Silvio O. Conte Center for Oxytocin and Social Cognition

西尔维奥·孔特催产素和社会认知中心

基本信息

批准号：
9250208
负责人：
Larry J Young
金额：
$ 181.64万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-07-01 至 2018-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9250208
关键词：
Affect Amygdaloid structure Animals Area Attention Autoradiography Brain Brain region Clinical Clinical Ethics Clinical Sciences Clinical Trials Communities Complex Consultations Cues Data Data Analyses Development Education Education and Outreach Electrophysiology (science)Emotions Environment Ethics Eye Face Faculty Functional Magnetic Resonance Imaging Future Goals Health Services Research Histology Human Human Resources Individual Institutes Interdisciplinary Study Intranasal Administration Learning Ligands Macaca mulatta Mediating Mental Health Mental disorders Nature Neurons Neurosciences Oxytocin Oxytocin Receptor Participant Peripheral Pharmacology Phenotype Positron-Emission Tomography Primates Productivity Rattus Research Research Design Research Infrastructure Research Personnel Research Project Grants Research Support Research Training Rewards Rodent Schools Scientist Series Services Social Behavior Social Functioning Social Interaction Social Perception Social Values Stimulus System Techniques Testing Therapeutic Time Training Training Activity Training Programs Translational Research Underrepresented Minority autism spectrum disorder base cognitive testing comparative drug development experience forging high school human subject improved in vivo information processing interdisciplinary approach lectures meetings neurochemistry neuromechanism novel novel strategies outreach prairie vole programs public education public health relevance receptor expression relating to nervous system response social social attachment social cognition tool training opportunity undergraduate research web site

项目摘要

DESCRIPTION (provided by applicant): The oxytocin (OT) system is arguably the most viable target for pharmacologically enhancing social cognition in psychiatric disorders with compromised social cognition, including autism spectrum disorder (ASD). Central OT enhances key aspects of social behavior in animals, and intranasal (IN) OT modulates social cognition in humans. The mechanisms by which OT affects social cognition are not understood. We will launch a coordinated, interdisciplinary research program involving an outstanding team of investigators to test the hypothesis that OT enhances social cognition by increasing the salience and reinforcing value of social stimuli by modulating activity and functional connectivity of the amygdala and brain regions involved in reward. Project scientists will use cutting edge techniques to assess functional connectivity between brain regions during social interactions, responses of individual neurons in the amygdala to social stimuli, or social cognition in animals and humans. Projects 1 and 2 will use in vivo electrophysiology to examine the impact of OT on the neural representation of social stimuli in rodents and rhesus macaques. Project 3 will use cognitive tests to examine the impact of OT on social perception and social attunement in the primate. Project 4 will use cognitive testing and fMRI to examine the impact of OT on social cognition and neural activity in healthy and autistic humans. A Neurochemistry Core will provide vital services for the research projects and develop new tools for characterizing OT receptor expression in the brain. An Administrative Core will coordinate all Center related activities (seminar series, organizing meetings), will provide statistical consultation and coordinate outreach and training activities of Center personnel by strengthening existing relationships and forging new relationships with numerous organizations in the Atlanta area. As a result, the Center will create vibrant collaborative research, training and outreach environment that will have a national impact on mental health research. The data collected by Center faculty will have important translational implications that will directly impact novel strategies for pharmacologically treating social deficits in psychiatric disorders.

描述（由申请人提供）：对于社会认知受损的精神疾病，包括自闭症谱系障碍（ASD），催产素（OT）系统可以说是从药理学上增强社会认知的最可行的靶标。中枢 OT 增强动物社会行为的关键方面，鼻内 (IN) OT 调节人类的社会认知。 OT 影响社会认知的机制尚不清楚。我们将启动一个协调的、跨学科的研究计划，由一支优秀的研究人员团队参与，以检验这样的假设：OT 通过调节杏仁核和参与奖励的大脑区域的活动和功能连接来增加社会刺激的显着性和强化价值，从而增强社会认知。项目科学家将使用尖端技术来评估社会互动过程中大脑区域之间的功能连接、杏仁核中单个神经元对社会刺激的反应或动物和人类的社会认知。项目 1 和 2 将利用体内电生理学来研究 OT 对啮齿动物和恒河猴社交刺激的神经表征的影响。项目 3 将使用认知测试来检查 OT 对灵长类动物的社会感知和社会协调的影响。项目 4 将使用认知测试和功能磁共振成像来检查 OT 对健康和自闭症人类的社会认知和神经活动的影响。神经化学核心将为研究项目提供重要服务，并开发用于表征大脑中 OT 受体表达的新工具。行政核心将协调所有与中心相关的活动（系列研讨会、组织会议），通过加强与亚特兰大地区众多组织的现有关系和建立新关系，提供统计咨询并协调中心人员的外展和培训活动。因此，该中心将创造充满活力的合作研究、培训和推广环境，这将对心理健康研究产生全国性的影响。中心教师收集的数据将具有重要的转化意义，将直接影响药物治疗精神疾病社会缺陷的新策略。