Radial Echo Volumar Imaging

径向回波容积成像

• 批准号: 9980730
• 负责人: Victor Andrew Stenger
• 金额: $ 32.51万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-15 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9980730
• 关键词: 3-Dimensional; Acceleration; Algorithms; Benign; Brain; Brain imaging; Breathing; Computer software; Detection; Development; Diffusion; Dimensions; Echo-Planar Imaging; Frequencies; Functional Magnetic Resonance Imaging; Healthcare; Image; Magnetic Resonance Imaging; Maps; Methodology; Methods; Modeling; Modernization; Modification; Morphologic artifacts; Motion; Nature; Noise; Periodicity; Phase; Physiologic pulse; Physiological; Predisposition; Property; Protons; Radial; Research Personnel; Research Project Grants; Research Project Summaries; Research Proposals; Resolution; Rest; Rotation; Running; Sampling; Scanning; Scheme; Signal Transduction; Slice; Speed; Structure; Techniques; Technology; Time; Translations; base; blood oxygen level dependent; density; flexibility; image reconstruction; imaging approach; imaging modality; improved; innovation; interest; motion sensitivity; novel; perfusion imaging; reconstruction; resilience; success; temporal measurement

Project Summary This research project “Radial Echo Volumar Imaging” proposes the development of MRI acquisition and reconstruction methods based on a novel versatile non-Cartesian sampling concept for fast motion-corrected imaging. The technique expands upon Echo Planar Imaging (EPI), which is the most widely utilized fast MRI acquisition and is the standard method for various applications ranging from functional MRI to diffusion and perfusion imaging. Recently EPI has also been shown to be promising for rapid structural imaging including simultaneous multi-parametric MRI. Most modern EPI approaches are based on volumetric imaging methods as they permit high isotropic spatial resolution, improved Signal to Noise Ratio per unit time, and parallel imaging acceleration along the third dimension. A challenge of volumetric imaging however is the requirement for segmentation due to gradient and physiological limitations that leads to increased motion sensitivity and other physiological effects. Radial sampling offers several advantages with regards to segmented acquisitions including robustness to motion due to intrinsic self-navigation from oversampling the center of k-space. Radial sampling also has the benefit of producing benign “streaking” aliasing artifacts compared to Cartesian allowing for large accelerations and an efficient use of parallel imaging methods. A further advantage of radial sampling is that the in-plane dimension is sampled quickly by frequency encoding leading to higher in-plane resolution and less distortion with low time penalty. In this project we propose to utilize these advantages to develop innovative methodology for rapid and robust brain imaging that should also prove to be important for many other imaging applications including body MRI. The Scientific Premise of this proposal is that an optimal rapid MRI acquisition can be obtained by using three- dimensional radial EPI trajectories and generalized model-based reconstructions. We propose an innovative Radial Echo Volumar Imaging (REVI) acquisition created by adding gradient encoding along the third direction of a radial EPI acquisition to create SMS and 3D rotated “Stack-of-Stars” sampling for high parallel imaging acceleration while allowing for optimal tradeoffs in temporal and spatial resolutions. The self-navigation properties of the radial trajectories will provide motion robustness and continuous golden-angle rotation will permit variable temporal resolutions and reordering of the acquisition. The multi-echo nature of REVI will also allow for simultaneous multi-parametric structural scanning. The proposed technology requires no special hardware and can be run on any scanner by any investigator.

项目摘要 该研究项目“径向回声量成像”提出了MRI获取和 基于新型多功能非 - 牙犯抽样概念的重建方法，用于快速运动校正 成像。该技术扩展了回声平面成像（EPI），这是最广泛使用的快速MRI 获取，是各种应用的标准方法，从功能性MRI到扩散和 灌注成像。最近，EPI也已被证明是对快速结构成像的希望 同时进行多参数MRI。大多数现代EPI方法基于体积成像方法 因为它们允许高各向同性空间分辨率，每单位时间提高信号与噪声比，并平行 沿第三维的成像加速度。体积成像的挑战是要求 由于梯度和物理局限性导致的分割，导致运动灵敏度的提高和 其他身体效果。 径向采样在分段的收购中提供了几个优势，包括稳健性 由于过采样K空间中心而导致的动作引起的运动。径向采样也有 与笛卡尔相比，产生良性“条纹”别叠伪影的好处 并有效地使用并行成像方法。径向采样的另一个优点是平面内 通过编码频率来快速采样维度，导致平面内分辨率较高，失真较少 罚款低。在这个项目中，我们建议利用这些优势来开发创新的方法论 对于快速而健壮的大脑成像，这也应该证明对许多其他成像应用很重要 包括身体MRI。 该提案的科学前提是，可以通过使用三个 - 尺寸径向EPI轨迹和广义基于模型的重建。我们提出了创新的 径向回声体积成像（REDI）通过沿第三方向添加梯度编码创建的采集 用于创建SMS和3D旋转的“堆栈明星”采样的径向EPI采集以进行高平行成像 加速同时允许在临时和空间决议中进行最佳的权衡。自动训练 径向轨迹的特性将提供运动鲁棒性，并且连续的金角旋转将提供 允许可变的临时分辨率和对收购的重新排序。 Revi的多回波本质也将 允许简单的多参数结构扫描。提出的技术不需要特别 硬件，任何调查员都可以在任何扫描仪上运行。