FLYBASE--A DROSOPHILA GENOMIC AND GENETIC DATABASE

Flybase——果蝇基因组和遗传数据库

基本信息

批准号：
6660557
负责人：
WILLIAM MARTIN GELBART
金额：
$ 8.85万
依托单位：
HARVARD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1992
资助国家：
美国
起止时间：
1992-08-01 至 2003-11-30
项目状态：
已结题

项目摘要

The fruit fly, Drosophila, is one of the most important model organisms for many aspects of modern biological research, especially for issues regarding the biology of metazoa. Comparative studies have clearly demonstrated that the metabolic, cellular, and developmental regulatory networks are highly conserved within the animal kingdom, and in many cases, even to other taxa. Particularly because of the sophisticated genetics of the fruit fly, Drosophila melanogaster, the best-studied drosophilid species, it has led the way in elucidating many of the pathways. Much work in mammalian systems, especially the mouse and humans, has been completely based on the strong foundation that Drosophila research has provided. We are now at the point were we are beginning to understand the physiological roles of many of the roles that, when mutated, contribute to human disease. In many cases, the insights emerge largely from work on the Drosophila cognates of these genes. To take maximum advantage of the information of the information available for Drosophila, both for the Drosophila, both for the Drosophila researcher and for scientists working on other organisms, it is essential that data on the fly be organized and accessible to the broad biological community. This is the role of the Flybase Consortium. In this application, FlyBase requests 5 years of funding to continue its effort to provide the scientific community with the essential genomic and genetic information on D. melanogaster, and other drosolipids. This information will continue to be readily accessible on-line through the Flybase WWW server, mirrored at several sites throughout the world. An important new aspect of the project is the merger of the public informatics teams of the Berkeley and European Drosophila Genome Projects with the original FlyBase group to become an expanded FlyBase Consortium. This new FlyBase Consortium will provide the community with a completely unified view of all Drosophila genetic and genomic data from the whole organism and population structure information down to the sequence level. The expanded project will involve close coordination among the 5 participating sites of data capture, management, organization and presentation. Important features for the research community will be a re-organization of the WWW server and a implementation of a variety of new tools, including many Java-based graphical displays. One issue for the biological databases to address is how to interconnect effectively among themselves. Issue of interconnectivity are crucial, as only a fraction of the relevant biology can be housed in a single repository. FlyBase will continue in its historic leadership role in promoting interconnections: through working with other groups to produce software that will permit data exchange between databases, and generally through contributing to a joint effort to address the needs of the scientific community.

果蝇果蝇是最重要的模型生物之一对于现代生物学研究的许多方面，尤其是针对问题关于后生动物的生物学。比较研究显然证明了代谢，细胞和发育调节网络在动物王国内是高度保守的，在许多人中案例，甚至是其他分类单元。特别是因为复杂的果蝇的遗传学，果蝇Melanogaster，最研究的果蝇物种，它领先于阐明许多途径。在哺乳动物系统中，尤其是老鼠和人类中的许多工作完全基于果蝇的强大基础研究提供了。我们现在正在开始了解许多角色的生理角色突变，有助于人类疾病。在许多情况下，见解出现主要是从这些基因的果蝇同源的工作。服用可用信息的信息的最大优势果蝇的果蝇，都是果蝇研究人员对于从事其他生物的科学家来说，数据至关重要在宽阔的生物群落中可以组织并可以使用。这是Flybase联盟的作用。在此应用中，flybase 要求提供5年的资金，以继续努力提供具有基本基因组和遗传信息的科学界 D. Melanogaster和其他drosolipids。这些信息将继续可以轻松地通过Flybase www服务器在线访问，在全世界的几个站点。一个重要的新方面项目是伯克利公共信息团队的合并欧洲果蝇基因组与原始的飞箱组计划成为一个扩大的飞箱财团。这个新的飞箱财团将为社区提供所有果蝇的完全统一的看法来自整个生物体和种群结构的遗传和基因组数据信息降至序列水平。扩展的项目将涉及在5个参与数据捕获的站点之间密切的协调，管理，组织和演示。重要功能研究社区将是www服务器的重组和实施各种新工具，包括许多基于Java 图形显示。生物数据库要解决的一个问题是如何有效地互连。问题互连性至关重要，只是相关生物学的一小部分可以存放在一个存储库中。 Flybase将继续历史性领导力在促进互连中的作用：通过工作与其他小组生产可以允许数据交换的软件在数据库之间以及通常通过共同努力来满足科学界的需求。