CORE--TISSUE PROCUREMENT AND BANKING FACILITY

核心——组织采购和银行设施

• 批准号: 6481855
• 负责人: RICHARD J FORD
• 金额: $ 25.41万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-01 至 2002-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6481855
• 关键词: biomedical facility; cancer registry /resource; cell bank /registry; cryopreservation; histopathology; human tissue; neoplasm /cancer classification /staging; tissue /organ preservation

The Tissue Procurement and Banking Facility (TPBF) is an established CCSG- supported core facility at the MDACC, that provides peer-funded basic science and clinical investigators at this institution with human tumor tissues that have been removed for biopsy or therapeutic resections, for on-going research projects. The TPBF functions to procure virtually all pathologic tumor tissue from patient procedures, that is not used for initial diagnosis, follow-up diagnostic studies, including cryogenically stored for future clinical follow-up. This tumor tissue is obtained to provide fresh, sterile (if requested), well-characterized human tumor specimens expeditiously (, 1 hour), to the wide spectrum of research scientists involved in virtually every type of human tumor investigation. Special preservation procedures will be instituted for nucleic acids and other methodologies for genomic analysis. The TPBF, that stores and triages tumor tissue for disease-site tumor programs, as well as cryopreservation, is being expanded into new, specifically designated and appropriate out-fitted space, to provide for more efficient and inclusive tumor banking facilities. The expanded banking facility will not only provide state-of-the-art cryopreservation facilities, but will also include an interactive database that will provide all pertinent information on tumor specimens procured by the TPBF. It will also interface with other institutional databases (hospital, pathology, epidemiology, etc.) that can provide vital and important data and other pertinent information to the searcher such as confidentiality/security. The specific aims of this proposal involve: 1) providing a flexible specialized tissue procurement resource providing for the efficient and expeditious delivery of freshly-obtained, well characterized tumor tissue to requesting investigators; 2) to develop a contemporary, centralized institution-wide tumor tissue procurement and banking core facility which will provide tissue compatible with current and predicted methodologies for analysis of DNA, RNA and protein as well as other methods of analysis; 3) to develop an interactive, accessible computer database which will provide epidemiology, family history, patient treatment and patient outcome and 4) to coordinate with existing individual "satellite", programmatically administered and funded tissue banks currently operational within the institution.

组织采购和银行设施（TPBF）是已建立的CCSG- MDACC的支持核心设施，该设施提供了同行资助的基本 该机构的科学和临床研究人员患有人类肿瘤 已去除活检或治疗切除的组织，用于 正在进行的研究项目。 TPBF功能几乎全部采购 患者手术的病理肿瘤组织，不用于 初始诊断，随访诊断研究，包括低温 存储用于将来的临床随访。该肿瘤组织被获得 提供新鲜的无菌（如果需要），特征良好的人类肿瘤 快速标本（1小时）到广泛的研究 几乎参与每种类型的人类肿瘤调查的科学家。 特殊保存程序将用于核酸和 基因组分析的其他方法。 TPBF，存储和 三叶叶肿瘤组织用于疾病部位的肿瘤程序，以及 冷冻保存，正在扩展为新的，专门指定的和 适当的外观空间，以提供更有效和更具包容性的 肿瘤银行设施。扩大的银行工厂不仅将 提供最先进的冷冻保存设施，但也将 包括一个可以提供所有相关的交互式数据库 有关TPBF购买的肿瘤标本的信息。它也会 与其他机构数据库（医院，病理学， 流行病学等）可以提供重要而重要的数据以及其他 与搜索者相关的信息，例如机密性/安全性。 该提案的具体目的涉及：1）提供灵活的 专门的组织采购资源为高效和 迅速递送新鲜的，表现良好的肿瘤组织 要求调查人员； 2）开发一个当代的，集中的 机构范围内的肿瘤组织采购和银行核心设施 将提供与当前和预测方法兼容的组织 用于分析DNA，RNA和蛋白质以及其他分析方法； 3）开发一个交互式，可访问的计算机数据库，该数据库将 提供流行病学，家族史，患者治疗和患者 结果和4）与现有的个人“卫星”协调， 目前通过编程管理和资助的组织库 机构内部运作。