Conference on Muscle: Excitation-Contraction Coupling

肌肉会议：兴奋-收缩耦合

• 批准号: 6598909
• 负责人: MARTIN F SCHNEIDER
• 金额: $ 1.7万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-05-01 至 2004-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6598909
• 关键词: meeting /conference /symposium; muscle contraction; striated muscles; travel

DESCRIPTION (provided by applicant): This is a proposal for partial funding of a Gordon Research Conference on Muscle: Excitation-Contraction (E-C) Coupling to be held in June 2003. E-C coupling is the process that translates a muscle action potential into an increase in [Ca2+]i and contraction. Recent advances have brought into sharp focus the necessity of understanding the molecular events that underlie E-C coupling, in particular, the interaction between the two intramembrane molecules that are key to E-C coupling, the sarcoplasmic reticulum Ca2+ release channel or ryanodine receptor (RyR) and the transverse tubule voltage sensor or dihydropyridine receptor (DHPR). The meeting will bring together specialists in membrane protein structure, human genetics, molecular biology, biochemistry, biophysics and physiology to discuss the approaches that will advance molecular understanding of Ca2+ signaling in skeletal muscle, with implications for other tissues. The problems considered by this diverse group will range from molecular structure through the physiological results of molecular manipulation and modification of the key proteins underlying muscle activation. The meeting will focus discussion on several key aspects of Ca2+ signaling in skeletal muscle in nine platform sessions: (1) cellular organization and molecular structures of key proteins; (2) molecular interactions between DHPR and RyR; (3) molecular basis and pathophysiology of inherited muscle diseases caused by defects in E-C coupling proteins; (4) elementary events of Ca2+ release; (5) accessory protein and biochemical modulation of RyR function; (6) molecular manipulation and expression of E-C coupling components; (7) global calcium transients and fatigue in muscle fibers; (8) excitation transcription coupling in muscle and other cells; (9) other Ca2+ pathways in muscle. Posters will be shown continuously. The Gordon Conference on Muscle: E-C coupling, held every three years for several decades, has consistently been the sole forum in which active investigators from all over the world are brought together for discussion and dissemination of ideas that have led to advances in this field. The format encourages free exchange of ideas and unpublished data. The organizing committee and session leaders will strive to achieve appropriate representation of women, minorities and disabled. All facilities are handicapped accessible.

描述（由申请人提供）： 这是戈登肌肉研究会议部分资金的一项提议：2003年6月举行的肌肉研究会议：激发反应（E-C）耦合。E-C耦合是将肌肉动作潜力转化为[CA2+] I和收缩的增加的过程。最近的进步已引起人们的重点，需要理解E-C耦合的分子事件，尤其是膜内分子之间的相互作用，这些分子是E-C耦合的关键，这是E-C耦合的关键，Sarcoplasmic网状Ca2+释放通道或ryanodine受体（Ryr）受体（RYR）和横向小管受体或横向小管的传感器或DIH dih thyy（ry）。这次会议将汇集膜蛋白结构，人遗传学，分子生物学，生物化学，生物物理学和生理学的专家，以讨论将提高骨骼肌中Ca2+信号传导的分子理解的方法，对其他组织的影响。这个多样性组考虑的问题范围从分子结构到分子操作的生理结果和修饰肌肉激活的关键蛋白。 会议将重点讨论在九个平台会话中骨骼肌中Ca2+信号传导的几个关键方面：（1）关键蛋白的细胞组织和分子结构； （2）DHPR和RYR之间的分子相互作用； （3）由E-C偶联蛋白缺陷引起的遗传性肌肉疾病的分子基础和病理生理学； （4）Ca2+释放的基本事件； （5）RYR功能的辅助蛋白和生化调制； （6）E-C耦合成分的分子操纵和表达； （7）肌肉纤维中的全球钙瞬变和疲劳； （8）肌肉和其他细胞中的激发转录耦合； （9）肌肉中的其他CA2+途径。海报将连续显示。 Gordon肌肉：E-C耦合会议每三年举行了几十年，一直是唯一的论坛，在该论坛上，来自世界各地的活跃调查人员聚集在一起进行讨论和传播，这些思想导致了这一领域的进步。该格式鼓励自由交换思想和未发表的数据。组织委员会和会议领导人将努力实现妇女，少数民族和残疾人的适当代表。所有设施均可访问。