Pediatric fMRI Technology Development

儿科功能磁共振成像技术开发

基本信息

批准号：
6775677
负责人：
Victor Andrew Stenger
金额：
$ 12.6万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-09-27 至 2006-09-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6775677
关键词：
adolescence (12-20)amygdala basal ganglia behavioral /social science research tag bioimaging /biomedical imaging brain mapping child (0-11)child behavior clinical research decision making functional magnetic resonance imaging human subject neural information processing neuroanatomy neuropsychology nucleus accumbens technology /technique development

项目摘要

DESCRIPTION (provided by applicant): Disturbances in the neural circuitry underlying reward processing and decision making are likely to be associated with an increased risk common emotional and addictive disorders that have their origins in childhood and adolescence. These disorders include depression and alcohol and nicotine abuse and dependence. It has now become possible to use fMRI to investigate this neural circuitry, together with its developmental trajectory and relationship with critical key physiological events such as puberty. However, these studies are severely hampered by critical methodological limitations, including the presence of magnetic susceptibility effects resulting in signal loss in many key brain regions (ventral striatum, amygdala, orbital frontal cortex), as well as issues related to the cross registration of sub-cortical and orbital frontal brain regions to facilitate the analysis of within and between group comparisons. In the present application, our multidisciplinary group of investigators will tackle these technical limitations and develop and validate solutions designed to improve our ability to investigate this brain circuitry and its development in healthy as well disordered groups of children and adolescents. We will optimize a rapid event-related Reward Contingent Decision (RCD) paradigm for acquisition of data in children and adolescents. We will also develop a whole-brain data acquisition method for rapid event-related pediatric fMRI at 3T that is robust to susceptibility artifacts by combining 3D tailored RF pulse excitations with SENSE acquisitions. Finally, we shall develop a novel volumetric image, deformable registration algorithm especially for deep sub-cortical gray matter structures such as the amygdala and the basal ganglia, including nucleus accumbens. The long term goals of this research are to take maximal advantage of the opportunity provided by event- related fMRI to achieve a better understanding of the development of neurobehavioral systems of reward that influence decision-making and risk appraisal in adolescence, achieve a more mechanistic understanding of the emergence of sensation seeking, risk-taking, and reckless behavior during adolescent development, and to use these methodological advances in fMRI to provide a more powerful cognitive neuroscientific framework for our ongoing developmental and clinical investigations into emotional and substance-use problems emerging during adolescence.

描述（由申请人提供）：奖励处理和决策制定的神经回路紊乱可能与起源于儿童和青春期的常见情绪和成瘾疾病的风险增加有关。这些疾病包括抑郁症以及酒精和尼古丁滥用和依赖。现在已经可以使用功能磁共振成像来研究这种神经回路，及其发育轨迹以及与青春期等关键生理事件的关系。然而，这些研究受到关键方法学限制的严重阻碍，包括磁化率效应的存在导致许多关键大脑区域（腹侧纹状体、杏仁核、眶额皮质）信号丢失，以及与亚子交叉配准相关的问题。 -皮质和眶额脑区域，以方便分析组内和组间比较。在本申请中，我们的多学科研究人员小组将解决这些技术限制，并开发和验证解决方案，旨在提高我们研究这种大脑回路及其在健康和紊乱的儿童和青少年群体中的发育的能力。我们将优化与事件相关的快速奖励偶然决策（RCD）范例，以获取儿童和青少年的数据。我们还将开发一种用于 3T 快速事件相关儿科 fMRI 的全脑数据采集方法，通过将 3D 定制 RF 脉冲激励与 SENSE 采集相结合，该方法对磁敏感伪影具有鲁棒性。最后，我们将开发一种新颖的体积图像可变形配准算法，特别适用于深层皮层下灰质结构，例如杏仁核和基底神经节，包括伏隔核。本研究的长期目标是最大限度地利用事件相关功能磁共振成像提供的机会，更好地了解影响青春期决策和风险评估的神经行为奖励系统的发展，获得更机械的理解青少年发展过程中寻求感觉、冒险和鲁莽行为的出现，并利用功能磁共振成像的这些方法论进步，为我们正在进行的情绪和物质使用的发展和临床研究提供更强大的认知神经科学框架青春期出现的问题。