Role of BCMA in Normal Plasma Cell Development

BCMA 在正常浆细胞发育中的作用

• 批准号: 6937173
• 负责人: JAIME R. DARCE
• 金额: $ 3.78万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-15 至 2006-07-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6937173
• 关键词: B cell receptor; B lymphocyte; CD40 molecule; biological signal transduction; cell age; cell cycle; cell differentiation; cell growth regulation; cytokine receptors; developmental genetics; enzyme linked immunosorbent assay; gel mobility shift assay; gene expression; human tissue; plasma cells; predoctoral investigator; receptor expression; tumor necrosis factor alpha

DESCRIPTION (provided by applicant): A great deal of experimental effort has been directed toward understanding various aspects of B cell development. Early studies focused on the B cell receptor as the primary signal required for cell maturation, differentiation, and prolonged survival. Subsequent investigation has revealed that members of the tumor necrosis factor superfamily are required for complete development of B cells. Recently, TNF ligands, BLyS and APRIL, and TNF receptors, BAFF-R, BCMA, and TACI have been intensively studied because of evidence implicating them in normal B cell development. However, the primary focus of these studies has been in defining the role these molecules play in early B cell development. Thus, considerably less information is available concerning their role in later stages of B cell differentiation. Our preliminary data demonstrate that expression of B cell maturation antigen (BCMA) increases during B cell differentiation into antibody secreting cells. The precise role that BCMA plays during this process remains to be elucidated. Therefore, this proposal will specifically investigate the signals that regulate BCMA expression, the signals delivered by BCMA, and the role of BCMA in human B cell differentiation.

描述（由申请人提供）：大量的实验努力是针对理解B细胞开发的各个方面的。早期研究集中在B细胞受体上是细胞成熟，分化和延长生存期所需的主要信号。随后的研究表明，肿瘤坏死因子的成员超级家族是B细胞完全发育所必需的。最近，由于有证据表明它们参与正常B细胞​​的发育，因此对TNF配体，BLYS和APRIN以及TNF受体，BAFF-R，BCMA和TACI进行了深入研究。但是，这些研究的主要重点是定义这些分子在早期B细胞发育中所起的作用。因此，关于它们在B细胞分化后期的作用的信息较少。我们的初步数据表明，B细胞成熟抗原（BCMA）的表达在B细胞分化为抗体分泌细胞中增加。 BCMA在此过程中扮演的确切作用尚待阐明。因此，该建议将特别研究调节BCMA表达，BCMA传递的信号以及BCMA在人B细胞分化中的作用的信号。