AEROBIC EXERCISE--EFFECTS ON PHYSICAL SYMPTOMS OF HIV

有氧运动——对艾滋病毒身体症状的影响

基本信息

批准号：
2356740
负责人：
BARBARA ANN Smith
金额：
$ 3.11万
依托单位：
OHIO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1994
资助国家：
美国
起止时间：
1994-09-30 至 1998-10-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/2356740
关键词：
HIV infections aerobic exercise biomarker clinical depression human subject mood disorders sign /symptom

项目摘要

Aerobic exercise shows considerable promise as an intervention nurses and other health care professionals can recommend for HIV infected adults, with recent studies linking structured aerobic exercise training to improved physical, psychological, and immune system outcomes. Research remains preliminary, however, and further exploration of the effects of aerobic exercise training on HIV disease progression and symptoms is needed prior to developing guidelines for health promotion/health maintenance programs. This study examines the effects of a 12 week aerobic exercise training protocol on physical symptoms; immune markers; psychological depression; mood states; and aerobic power in HIV infected adults (CD4 200-499) without CDC-defined AIDS. This study is structured as an experimental study (two group, pre-test control group design) with the exercise group (n=30) to aerobically exercise 1 hour, 3 times per week, for 12 consecutive weeks. The control group (n=30) is to maintain usual activities, monitored by bi-weekly telephone or clinic contract. Subjects will be recruited through The Ohio State University (OSU) AIDS Clinical Trials Unit (ACTU) and will be main- streamed with The OSU Cardiac Rehabilitation and Faculty/Staff fitness program for the exercise protocol. Dependent variables of physical symptoms (energy imbalance/fatigue, dyspnea, and weight loss/body composition), immune markers (immune system cell counts and delated-type hypersensitivity (DTH) testing, psychological depression, mood states, and aerobic power (oxygen uptake, VO2- MAX) will be measured at baseline (pre-test) and at 12 weeks (post-test), with descriptive follow-up of subject outcomes continuing at 24 and 48 weeks. Data for pre-test to 12 weeks (post-test) will be analyzed using ANCOVA with pre-Test values entered as a covariate. Confounding effects of anti-retroviral medications are controlled through pre-randomization stratification; other potential confounders will be monitored and controlled as appropriate. This study will supply important data on effects of aerobic exercise on symptoms experienced by HIV infected adults with mid-stage disease (CD4 200-499) and will provide empirically based guidelines for use by nurses in designing health promotion/maintenance programs for this population.

有氧运动作为干预护士和其他医疗保健专业人员可以推荐给艾滋病毒感染的成年人，最近的研究将结构化的有氧运动训练与改善了身体，心理和免疫系统的结果。研究但是，仍然是初步的，并进一步探索关于HIV疾病进展和症状的有氧运动训练是在制定健康促进/健康指南之前需要维护计划。这项研究检查了12周的影响有氧运动训练方案关于身体症状；免疫标记；心理抑郁；情绪状态；感染了艾滋病毒的有氧力量没有CDC定义的艾滋病的成人（CD4 200-499）。这项研究的结构是一项实验研究（两组，预测试对照组设计）与运动组（n = 30）进行有氧运动组（n = 30）练习1小时，每周3次，连续12周。控件组（n = 30）是要维护常规活动，每两周监视电话或诊所合同。主题将通过俄亥俄州招募州立大学（OSU）AIDS临床试验部（ACTU），将是主要的用OSU心脏康复和教职员工健身播出锻炼方案计划。物理的因变量症状（能量不平衡/疲劳，呼吸困难和体重减轻/身体组成），免疫标记物（免疫系统细胞计数和粉状类型高敏性（DTH）测试，心理抑郁，情绪状态，和有氧功率（氧气吸收，vo2-最大）将在基线时测量（预测试）和12周（测试后），并进行描述性随访主题结果在24和48周持续。预测试到12的数据几周（测试后）将使用带有测试前值的ANCOVA分析作为协变量进入。抗逆转录病毒的混杂作用药物是通过随机前分层控制的；其他潜在的混杂因素将被监视和控制合适的。这项研究将提供有关有氧运动对的重要数据艾滋病毒感染的成年人中期疾病经历的症状（CD4 200-499），并将提供基于经验的指南以供护士使用在为该人群设计健康促进/维护计划时。