Regional Center of Research Excellence in Cancer and Other Non-Communicable Disease Epidemiology and Prevention in Vietnam

越南癌症和其他非传染性疾病流行病学和预防卓越研究区域中心

• 批准号: 9355135
• 负责人: XIAO-Ou SHU
• 金额: $ 25.42万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-20 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9355135
• 关键词: Address; Adoption; Air Pollution; Asia; Bioinformatics; Cancer Center; Cancer Control; Cancer Etiology; Cancer Hospital; Cancer Research Project; Case-Control Studies; Centers for Disease Control and Prevention (U.S.); Centers of Research Excellence; Cessation of life; China; Cohort Studies; Collaborations; Collection; Colon; Communities; Community Surveys; Consultations; Consumption; Country; Developed Countries; Developing Countries; Diabetes Mellitus; Diet; Economic Development; Economics; Educational workshop; Effectiveness; Ensure; Epidemic; Epidemiology; Etiology; Florida; Foundations; Future; Goals; Government; Growth; Health; Hospitals; Incidence; Industrialization; Informatics; Institutes; Interdisciplinary Study; Investigation; Life Expectancy; Life Style; Liver; Lung; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Malignant neoplasm of liver; Malignant neoplasm of lung; Medical; Methodology; Municipalities; National Cancer Institute; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Oral cavity; Patients; Physical activity; Population; Population Study; Prevalence; Prevention; Prevention Research; Prevention program; Productivity; Protocols documentation; Public Health; Public Health Schools; Records; Rectum; Research; Research Design; Research Infrastructure; Research Methodology; Research Personnel; Research Support; Research Training; Resources; Risk; Risk Factors; Scholarship; Site Visit; Stomach; Surveys; Techniques; Time; Tobacco use; Training; Training Programs; Universities; Vietnam; Water Pollution; Woman; anticancer research; base; biobank; cancer care; cancer diagnosis; cancer prevention; cancer risk; cancer survival; disorder prevention; epidemiology study; experience; fighting; instrument; investigator training; leadership development; low and middle-income countries; malignant breast neoplasm; malignant stomach neoplasm; meetings; men; mortality; multidisciplinary; neoplasm registry; outcome forecast; population based; programs; research and development; success; symposium; treatment program; trend; virtual

Rapid economic growth, industrialization, and widespread adoption of a western lifestyle in Vietnam have been accompanied by an emerging epidemic of non-communicable diseases (NCDs). NCD research in Vietnam, however, is very limited and mainly restricted to NCD prevalence assessment and risk factor surveillance. Currently, there is no population-based epidemiological research program for cancer, diabetes, or other NCDs in Vietnam due to the lack of a population-based cancer registry, a dearth of well-trained investigators, and the absence of proper research support infrastructure. To address these challenges, we plan to establish a multi- institutional US-Vietnam-China partnership to plan and build a Regional Center of Research Excellence (RCRE) for NCD research in Vietnam. Our long-term goal is to establish a self-sustaining, high-impact NCD research and training center in Vietnam and to establish a large population-based cohort study for NCD research there. In this application, we propose to establish a formal partnership to be led by the Vanderbilt Epidemiology Center (VEC) and the Vanderbilt-Ingram Cancer Center, institutes with outstanding records of excellence in NCD research and capacity-building in LMICs, particularly in Asia, and the Vietnam National Institute for Cancer Control, the national leader in cancer care and control. Our regional partner, the Shanghai Municipal Center for Disease Control and Prevention (SCDC), will provide expertise in building NCD research and control programs that are most relevant to Vietnam. Our other partners in Vietnam, Hanoi Medical University and Hanoi School of Public Health, are leaders in Vietnam in NCD prevention research. Dr. Luu from the University of South Florida will bring to the RCRE his years of experience in coordinating health- related activities in Vietnam. We will conduct a consultative meeting to assess needs, capacity, and to set priorities that incorporate input from major medical universities, cancer registries, and government and non- governmental key stakeholders for NCD research. We will provide research capacity enhancement training via multiple site visits, an in-country workshop, a national NCD research conference, and scholarships to two Vietnamese investigators for more in-depth training at the SCDC and VEC. We will conduct a case-control study for breast cancer and a community survey for type 2 diabetes, two NCDs of particular public health concern in Vietnam, and collect biospecimens that will lay a foundation for future multi-disciplinary research. Through these activities, we will establish the Survey Research Support Core, the Biospecimen Processing and Biorepository Core, and the Bioinformatics and Informatics Core, the infrastructure essential to NCD epidemiology research, and develop an array of study instruments and protocols for future NCD studies in Vietnam. We will also develop plans to establish a longer-term research and training program for Vietnam that is also highly relevant for its neighboring LMIC countries. The long-standing collaborations among these partners and the strong institutional supports and commitments ensure success in implementing this RCRE.

越南经济的快速增长、工业化和西方生活方式的广泛采用 伴随着非传染性疾病（NCD）的流行。越南非传染性疾病研究， 然而，其作用非常有限，主要限于非传染性疾病患病率评估和危险因素监测。 目前，还没有针对癌症、糖尿病或其他非传染性疾病的基于人群的流行病学研究计划 在越南，由于缺乏基于人群的癌症登记、缺乏训练有素的调查人员以及 缺乏适当的研究支持基础设施。为了应对这些挑战，我们计划建立一个多 美国-越南-中国建立机构伙伴关系，规划和建立区域卓越研究中心 （RCRE）越南非传染性疾病研究。我们的长期目标是建立一个自我维持、高影响力的非传染性疾病 越南研究和培训中心，并针对非传染性疾病建立大规模人群队列研究 在那里进行研究。在此申请中，我们建议建立由范德比尔特大学领导的正式合作伙伴关系 流行病学中心 (VEC) 和范德比尔特-英格拉姆癌症中心，这些机构在 中低收入国家（特别是亚洲）的非传染性疾病研究和能力建设方面的卓越成就，以及越南国家 癌症控制研究所，癌症治疗和控制领域的国家领导者。我们的区域合作伙伴上海 市疾病预防控制中心 (SCDC) 将提供建设非传染性疾病研究方面的专业知识 以及与越南最相关的控制计划。我们在越南的其他合作伙伴河内医疗 大学和河内公共卫生学院是越南非传染性疾病预防研究的领导者。卢博士 来自南佛罗里达大学的博士将给 RCRE 带来他多年在协调健康方面的经验。 越南的相关活动。我们将召开协商会议来评估需求、能力并制定 优先事项纳入了主要医科大学、癌症登记处以及政府和非机构的投入 非传染性疾病研究的政府主要利益相关者。我们将通过以下方式提供研究能力增强培训 多次实地考察、一次国内研讨会、一次全国非传染性疾病研究会议，并为两人提供奖学金 越南调查人员在 SCDC 和 VEC 接受更深入的培训。我们将进行病例对照 乳腺癌研究和 2 型糖尿病社区调查，这是两种特殊公共卫生非传染性疾病 越南的关注，并收集生物样本，为未来的多学科研究奠定基础。 通过这些活动，我们将建立调查研究支持核心、生物样本处理 和生物储存库核心，以及生物信息学和信息学核心，这是非传染性疾病必不可少的基础设施 流行病学研究，并为未来非传染性疾病研究开发一系列研究仪器和方案 越南。我们还将制定计划，为越南建立长期研究和培训计划 与其邻近的中低收入国家也高度相关。这些机构之间的长期合作 合作伙伴以及强有力的机构支持和承诺确保了该 RCRE 的成功实施。

项目成果

The association between birth order and childhood brain tumors: a systematic review and meta-analysis.

出生顺序与儿童脑肿瘤之间的关联：系统评价和荟萃分析。

• 发表时间: 2019
• 作者: Nguyen, Mai V;Tran, Mo T;Tran, Chi TDu;Tran, Quang H;Tuonga, Thuy Tv;Phung, Lam N;Vu, Huyen X;Le, Linh C;Boffetta, Paolo;Luu, Hung N
• 通讯作者: Luu, Hung N

Racial/ethnic, age and sex disparities in leukemia survival among adults in the United States during 1973-2014 period.

1973-2014 年期间美国成年人白血病生存率的种族/民族、年龄和性别差异。

• 发表时间: 2019
• 影响因子: 3.7
• 作者: Utuama, Ovie;Mukhtar, Fahad;Pham, Yen Thi;Dabo, Bashir;Manani, Priyashi;Moser, Jenna;Michael;Tran, Chi Td;Le, Linh C;Le, Thanh V;Vu, Khanh Truong;Park, Jong Y;Boffetta, Paolo;Zheng, Wei;Shu, Xiao;Luu, Hung N
• 通讯作者: Luu, Hung N

Survival predictors of Burkitt's lymphoma in children, adults and elderly in the United States during 2000-2013.

2000-2013 年美国儿童、成人和老年人伯基特淋巴瘤的生存预测因子。

• 发表时间: 2017
• 影响因子: 6.4
• 作者: Mukhtar, Fahad;Boffetta, Paolo;Risch, Harvey A;Park, Jong Y;Bubu, Omonigho M;Womack, Lindsay;Tran, Thuan V;Zgibor, Janice C;Luu, Hung N
• 通讯作者: Luu, Hung N

Evaluations of Biomarker Status Changes between Primary and Recurrent Tumor Tissue Samples in Breast Cancer Patients.

乳腺癌患者原发性和复发性肿瘤组织样本之间生物标志物状态变化的评估。

• 发表时间: 2019
• 作者: Nguyen, Thi Hoa;Nguyen, Van Hung;Nguyen, Thanh Long;Qiuyin, Cai;Phung, Thi Huyen
• 通讯作者: Phung, Thi Huyen

Epidemiological Characteristics of Advanced Hepatocellular Carcinoma in the Northern Region of Vietnam.

越南北部地区晚期肝细胞癌的流行病学特征。

• 发表时间: 2019-01
• 作者: Le, Van Quang;Nguyen, Van Hieu;Nguyen, Van Hung;Nguyen, Thanh Long;Sudenga, Staci L;Trinh, Le Huy;Nguyen, Van Tung;Nguyen, Thi Thu Huong
• 通讯作者: Nguyen, Thi Thu Huong