DRUGS OF ABUSE AND HUMAN AGGRESSIVE BEHAVIOR

药物滥用和人类攻击行为

• 批准号: 6612862
• 负责人: Don R Cherek
• 金额: $ 29.72万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-09-01 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6612862
• 关键词: aggression; anticonvulsants; antisocial personality; behavior test; behavioral /social science research tag; benzodiazepines; clinical research; conduct disorder; drug interactions; gamma aminobutyrate; human subject; lorazepam; muscle relaxants; neurotransmitter agonist; neurotransmitter antagonist; psychopharmacology; violence

Aggressive behavior puts individuals at high risk for a variety of antisocial behaviors in addition to substance abuse, and such aggressive behavior is a major component of the diagnostic criteria for childhood conduct disorder. Adolescents and adults with a history of childhood conduct disorder typically continue to engage in antisocial behavior in adulthood, and are at the highest risk for substance abuse and criminal activity. For the past twenty years, the investigator's laboratory has been engaged in the study of human aggressive responding under controlled conditions. They have developed a laboratory procedure, the Point Subtraction Aggression Paradigm (PSAP), which is now used in several laboratories in and outside the U.S. Since aggressive behavior is intimately involved in the risk for substance abuse, it is important to investigate some of the basic biological mechanisms that may regulate this behavior. Five GABA related drugs will be studied to determine their effects on aggressive behavior in two different populations of subjects: 1) Subjects with a history childhood conduct disorder (CD) + current antisocial personality disorder (ASPD), probably the highest risk population and; 2) Matched controls. The drugs to be employed are: baclofen a GABA B agonist, tiagabine a selective GABA reuptake inhibitor, lorazepam a GABA A agonist, flumazenil a specific GABA A antagonist and gabapentin a GABA releasing agent. The proposed research will provide information about the role of GABA in human aggression. Understanding the different biological factors involved in human aggression may lead to intervention/prevention strategies that will reduce the risk for substance dependence among high-risk populations.

侵略性行为使个人面临各种各样的风险 除滥用药物外，反社会行为和如此积极的行为 行为是儿童行为诊断标准的主要组成部分 紊乱。有儿童行为障碍史的青少年和成年人 通常在成年期继续从事反社会行为 药物滥用和犯罪活动的最高风险。过去二十 多年来，研究人员的实验室从事人类研究 在受控条件下进行积极反应。他们已经开发了 实验室程序，点减法侵略范式（PSAP） 由于积极进取 行为与滥用药物的风险密切相关，这是 重要的是研究一些可能的基本生物学机制 调节这种行为。将研究五种与GABA相关的药物以确定 它们对两个不同受试者人群的侵略行为的影响： 1）患有儿童行为障碍（CD） +电流反社会的受试者 人格障碍（ASPD），可能是风险最高的人群，； 2） 匹配的控件。要使用的药物是：baclofen a gaba b激动剂， tiagabine A选择性GABA再摄取抑制剂，Lorazepam a Gaba a激动剂， flumazenil特定的GABA拮抗剂和加巴喷丁释放剂。 拟议的研究将提供有关GABA在人类中作用的信息 侵略。了解人类涉及的不同生物学因素 侵略可能导致干预/预防策略，以减少 高风险人群之间物质依赖的风险。