Modeling Optimal Strategies to Prevent Cardiovascular Events in Older Adults

模拟预防老年人心血管事件的最佳策略

基本信息

批准号：
9015740
负责人：
Michelle Christina Odden
金额：
$ 13.75万
依托单位：
OREGON STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-02-01 至 2017-10-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9015740
关键词：
Adult Adverse effects Affect Age Aging American Antihypertensive Agents Benefits and Risks California Cardiovascular Diseases Cardiovascular system Cholesterol Clinical Clinical Sciences Cohort Studies Collaborations Comorbidity Computer Simulation Computers Data Decision Analysis Diabetes Mellitus Disease Dyslipidemias Elderly Epidemiologist Epidemiology Equilibrium Event Foundations Funding Future Gerontology Goals Health Health Professional Hypertension Incidence Individual Inflammation Institutes Intervention Investigation Knowledge Learning Life Literature Mentored Research Scientist Development Award Mentors Mentorship Methods Mission Modeling Morbidity - disease rate Myocardial Infarction NCI Scholars Program Obesity Older Population Outcome Pathway interactions Personal Satisfaction Persons Pharmaceutical Preparations Physical Function Physiological Policies Polypharmacy Population Prevalence Prevention Prevention strategy Preventive therapy Provider Public Health Public Health Practice Quality of life Quality-Adjusted Life Years Recommendation Renal function Research Research Personnel Research Support Research Training Risk Risk Factors San Francisco Science Stroke Training Translating Translational Research United States United States National Institutes of Health Universities age related aged base burden of illness cardiovascular disorder prevention cardiovascular disorder risk cardiovascular health career career development clinical practice evidence base functional status hypertension treatment improved markov model middle age mortality multidisciplinary novel prevent programs research to practice simulation skills

项目摘要

DESCRIPTION (provided by applicant): This Mentored Research Scientist Development Award application will provide an intensive research, training, and career development program for Dr. Michelle Odden, an epidemiologist and developing investigator at the University of California, San Francisco (UCSF). Her long-term career goal is to become a leader in the evidence-based prevention of cardiovascular disease (CVD) and related comorbid conditions in elderly adults. Older adults are living longer and healthier lives, yet much of the current literature on CVD epidemiology and prevention has been derived from younger populations. In this application, Dr. Odden will develop a comprehensive evidence base for prevention of CVD events in adults aged 75 years and older. Guided by her mentorship team, Dr. Odden will identify the strongest risk factors for CVD in the Cardiovascular Health Study, an ongoing NIH-funded cohort study of elderly adults. She will use the results of these analyses to inform computer simulations of CVD in older adults, in order to identify the most promising interventions for CVD prevention at the lowest risk for unintended side effects. Dr. Odden will conduct these simulations with the CHD Policy Model, an established computer model of CVD in the U.S. population. To achieve these goals, Dr. Odden and her mentors have developed the following specific aims:1) To describe the epidemiology of CVD events in adults 75 years and older, and to identify the strongest determinants of CVD events, among both traditional and age-related risk factors; 2) To forecast CVD incidence, prevalence, mortality, and quality of life in U.S. adults aged 75 years and older, by incorporating in-depth, novel epidemiological data into an established CVD computer model; 3) To estimate the potential impact of prevention strategies for CVD in U.S. adults aged 75 years and older on the extension of healthy life years, based on an established CVD computer model. The long term goal of this research is to prevent CVD events in adults over 75, and to extend the healthy years of life for older adults. This research supports the National Institutes of Health's mission to prevent disease and improve the health and well-being of Americans. The primary training goals of this application are to build a foundation of knowledge and skill set that will prepare Dr. Odden to be a successful independent researcher in translational research - from research to practice - in older adults. Through the training and the mentorship of a multidisciplinary team comprised of senior investigators at UCSF, and accomplished external advisors, she will learn the principles of gerontologic clinical science and cardiovascular prevention, and expand her methodological expertise to include forecasting and decision analysis methods. Additional training in implementation and dissemination science will enable her to translate her research findings into public health and clinical practice recommendations. She will participate in the Clinical and Translational K Scholars Program, offered by the UCSF Clinical and Translational Science Institute, which will offer crucial support and mentoring as she develops her research program in translational aging research.

描述（由申请人提供）：该指导研究科学家发展奖申请将为加州大学旧金山分校 (UCSF) 的流行病学家和发展研究员 Michelle Odden 博士提供深入的研究、培训和职业发展计划。她的长期职业目标是成为老年人心血管疾病 (CVD) 和相关合并症循证预防领域的领导者。老年人的寿命更长、更健康，但目前有关 CVD 流行病学和预防的大部分文献都来自年轻人。在此应用中，Odden 博士将开发一个全面的证据基础，用于预防 75 岁及以上成年人的 CVD 事件。在她的导师团队的指导下，奥登博士将在心血管健康研究中确定心血管疾病的最强危险因素，这是一项由美国国立卫生研究院资助的正在进行的老年人队列研究。她将利用这些分析结果为老年人 CVD 的计算机模拟提供信息，以便确定最有希望的 CVD 预防干预措施，同时将意外副作用的风险降至最低。奥登博士将使用 CHD 政策模型（美国人口中已建立的 CVD 计算机模型）进行这些模拟。为了实现这些目标，Odden 博士和她的导师制定了以下具体目标：1) 描述 75 岁及以上成年人中 CVD 事件的流行病学，并确定传统人群和年龄人群中 CVD 事件的最强决定因素。相关风险因素； 2) 通过将深入、新颖的流行病学数据纳入已建立的 CVD 计算机模型，预测 75 岁及以上美国成年人的 CVD 发病率、患病率、死亡率和生活质量； 3) 根据已建立的 CVD 计算机模型，估计 75 岁及以上美国成年人的 CVD 预防策略对延长健康寿命的潜在影响。这项研究的长期目标是预防 75 岁以上成年人的 CVD 事件，并延长老年人的健康寿命。这项研究支持美国国立卫生研究院预防疾病和改善美国人的健康和福祉的使命。该应用程序的主要培训目标是建立知识和技能基础，使奥登博士成为一名成功的老年人转化研究（从研究到实践）的独立研究员。通过由加州大学旧金山分校高级研究人员和资深外部顾问组成的多学科团队的培训和指导，她将学习老年学临床科学和心血管预防的原理，并扩展她的方法学专业知识，包括预测和决策分析方法。实施和传播科学方面的额外培训将使她能够将她的研究成果转化为公共卫生和临床实践建议。她将参加加州大学旧金山分校临床和转化科学研究所提供的临床和转化 K 学者项目，该项目将为她开发转化衰老研究的研究项目提供重要的支持和指导。