High Field MRI: Limitations and Solutions

高场 MRI：局限性和解决方案

• 批准号: 6669175
• 负责人: MICHAEL B SMITH
• 金额: $ 175.66万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6669175
• 关键词: Aplysia; adult human (21+); bioengineering /biomedical engineering; bioimaging /biomedical imaging; body regions; clinical research; computer simulation; computer system design /evaluation; functional magnetic resonance imaging; head; human subject; image processing; laboratory rat; magnetic field; magnetic resonance imaging; method development; middle childhood (6-11); model design /development; neurons; patient oriented research; patient safety /medical error; radiowave radiation

DESCRIPTION (provided by applicant): The long-term objective of this research is to understand and develop engineering solutions to the difficulties presented to magnetic resonance imaging (MRI) at high magnetic field strength. Specific Aim 1: Develop and validate a methodology to analyze, quantify, and eliminate static field distortion artifacts produced in high field MR images by regional differences in magnetic susceptibility. This information will be used to develop artifact-correction techniques for high-speed functional MRI and distortion-free high field MRI of human, animal, and cellular anatomy. Specific Aim 1: Develop and validate models and methods to analyze and quantify radio frequency (RF) magnetic field distortions occurring in the human head and body of men, women, children, and fetuses in utero. These analyses will be used to evaluate regional RF power deposition from specific pulse sequences for patient safety and to develop methods to minimize RF inhomogeneity. In the spirit of the Bioengineering Research Partnership this proposal will draw expertise and partnership from the Center for Magnetic Resonance Research at the University of Minnesota (a premiere 7.0 Tesla whole body MRI research facility), REMCOM (a magnetic field modeling software company), and the National High Magnetic Field Laboratory (a National Research Laboratory incorporating 17.8 Tesla MRI microscopy and 11.7 Tesla small animal imaging). The results of these studies will aid a wide array of researchers in high speed distortion-free functional MRI, anatomical studies at both low and high field strengths, MR microscopy in animals and intact cells, evaluation of patient safety, and in many cases, reclaim techniques which have proven problematic at high field strengths.

描述（由申请人提供）：这项研究的长期目标是了解和开发高磁场强度下磁共振成像（MRI）的困难的工程解决方案。具体目标1：开发和验证一种方法来分析，量化和消除高场MR图像中通过磁敏感性的区域差异产生的静态场失真伪像。该信息将用于开发用于人类，动物和细胞解剖学的高速功能性MRI和无失真的高场MRI的人工校正技术。具体目标1：开发和验证模型和方法，以分析和量化射频（RF）磁场扭曲发生在子宫内男性，女人，儿童和胎儿的人体和身体中。这些分析将用于评估来自特定脉冲序列的区域RF功率沉积以确保患者的安全性，并开发方法以最大程度地减少RF不均匀性。本提案将在生物工程研究伙伴关系的精神上从明尼苏达大学（首映7.0 Tesla Tesla全身MRI研究设施），REMCOM（磁场模型公司）和国家高磁场实验室（国家高磁场实验室（国家高磁场实验室）（一家National High Mimbory Immoscoy）和17.8 TESLA MROSCOPY和17.8 TORE）。这些研究的结果将有助于无数的无失真功能性MRI，低田间强度和高田间强度的解剖学研究，动物和完整细胞中的MR显微镜，患者安全的评估以及在许多情况下，在高田间优势上证明有问题的技术。