FMRI ANALYSIS OF IMPLICIT MEMORY IN NORMAL AGING

正常衰老过程中内隐记忆的 FMRI 分析

• 批准号: 6745163
• 负责人: DEBRA A FLEISCHMAN
• 金额: $ 39.04万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-05-15 至 2006-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6745163
• 关键词: Alzheimer' s disease; age difference; aging; behavior test; bioimaging /biomedical imaging; brain imaging /visualization /scanning; clinical research; cognition; frontal lobe /cortex; functional magnetic resonance imaging; human old age (65+); human subject; learning; memory; neural information processing; neuropsychological tests; neuropsychology; semantics; short term memory; visual stimulus; young adult human (21-34)

The goal of this proposal is to test a novel theory about the psychological and neural bases of age-related decline in repetition priming, a form of implicit memory. Recent reviews note a host of apparently contradictory findings concerning whether all or some forms of priming are preserved in normal aging. Traditional neuropsychological frameworks, such as the explicit/implicit or the perceptual/conceptual distinctions, appear unable to clarify these contradictions. Many of these findings may be accommodated by a theory that proposes that (1) the frontal-lobes make critical contributions to production, but not identification, forms of priming, and (2) frontal-lobe dysfunction is variable in normal aging. Normal old and Alzheimer's disease (AD) participants will be sampled from a single population and optimally and identically characterized along neurological and neuropsychological dimensions. They will be compared to a sample of young participants in a series of behavioral and functional magnetic resonance imaging (fMRI) studies that test the following specific hypotheses: 1) production forms of priming are reduced in old participants without clinical AD and further reduced in old participants with clinical AD, whereas identification forms of priming are not reduced in old participants with or without AD; 2) in old participants without clinical AD, production forms of priming are related to performance on cognitive tests that are known to be mediated by the frontal-lobes; 3) in young participants, production forms of priming make greater demands on frontal-lobe regions, measured by fMRI, than do identification forms of priming; and 4) in old participants without clinical AD, production forms of priming are related to fMRI measures of frontal-lobe function.

该提案的目标是测试一种关于 与年龄相关的重复启动下降的心理和神经基础， 内隐记忆的形式。最近的评论指出了许多明显矛盾的内容 关于是否所有或某些形式的启动都保留在 正常老化。传统的神经心理学框架，例如 显式/隐式或感知/概念的区别，似乎无法 澄清这些矛盾。其中许多发现可能会被一个 该理论提出 (1) 额叶对 产生，但不是识别，启动形式，以及（2）额叶 正常衰老过程中功能障碍是可变的。正常老年人和阿尔茨海默病 (AD) 参与者将从单一人群中抽样，并以最佳方式进行 在神经学和神经心理学维度上具有相同的特征。 他们将与一系列的年轻参与者样本进行比较 行为和功能磁共振成像 (fMRI) 研究测试 具体假设如下：1）启动的产生形式减少 在没有临床 AD 的老年参与者中，在老年参与者中进一步减少 与临床 AD 一样，而启动的识别形式在 有或没有 AD 的老参与者； 2) 没有临床经验的老年参与者 AD，启动的产生形式与认知测试的表现有关 已知是由额叶介导的； 3）在年轻参与者中， 启动的产生形式对额叶区域提出了更高的要求， 通过功能磁共振成像（fMRI）测量，而不是识别启动形式； 4）旧的 没有临床 AD 的参与者，启动的产生形式与 额叶功能的功能磁共振成像测量。

项目成果

Age-associated reduction of asymmetry in prefrontal function and preservation of conceptual repetition priming.

• DOI: 10.1016/j.neuroimage.2008.10.019
• 发表时间: 2009-03-01
• 期刊: NeuroImage
• 影响因子: 5.7
• 作者: Bergerbest D;Gabrieli JD;Whitfield-Gabrieli S;Kim H;Stebbins GT;Bennett DA;Fleischman DA
• 通讯作者: Fleischman DA