Biofilm Prevention and Treatment Device

生物膜防治装置

• 批准号: 6691515
• 负责人: STEVEN R FRANK
• 金额: $ 10万
• 依托单位: ROSE BIOMEDICAL DEVELOPMENT CORPORATION
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-15 至 2004-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6691515
• 关键词: antisepsis; biofilm; biotechnology; catheterization; clinical biomedical equipment; communicable diseases; disease /disorder prevention /control; dosage; drug delivery systems; electronic pacemaker; implant; infection; iontophoresis therapy; microprocessor /microchip; prosthesis; silver; surface coating; technology /technique development

DESCRIPTION (provided by applicant): Biofilms account for over 80% of device related microbial infections in the body. They are highly resistant to antimicrobial agents and the body's immune system. They contaminate indwelling medical devices such as catheters and joint implants causing tens of thousands of deaths each year. Silver is a well-known antimicrobial. Anti-infective, passive silver coatings have been used on catheters and for burns. These passive coatings, however, cannot deliver a sustained dose to penetrate and kill multiple biofilms. This study proposes an active, iontophoretic, delivery system - Active Antisepsis (AA) - that electronically controls the dose and penetration of silver ions surrounding a treated medical device. This technology has been tested against S.aureus biofilm in a laboratory model. The AA not only killed the biofilm, it penetrated through the initial biofilm layer to kill a second layer of biofilm. In this study, AA will be tested on titanium, a common material used in various indwelling medical devices. Initial objectives include: Coating titanium test coupons with silver. Building a silver ion release controller based on previous prototypes. Testing the AA technology in comprehensive laboratory tests to assess the ability to kill multiple layers of infectious biofilms.

描述（由申请人提供）：生物膜占体内相关微生物感染的80％以上。它们对抗菌剂和人体的免疫系统具有高度抗性。它们每年污染诸如导管和关节植入物等居住的医疗设备，每年造成数以万计死亡。银是一种众所周知的抗菌剂。导管和烧伤已使用抗感染，被动银涂层。但是，这些被动涂料无法持续剂量以穿透和杀死多个生物膜。 这项研究提出了一种主动的，离子遗漏的，递送系统 - 主动反曲（AA） - 通过电子方式控制处理过的医疗装置周围的银离子的剂量和穿透。该技术已在实验室模型中针对S.Aureus生物膜进行了测试。 AA不仅杀死了生物膜，而且还穿过初始生物膜层以杀死第二层生物膜。 在这项研究中，AA将对钛进行测试，钛是一种用于各种留置医疗设备的常见材料。 最初的目标包括：带银的涂料钛测试优惠券。基于以前的原型构建银离子释放控制器。在综合实验室测试中测试AA技术，以评估杀死多层传染性生物膜的能力。