AEROBIC EXERCISE--EFFECTS ON PHYSICAL SYMPTOMS OF HIV

有氧运动——对艾滋病毒身体症状的影响

• 批准号: 2258011
• 负责人: BARBARA ANN Smith
• 金额: $ 10万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-30 至 1997-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2258011
• 关键词: HIV infections; aerobic exercise; biomarker; clinical depression; human subject; mood disorders; sign /symptom

This study proposes to examine the effects of a 12 week low-moderate intensity aerobic exercise program on selected disease-related outcomes in patients with HIV but without CDC-defined AIDS.Outcome measures include assessments of physical symptoms; immune markers; depression; mood states and aerobic power. This is an important study. The aims are clearly stated, with variables identified, defined, and operationalized in exceptional detail. The review of the literature is comprehensive, current and analytic.Earlier work by the investigators serves as a firm foundation for the proposed study. The independent variable and all dependent variables are identified, defined, and operationalized. Inclusion/exclusion criteria are provided, most of which are appropriate. This study has numerous strengths all of which are not mentioned above but are fairly accurately discussed in the reviewers' comments. Some of the key weaknesses concern the sample size; feasibility and generalizability; the ability of the measures to detect clinically meaningful change over time; and the antiretroviral stratification. While the outcome measures are appropriate and could yield significant information, there are also some concerns related to the enrollment of control subjects in the experimental treatment before long-term outcomes are assessed, and the need to adequately monitor for the potential adverse effects of the treatment. There are also lesser concerns about the usefulness of measuring three of the extraneous variables. The team as a whole is highly competent to perform this research. Appropriate consultants have been chosen to assist with statistical analyses and data interpretation. Laboratory resources for this project are very appropriate including exercise testing and training facilities, clinical evaluation sites, and the laboratory for immunophenotyping.

这项研究建议检查12周低点的影响 强度有氧运动计划在某些疾病相关结果上 在艾滋病毒但没有CDC定义的艾滋病的患者中。 包括对身体症状的评估；免疫标记；沮丧; 情绪状态和有氧力量。 这是一项重要的研究。 目的 清楚地说明了变量，定义，并且 以特殊的细节进行操作。 文学的评论是 研究人员的全面，当前和分析。 是拟议研究的坚定基础。 独立 可变和所有因变量被识别，定义，并且 运营。 提供了包含/排除标准，大部分 合适的。 这项研究具有许多优势 在上面没有提及，但在 审稿人的评论。 一些关键弱点涉及样本 尺寸;可行性和普遍性； 措施的能力 随着时间的流逝，检测临床上有意义的变化； 和抗逆转录病毒 分层。 虽然结果措施是适当的，并且可以 产生大量信息，也有一些有关 在实验治疗中，对照对象的注册 评估了长期结果，并需要充分监视 治疗的潜在不利影响。 也有较少的 对测量三个无关的有用性的担忧 变量。 整个团队都有很高的能力进行这项研究。 选择了适当的顾问来协助统计 分析和数据解释。 该项目的实验室资源 非常合适，包括运动测试和培训设施， 临床评估地点和免疫表型实验室。