GORDON RES CONF: MUSCLE EXCITATION-CONTRACTION COUPLING

GORDON RES CONF：肌肉兴奋-收缩耦合

• 批准号: 6130418
• 负责人: DAVID H MACLENNAN
• 金额: $ 1.8万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-05-01 至 2001-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6130418
• 关键词: action potentials; calcium channel; meeting /conference /symposium; membrane channels; muscle contraction; myocardium; striated muscles; travel

DESCRIPTION (Taken from the applicants abstract): This is a proposal for partial funding of a Gordon Research Conference on Muscle: Excitation-Contraction (E-C) Coupling to be held in June, 2000. E-C coupling is the process that translates a muscle action potential into an increase in [Ca2+]i and contraction. Recent advances have brought into sharp focus the necessity of understanding the molecular events that underlie E-C coupling. In particular, the interaction between the two sarcotubular molecules that are key to E-C coupling. The Ca release channel ryanodine receptor (RyR) and the voltage sensor or dihydropyridine receptor (DHPR). The meeting will bring together specialists in membrane protein structure, human genetics, molecular biology, biochemistry, biophysics and physiology to discuss the approaches that will advance molecular understanding of Ca signaling in skeletal and cardiac muscle, with implications for other tissues. The problems dicussed by this diverse group will become more sharply defined as high resolution structures of the molecules under study become available. The meeting will focus discussion on several key Ca signaling molecules in skeletal and cardiac muscle in nine platform sessions: session 1, molecular structures of key proteins; session 2, molecular basis and pathophysiology of inherited muscle diseases caused by defects in E-C coupling proteins; session 3, structure-function relationships in RyR; session 4, interactions between RyR and DHPR; sessions 5 and 6, modulation of RyR activity by other proteins and transmembrane gradients and pharmacological agents: session 7, determination of elementary events of Ca release; session 8, global aspects of Ca release; and session 9, diversity among Ca release channels and novel proteins. Posters will be shown continuously. The Gordon Conference on Muscle: E-C coupling, held every three years for several decades, has consistently been the sole forum in which active investigators from all over the world are brought together for discussion and dissemination of ideas that have led to advances in this field. The format encourages the exchange of ideas and unpublished data. The organizing committee, with representatives of varying ages from five continents, will strive to achieve appropriate representation of women. minorities and disabled.

描述（取自申请人摘要）：这是一个建议 戈登肌肉研究会议的部分资金： 激发诱导（E-C）耦合将于2000年6月举行。 将肌肉动作潜力转化为增加的过程 [Ca2+] I和收缩。最近的进步已引起了人们的重点 理解E-C耦合构成的分子事件的必要性。在 特别是，两个是关键的两个肌管分子之间的相互作用 到E-C耦合。 CA释放通道Ryanodine受体（RYR）和 电压传感器或二氢吡啶受体（DHPR）。 会议将汇集膜蛋白结构的专家， 人类遗传学，分子生物学，生物化学，生物物理学和生理学 讨论将提高分子理解CA的方法 骨骼和心肌的信号传导，对其他组织产生影响。 这个多元化群体引起的问题将变得更加明确地定义为 研究分子的高分辨率结构可用。这 会议将重点讨论骨骼中的几个关键CA信号分子 九个平台会议中的心肌和心脏肌肉：会议1，分子结构 关键蛋白；第2节，遗传的分子基础和病理生理学 由E-C偶联蛋白缺陷引起的肌肉疾病；会议3， RYR中的结构功能关系；第4节，RYR之间的互动 和DHPR;会议5和6，其他蛋白质对RYR活性的调节， 跨膜梯度和药理学剂：第7节，确定 CA释放的基本事件；第8节，CA版本的全球方面；和 第9节，CA释放通道和新型蛋白质之间的多样性。海报会 连续显示。 Gordon肌肉大会：E-C耦合，举行 几十年来每三年每三年一直是唯一的论坛 来自世界各地的哪些活跃的调查员聚集在一起 讨论和传播导致该领域进步的思想。 该格式鼓励交换思想和未发表的数据。这 组织委员会，有五个年龄的代表 大洲将努力实现适当的妇女代表。 少数民族和残疾人。