FLYBASE--A DROSOPHILA GENOMIC AND GENETIC DATABASE

Flybase——果蝇基因组和遗传数据库

• 批准号: 6660557
• 负责人: WILLIAM MARTIN GELBART
• 金额: $ 8.85万
• 依托单位: HARVARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-08-01 至 2003-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6660557
• 关键词: Drosophilidae; RNA; chromosomes; clone cells; complementary DNA; computer human interaction; computer program /software; genome; molecular biology information system; nucleic acid sequence; transposon /insertion element

The fruit fly, Drosophila, is one of the most important model organisms for many aspects of modern biological research, especially for issues regarding the biology of metazoa. Comparative studies have clearly demonstrated that the metabolic, cellular, and developmental regulatory networks are highly conserved within the animal kingdom, and in many cases, even to other taxa. Particularly because of the sophisticated genetics of the fruit fly, Drosophila melanogaster, the best-studied drosophilid species, it has led the way in elucidating many of the pathways. Much work in mammalian systems, especially the mouse and humans, has been completely based on the strong foundation that Drosophila research has provided. We are now at the point were we are beginning to understand the physiological roles of many of the roles that, when mutated, contribute to human disease. In many cases, the insights emerge largely from work on the Drosophila cognates of these genes. To take maximum advantage of the information of the information available for Drosophila, both for the Drosophila, both for the Drosophila researcher and for scientists working on other organisms, it is essential that data on the fly be organized and accessible to the broad biological community. This is the role of the Flybase Consortium. In this application, FlyBase requests 5 years of funding to continue its effort to provide the scientific community with the essential genomic and genetic information on D. melanogaster, and other drosolipids. This information will continue to be readily accessible on-line through the Flybase WWW server, mirrored at several sites throughout the world. An important new aspect of the project is the merger of the public informatics teams of the Berkeley and European Drosophila Genome Projects with the original FlyBase group to become an expanded FlyBase Consortium. This new FlyBase Consortium will provide the community with a completely unified view of all Drosophila genetic and genomic data from the whole organism and population structure information down to the sequence level. The expanded project will involve close coordination among the 5 participating sites of data capture, management, organization and presentation. Important features for the research community will be a re-organization of the WWW server and a implementation of a variety of new tools, including many Java-based graphical displays. One issue for the biological databases to address is how to interconnect effectively among themselves. Issue of interconnectivity are crucial, as only a fraction of the relevant biology can be housed in a single repository. FlyBase will continue in its historic leadership role in promoting interconnections: through working with other groups to produce software that will permit data exchange between databases, and generally through contributing to a joint effort to address the needs of the scientific community.

果蝇果蝇是最重要的模型生物之一 对于现代生物学研究的许多方面，尤其是针对问题 关于后生动物的生物学。比较研究显然 证明了代谢，细胞和发育调节 网络在动物王国内是高度保守的，在许多人中 案例，甚至是其他分类单元。特别是因为复杂的 果蝇的遗传学，果蝇Melanogaster，最研究的 果蝇物种，它领先于阐明许多 途径。在哺乳动物系统中，尤其是老鼠和人类中的许多工作 完全基于果蝇的强大基础 研究提供了。我们现在正在开始 了解许多角色的生理角色 突变，有助于人类疾病。在许多情况下，见解出现 主要是从这些基因的果蝇同源的工作。服用 可用信息的信息的最大优势 果蝇的果蝇，都是果蝇研究人员 对于从事其他生物的科学家来说，数据至关重要 在宽阔的生物群落中可以组织并可以使用。 这是Flybase联盟的作用。在此应用中，flybase 要求提供5年的资金，以继续努力提供 具有基本基因组和遗传信息的科学界 D. Melanogaster和其他drosolipids。这些信息将继续 可以轻松地通过Flybase www服务器在线访问，在 全世界的几个站点。一个重要的新方面 项目是伯克利公共信息团队的合并 欧洲果蝇基因组与原始的飞箱组计划 成为一个扩大的飞箱财团。这个新的飞箱财团将 为社区提供所有果蝇的完全统一的看法 来自整个生物体和种群结构的遗传和基因组数据 信息降至序列水平。扩展的项目将涉及 在5个参与数据捕获的站点之间密切的协调， 管理，组织和演示。重要功能 研究社区将是www服务器的重组和 实施各种新工具，包括许多基于Java 图形显示。生物数据库要解决的一个问题是 如何有效地互连。问题 互连性至关重要，只是相关生物学的一小部分 可以存放在一个存储库中。 Flybase将继续 历史性领导力在促进互连中的作用：通过工作 与其他小组生产可以允许数据交换的软件 在数据库之间以及通常通过共同努力来 满足科学界的需求。