Essential Siemens Prisma Fit Upgrade for the University of Kentucky 3T Research Scanner

肯塔基大学 3T 研究扫描仪的基本西门子 Prisma Fit 升级

• 批准号: 9274596
• 负责人: Charles Dennis Smith
• 金额: $ 81.34万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-03-21 至 2018-03-20
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9274596
• 关键词: Animals; Applications Grants; Biomedical Research; Brain; Clinical; Collaborations; Computer Systems; Computers and Advanced Instrumentation; Environment; Equipment; Funding; Human Resources; Image; Kentucky; Magnetic Resonance Imaging; Maintenance; Modernization; Neurosciences; Neurosciences Research; Noise; Occupational activity of managing finances; Research; Research Infrastructure; Research Personnel; Signal Transduction; Structure; System; United States National Institutes of Health; Universities; computer program; high resolution imaging; improved; insight; instrument; magnetic field; prisma; programs; radiofrequency; spectroscopic imaging; white matter

This is a multiuser equipment grant application for a Siemens Prisma Fit upgrade to the existing Magnetom 3T TIM Trio MR scanner in the MRISC at the University of Kentucky. Funding to support this upgrade is being requested because of the significant advantages of the Prisma system for biomedical research particularly for a group of productive, NIH-funded investigators involved in neuroscience research. The Prisma system will be integral to maintaining and expanding the research program of this group of investigators. Among the many advantages of the new instrument the most significant include the improved magnetic field gradient system, (higher amplitude and improved duty cycle) which will enable studies of white matter structure in a detail which is unavailable on the current Trio system. The upgrade will include an improved radiofrequency (RF) system which includes a doubling of the number of RF receive channels. The resulting higher signal-to-noise and higher resolution images will enable newer insights into brain degeneration and remodeling. The parallel transmit system on the Prisma will improve the homogeneity of excitation and enable 2D selective excitation for reduced FOV imaging. A state-of-the-art computer system and programming environment also included in the upgrade will facilitate enhanced collaboration with other biomedical researchers and a path to regular system modernization. The PI and multiple co-PIs, which form the Major Users Group on this application, have funded programs ranging from fundamental studies in neuroscience to clinical neuroscience research programs. Their research will significantly benefit from this advanced instrumentation which is not available at the University or elsewhere in the State. Through the University’s Magnetic Resonance Imaging and Spectroscopy Center which also manages a small animal, high field MR imager, the infrastructure (including space, financial management, routine maintenance, technical support and personnel) exists to rapidly bring the new scanner on line when funding becomes available and to continue to develop its capabilities to aid biomedical research.

这是一份多用户设备拨款申请，用于将西门子 Prisma Fit 升级到 肯塔基大学 MRISC 中现有的 Magnetom 3T TIM Trio MR 扫描仪。 由于该技术的显着优势，正在请求资金支持此次升级。 用于生物医学研究的 Prisma 系统，特别是针对一组由 NIH 资助的富有成效的研究人员 Prisma 系统将成为参与神经科学研究的研究人员的一部分。 维持和扩大这组研究人员的研究计划。 在新仪器的众多优点中，最显着的包括 改进的磁场梯度系统（更高的振幅和改进的占空比），这将 能够对白质结构进行详细研究，这是当前 Trio 无法实现的 升级将包括改进的射频（RF）系统，其中包括一个 RF 接收通道数量加倍，从而实现更高的信噪比。 高分辨率图像将使人们能够对大脑退化和重塑有新的认识。 Prisma 上的并行传输系统将提高激励的均匀性并实现 2D 用于缩小视场成像的选择性激发最先进的计算机系统和 升级中还包括编程环境，将有助于加强协作 与其他生物医学研究人员合作以及常规系统现代化的途径。 构成此应用程序主要用户组的多个共同 PI 已资助项目 范围从神经科学的基础研究到临床神经科学研究项目。 他们的研究将大大受益于这种无法获得的先进仪器 在大学或州内其他地方通过大学的磁共振。 成像和光谱中心还管理小动物、高场 MR 成像仪、 基础设施（包括空间、财务管理、日常维护、技术 支持和人员）的存在，以便在资金到位时快速使新扫描仪上线 并继续发展其能力以协助生物医学研究。

项目成果

Effect of Blood Flow Restriction Training on Quadriceps Muscle Strength, Morphology, Physiology, and Knee Biomechanics Before and After Anterior Cruciate Ligament Reconstruction: Protocol for a Randomized Clinical Trial.

血流限制训练对前十字韧带重建前后股四头肌肌肉力量、形态、生理学和膝关节生物力学的影响：随机临床试验方案。

• 发表时间: 2019
• 影响因子: 3.2
• 作者: Erickson, Lauren N;Lucas, Kathryn C Hickey;Davis, Kylie A;Jacobs, Cale A;Thompson, Katherine L;Hardy, Peter A;Andersen, Anders H;Fry, Christopher S;Noehren, Brian W
• 通讯作者: Noehren, Brian W

Neuroplasticity in Corticolimbic Brain Regions in Patients After Anterior Cruciate Ligament Reconstruction.

前十字韧带重建后患者皮质边缘大脑区域的神经可塑性。

• 发表时间: 2021-04-01
• 作者: Baez, Shelby;Andersen, Anders;Andreatta, Richard;Cormier, Marc;Gribble, Phillip A;Hoch, Johanna Marie
• 通讯作者: Hoch, Johanna Marie

Resting state functional connectivity responses post-mild traumatic brain injury: a systematic review.

轻度创伤性脑损伤后静息态功能连接反应：系统评价。

• 发表时间: 2021-09-19
• 影响因子: 1.9
• 作者: Morelli, Nathan;Johnson, Nathan F;Kaiser, Kimberly;Andreatta, Richard D;Heebner, Nicholas R;Hoch, Matthew C
• 通讯作者: Hoch, Matthew C

Multi-vendor multi-site T1ρ and T2 quantification of knee cartilage.

膝关节软骨的多供应商多部位 T1α 和 T2 量化。

• DOI: 10.1016/j.joca.2020.07.005
• 发表时间: 2020-12
• 期刊: Osteoarthritis and cartilage
• 影响因子: 7
• 作者: Kim J;Mamoto K;Lartey R;Xu K;Nakamura K;Shin W;Winalski CS;Obuchowski N;Tanaka M;Bahroos E;Link TM;Hardy PA;Peng Q;Reddy R;Botto-van Bemden A;Liu K;Peters RD;Wu C;Li X
• 通讯作者: Li X