AGING AND IMPLICIT MEMORY--EVIDENCE FROM LESION STUDIES

衰老与内隐记忆——来自损伤研究的证据

• 批准号: 2054898
• 负责人: DEBRA A FLEISCHMAN
• 金额: $ 10.31万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-05-01 至 2000-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2054898
• 关键词: Alzheimer's disease; aging; brain disorders; brain injury; cognition; diencephalon; frontal lobe /cortex; human old age (65+); human subject; longitudinal human study; magnetic resonance imaging; memory; memory disorders; neural information processing; neuropsychology; occipital lobe /cortex; parietal lobe /cortex; pathologic process; semantics; temporal lobe /cortex; visual perception

A five-year program of research is proposed that aims to (1) further characterize the functional neural architecture of implicit memory for words and objects by linking specific implicit memory processes to specific neural systems through studies of patients with focal neurological damage, and (2) examine how processing in these systems changes as a function of time and progressive multi-focal disease through studies of normal aged and patients with Alzheimer's disease (AD). Recent findings with focal lesion and AD patients indicate that there may be separable neural systems that mediate three forms of implicit memory and that there may be two visual implicit memory systems. In Study 1a, repetition priming tests, thought to selectively invoke processing in these implicit memory systems, will be administered to patients with single brain lesions in circumscribed regions of either the occipital, temporal, parietal, or frontal neocortex. In patients who exhibit informative dissociations, an MRI protocol will be used that, through three-dimensional reconstruction and rendering analyses, will permit specification of the lesions in terms of gyral anatomy and Brodmann areas. In Study 1b, patients with focal occipital lobe lesions will be used to test the hypotheses that the right occipital lobe mediates and apperceptive kind of visual implicit memory that retains form-specific information about words and pictures and the left occipital lobe mediates an associative kind of visual implicit memory that retains categorical information about words and pictures. In Study 2, a longitudinal study of implicit memory in AD will be conducted. For this study, groups of AD patients and normal aged subjects will be selected from a single, well- characterized cohort to test the broad hypothesis that the implicit processing that occurs in dissociable memory systems will have differential rates of change across of the course of AD.

提出了为期五年的研究计划，旨在进一步 表征隐式记忆的功能性神经结构 通过将特定隐式内存过程链接到单词和对象 特定神经系统通过对局灶性患者的研究 神经损害，以及（2）检查这些系统中的处理方式 随着时间的变化和进行性多焦局部疾病的变化 对正常年龄和阿尔茨海默氏病（AD）患者的研究。最近的 患有局灶性病变和AD患者的发现表明 可分离的神经系统，介导三种形式的隐式记忆和 可能有两个视觉隐式内存系统。在研究1a中， 重复启动测试，被认为是选择性调用处理的 这些隐式存储系统将用于患有 枕骨的限制区域中的单脑病变， 颞，顶或额叶新皮层。在表现的患者中 信息的分离，将使用MRI协议，通过 三维重建和渲染分析将允许 在回旋解剖和布罗德曼方面的病变规格 区域。在研究1B中，局灶性枕叶病变的患者将是 用于检验右枕叶介导的假设和 具有特定表格特定形式的视觉隐式记忆类型 有关单词和图片以及左枕叶中介的信息 一种保留分类的视觉隐式记忆 有关单词和图片的信息。在研究2中，一项纵向研究 将进行AD中隐式记忆。对于这项研究，广告组 患者和正常老年受试者将从单个，良好的人中选择 表征同类的，以检验隐式的广泛假设 在可分离的内存系统中发生的处理将具有 广告过程中的变化差异差异。