New Point of Care System for Burn Wound Treatment

烧伤创面治疗的新护理点系统

• 批准号: 6585475
• 负责人: ADRIAN J DENVIR
• 金额: $ 11万
• 依托单位: LYNNTECH, INC.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-06-03 至 2004-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6585475
• 关键词: antiinfective agents; antisepsis; biotechnology; burn therapy; communicable disease control; disinfectants; electrochemistry; ozone; saline; technology /technique development; wound healing

DESCRIPTION (provided by applicant): Each year in the United States, two million people suffer burn injuries resulting in approximately 100,000 - 300,000 hospitalizations. Of these two million, more than 12,000 will eventually die of burn-related infections. People suffering from burn wounds have lost a portion of their integument, diminishing one of the body's main defenses against bacterial infection. In addition, the necrotic tissue in the burn eschar, combined with the presence of serum proteins, provides a rich culture medium for microorganisms. Added to the loss of integument is the adverse affect of thermal injury on both local and systemic immunity. For these reasons, infections and sepsis are the most common cause of death among hospitalized burn patient. New methods of burn wound management require a cocktail of antimicrobial and antibiotic agents to fight infection however; they are becoming less effective due to resistant strains of microorganisms. In this Phase I effort we will demonstrate the feasibility of a fundamentally new method for burn wound care. The point of care (POC) system will be designed to generate sterile saline or water to moisten or wet the dressings for both the eschar as well as the graft after excision and deliver a broad based antimicrobial agent effective, against gram positive and gram-negative bacteria and fungi to the wound surface.

描述（由申请人提供）：每年在美国，200万人遭受烧伤伤害，大约有100,000-300,000次住院。在这200万，超过12,000人中，最终将死于与烧伤有关的感染。患有烧伤的人失去了一部分外皮，减少了人体针对细菌感染的主要防御能力。另外，燃烧Eschar中的坏死组织与血清蛋白的存在相结合为微生物提供了丰富的培养基。外皮的丧失是热损伤对局部和全身免疫力的不利影响。由于这些原因，感染和败血症是住院的烧伤患者中最常见的死亡原因。烧伤伤口管理的新方法需要抗菌和抗生素剂的鸡尾酒来对抗感染。由于微生物的抗性菌株，它们的效果降低了。在这一阶段，我们将证明一种从根本上进行烧伤伤口护理方法的可行性。护理点（POC）系统将设计为产生无菌盐水或水，以润湿或润湿切除后的ESCHAR以及移植物，并提供有效的基于宽的抗菌剂，以抗Gram阳性和革兰氏阴性细菌和真菌。