Single Step Surface Modification of NonFluorinated Polymers for Infection Control

用于感染控制的非氟化聚合物的一步表面改性

• 批准号: 7481574
• 负责人: ADRIAN J DENVIR
• 金额: $ 10.2万
• 依托单位: LYNNTECH, INC.
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2010-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7481574
• 关键词: Acquired Immunodeficiency Syndrome; Address; Adherence; Adverse effects; Anti-Infective Agents; Antibiotic Resistance; Antibiotics; Bacteria; Bacterial Adhesion; Candida albicans; Carbon; Catheter-related bloodstream infection; Catheters; Cause of Death; Cell Wall; Centers for Disease Control and Prevention (U.S.); Cessation of life; Characteristics; Charge; Chemicals; Complex; Contracts; Deformity; Devices; Electrostatics; Ensure; Enterococcus faecium; Environment; Equipment; Excision; Future; Gases; Generations; Goals; Growth; Healthcare; Heating; Human; Hydrogen Peroxide; Hydroxyl Radical; Infection; Infection Control; Intensive Care Units; Legal patent; Life; Mechanics; Medical; Medical Device; Medical Surveillance; Medicine; Methods; Microbe; Microbiology; Modification; Molds; Nosocomial Infections; Numbers; One-Step dentin bonding system; Organic Chemistry; Oxygen; Ozone; Patients; Peroxides; Phase; Plastics; Polymer Chemistry; Polymers; Population; Prevalence; Prevention strategy; Procedures; Process; Property; Pseudomonas aeruginosa; Public Health; Purpose; Rate; Reaction; Reactive Oxygen Species; Reporting; Reproduction spores; Research; Residual state; Resistance; Scientist; Sepsis; Shapes; Site; Skin; Staphylococcus aureus; Sterility; Surface; Techniques; Technology; Time; Tube; United States; Vacuum; Virus; antimicrobial; attributable mortality; base; commercialization; cost; day; fungus; implantable device; improved; interest; killings; malignant breast neoplasm; medical implant; microbial; microorganism; mortality; novel; oxidation; pathogen; perhydroxyl radical; pressure; prevent; seal; success; technical report; technology development; transmission process; vehicular accident

DESCRIPTION (provided by applicant): Catheter-related bloodstream infections (CR-BSI) occur at an average rate of 5 per 1,000 catheter days in intensive-care units in the United States, resulting in 80,000 episodes of CR-BSI per year. Most cases of CR- BSIs are caused by microorganisms that originate either from the skin of the patient and migrate along the external surface of the catheter (i.e., extraluminally), or from a contaminated catheter hub or tube and migrate along the internal surfaces (i.e., intraluminally). Therefore, successful prevention strategies must reduce colonization of the insertion site, hubs and tubing, minimize microbial spread extraluminally from the skin or intraluminally from the hubs and tubing, and/or inhibit adherence and growth of pathogens that reach the internal segment of the catheter. The ultimate objective is to develop a surface treatment that will simultaneously address all three of these strategies. The goal of this Phase I project is to introduce a unique processing method to demonstrate the feasibility of a single step antimicrobial surface modification that (1) can be applied to the surface of a variety of plastics, including polymers commonly used in catheters, hubs, and medical tubing; (2) can be formed on both the inner and outer surfaces of complex geometries; (3) will inhibit bacterial adhesion by nonspecific oxidative destruction and by electrostatic repulsion of negatively charged bacterial cell walls; (4) will be effective against bacteria, fungi, and spores; (5) and will not promote increased antibiotic resistance. PUBLIC HEALTH RELEVANCE: This technology provides a tremendous opportunity to improve the success rate of temporary and permanent medical implant devices that may otherwise cause life-threatening infection complications. Effective infection control technologies such as the one proposed will help alleviate the estimated $5.5 billion per year cost associated with the two million nosocomial infections acquired every year in the US.

描述（由申请人提供）：与导管相关的血液感染（CR-BSI）的平均速度为每1,000个导管天数，在美国的强化单位中，每年发生80,000次CR-BSI发作。大多数CRSI的病例是由微生物引起的，这些微生物源自患者的皮肤，并沿导管的外表面迁移（即外部外部），或者是从污染的导管枢纽或管子迁移的，并沿着内部表面迁移（即内部为内部）。因此，成功的预防策略必须减少插入部位，枢纽和管道的定殖，从皮肤外部从皮肤外延伸微生物散布，或者从集线器和管道内肿瘤，以及/或抑制病原体的粘附和生长，这些病原体的粘附和生长到达导管的内部段。最终目标是开发一种表面处理，该处理将同时解决这三种策略。该阶段项目的目的是引入一种独特的处理方法，以证明单步抗菌表面修饰的可行性，即（1）可以应用于多种塑料的表面，包括在导管，枢纽和医用管教中常用的聚合物； （2）可以在复杂几何形状的内部和外表面形成； （3）将通过非特异性氧化破坏和通过负电荷的细菌细胞壁抑制细菌粘附； （4）对细菌，真菌和孢子有效； （5）并且不会促进抗生素耐药性的增加。 公共卫生相关性：这项技术提供了一个巨大的机会，可以提高临时和永久性医疗植入设备的成功率，这些设备可能会导致威胁生命的感染并发症。有效的感染控制技术，例如提议的一种，将有助于减轻与每年在美国获得的200万个医生感染相关的估计每年55亿美元的费用。