FMRI ANALYSIS OF IMPLICIT MEMORY IN NORMAL AGING

正常衰老过程中内隐记忆的 FMRI 分析

• 批准号: 6629848
• 负责人: DEBRA A FLEISCHMAN
• 金额: $ 44.13万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-05-15 至 2005-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6629848
• 关键词: Alzheimer's disease; age difference; aging; behavior test; bioimaging /biomedical imaging; brain imaging /visualization /scanning; clinical research; cognition; frontal lobe /cortex; functional magnetic resonance imaging; human old age (65+); human subject; learning; memory; neural information processing; neuropsychological tests; neuropsychology; semantics; short term memory; visual stimulus; young adult human (21-34)

The goal of this proposal is to test a novel theory about the psychological and neural bases of age-related decline in repetition priming, a form of implicit memory. Recent reviews note a host of apparently contradictory findings concerning whether all or some forms of priming are preserved in normal aging. Traditional neuropsychological frameworks, such as the explicit/implicit or the perceptual/conceptual distinctions, appear unable to clarify these contradictions. Many of these findings may be accommodated by a theory that proposes that (1) the frontal-lobes make critical contributions to production, but not identification, forms of priming, and (2) frontal-lobe dysfunction is variable in normal aging. Normal old and Alzheimer's disease (AD) participants will be sampled from a single population and optimally and identically characterized along neurological and neuropsychological dimensions. They will be compared to a sample of young participants in a series of behavioral and functional magnetic resonance imaging (fMRI) studies that test the following specific hypotheses: 1) production forms of priming are reduced in old participants without clinical AD and further reduced in old participants with clinical AD, whereas identification forms of priming are not reduced in old participants with or without AD; 2) in old participants without clinical AD, production forms of priming are related to performance on cognitive tests that are known to be mediated by the frontal-lobes; 3) in young participants, production forms of priming make greater demands on frontal-lobe regions, measured by fMRI, than do identification forms of priming; and 4) in old participants without clinical AD, production forms of priming are related to fMRI measures of frontal-lobe function.

该提议的目的是测试有关 与年龄相关的重复启动下降的心理和神经基础，一个 隐式内存的形式。最近的评论指出了许多显然矛盾的 有关所有形式的启动或某种形式的启动的发现 正常衰老。传统的神经心理学框架，例如 显式/隐式或感知/概念区别，似乎无法 澄清这些矛盾。这些发现中的许多可能由 提出（1）额叶对（1）对 生产但没有识别，启动形式，（2）额叶 正常衰老的功能障碍是可变的。正常老年和阿尔茨海默氏病 （AD）参与者将从一个人群中进行采样，并最佳地进行 沿神经系统和神经心理学维度相同。 他们将与一系列年轻参与者的样本进行比较 测试的行为和功能磁共振成像（fMRI）研究 以下特定假设：1）减少启动的生产形式 在没有临床广告的旧参与者中，旧参与者进一步减少 使用临床广告，而启动的识别形式并未减少 有或没有广告的老参与者； 2）在没有临床的老参与者中 AD，启动的生产形式与认知测试的性能有关 已知是由额叶围绕的介导的； 3）在年轻参与者中， 启动的生产形式对额叶区域提出了更大的需求， 通过fMRI衡量，比启动的识别形式。和4）老 没有临床广告的参与者，启动的生产形式与 FMRI额叶函数的度量。