal Growth Factor for Periodontal Regeneration

用于牙周再生的新型草药生长因子

• 批准号: 6833917
• 负责人: HUI ZHAO
• 金额: $ 9.96万
• 依托单位: SUNNY BIODISCOVERY, INC.
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2004-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6833917
• 关键词: alternative medicine; angiogenesis; bone regeneration; chemical structure; computed axial tomography; fluorescence microscopy; growth factor; high performance liquid chromatography; laboratory mouse; medicinal plants; morphometry; nuclear magnetic resonance spectroscopy; periodontitis; periodontium; plant extracts; protease inhibitor; skull; technology /technique development

DESCRIPTION: Periodontitis is the major cause of teeth motility and loss. Twenty percent of adult Americans suffer severe periodontitis, resulting in destruction of the supporting structures of teeth, including the alveolar bone. Periodontal surgery can slow the progression of the disease, but is costly, limited by contraindications, often requires repeated treatment and does not regenerate lost periodontal structures. To that end, several regenerative modalities have been employed. Of particular interest has been the use of biologicals, such as bone morphogenetic proteins and angio-stimulatory growth factors (e.g., bFGF). Unfortunately, these stimulators undergo proteolysis, and cannot be readily maintained in treatment sites at therapeutic levels. Here, we propose to test the regenerative capabilities of SBD.4-a novel stable, non-proteinaceous molecule isolated from a medicinal plant, strongly stimulating angiogenesis, fibroblast and osteoblast growth and collagen synthesis-the activities needed for periodontal regeneration. We will further characterize this new compound and will test it in the murine calvarial bone regeneration model, which is particularly suitable for pilot testing of potential anti-periodontitis therapies. Targeted endpoint will be increased bone regeneration by at least 30% as measured by micro-computerized tomography and histomorphometry. If successful, this project will result in a preclinical drug candidate for treatment of periodontal disease.

描述：牙周炎是牙齿运动和损失的主要原因。 20％的成年美国人患有严重的牙周炎，导致牙齿的支撑结构（包括肺泡骨）破坏。牙周手术可以减慢疾病的进展，但昂贵，受禁忌症的限制，通常需要重复治疗，并且不会再生牙周结构损失。为此，已经采用了几种再生方式。特别令人感兴趣的是生物学的使用，例如骨形态发生蛋白和血管刺激生长因子（例如BFGF）。不幸的是，这些刺激剂会经历蛋白水解，并且在治疗水平的治疗部位不容易维持。在这里，我们建议测试从药用植物中分离出来的SBD.4-sbd.4-新型稳定的非蛋白质分子，强烈刺激了血管生成，成纤维细胞和成骨细胞生长和胶原蛋白 - 牙周再生所需的活动。我们将进一步表征这种新化合物，并将在鼠钙颅骨再生模型中进行测试，该模型特别适合试用潜在的抗周围炎疗法。通过微型计算层析成像和组织形态测定法测量，靶向端点将使骨再生至少增加30％。如果成功，该项目将导致临床前药物治疗牙周疾病。

项目成果

Effect of SBD.4A--a defined multicomponent preparation of Angelica sinensis--in periodontal regeneration models.

SBD.4A（一种确定的当归多组分制剂）在牙周再生模型中的作用。

• DOI: 10.1002/ptr.2421
• 发表时间: 2008
• 期刊: Phytotherapy research : PTR
• 作者: Zhao,Hui;Alexeev,Alexei;Sharma,Vrushali;Guzman,LorenzoDaveT;Bojanowski,Krzysztof
• 通讯作者: Bojanowski,Krzysztof