A Physical Activity & Nutrition Intervention in HIV

体力活动

• 批准号: 6834228
• 负责人: BARBARA ANN Smith
• 金额: $ 18.53万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-30 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6834228
• 关键词: AIDS therapy; HIV infections; antiAIDS agent; blood glucose; blood lipid; body composition; combination chemotherapy; combination therapy; diet therapy; drug adverse effect; exercise; human subject; human therapy evaluation; insulin; lipodystrophy; nutrition related tag; patient oriented research

DESCRIPTION: Although the use of potent antiretrovirals has improved mortality and morbidity associated with HIV-1 infection, new constellations of side effects continue to challenge nurses and other providers. One new syndrome associated with the antiretroviral therapy, lipodystrophy or fat redistribution, includes peripheral wasting, central fat accumulation, elevated blood lipids, glucose and insulin and places patients at risk for cardiovascular disease, diabetes, pancreatitis and may influence adherence to drug therapy; thus, the management of troubling side effects and symptoms such as lipodystrophy has taken on new importance and underscores the need to examine strategies that may attenuate or alleviate these side effects/symptoms. Subsequent work will need to focus on the prevention of the syndrome once strategies for managing the syndrome(s) have been identified. The purpose of the proposed study is to examine the effects of a 16-week integrated intervention designed to improve body composition, blood lipids and metabolic variables in HIV-1 infected individuals who are enrolled in NIH funded clinical trials of highly active antiretroviral therapy (HAART) and who are experiencing lipodystrophy. The intervention consists of three major components: physical activities intended to increase cardiorespiratory endurance, physical activities that will enhance strength, flexibility and increase cross-sectional area of muscle, and a nutrition component. Each component of the intervention is intended to improve some aspect of the lipodystrophy syndrome and is consistent with the Healthy People 2010. This experimental study will use a 2-group design with subjects in the experimental group (n=42) encouraged to accumulate 30 minutes of physical activity most if not all days of the week and set measurable dietary goals with the dietitian. Subjects in the control group (n=42) will maintain usual activity and usual diet for 16 weeks and then enter the intervention phase of the project. Subjects will be recruited from the ALLRT protocol or FRAM study at the UAB Outpatient HIV Clinic. A two by two, mixed model ANCOVA will be used to test study hypotheses related to body composition, blood lipids, glucose, insulin and C-peptide. Data from the study will be used to develop evidence-based guidelines for advanced practice nurses, dietitians, physicians and other health care providers to assist patients in managing lipodystrophy associated with HIV-1 therapies.

描述：尽管使用有效的抗逆转录病毒已经提高了死亡率 与HIV-1感染相关的发病率，侧面的新星座 效果继续挑战护士和其他提供者。一种新综合征 与抗逆转录病毒疗法，脂肪营养不良或脂肪有关 重新分布，包括外围浪费，中央脂肪积累，升高 血脂，葡萄糖和胰岛素，使患者处于风险 心血管疾病，糖尿病，胰腺炎，可能会影响依从性 药物治疗；因此，管理令人不安的副作用和症状这样的管理 由于脂肪营养不良提出了新的重要性，并强调了 检查可能减弱或减轻这些副作用/症状的策略。 随后的工作将需要专注于预防综合症 已经确定了管理综合征的策略。目的 拟议的研究是检查16周整合的影响 干预措施旨在改善身体成分，血脂和代谢 在NIH资助的临床中，HIV-1感染的个体中的变量 高度活跃的抗逆转录病毒疗法（HAART）的试验 脂肪营养不良。干预措施包括三个主要组成部分：物理 旨在增加心肺耐力，身体的活动 将提高力量，灵活性并增加横截面的活动 肌肉区域和营养成分。干预的每个组成部分 旨在改善脂肪营养不良综合征的某些方面，是 与2010年健康人一致。这项实验研究将使用 在实验组中具有主题的2组设计（n = 42）。 累积30分钟的体育活动，甚至一周中的整天， 用营养师设定可衡量的饮食目标。对照组的受试者 （n = 42）将维持通常的活动和通常的饮食习惯16周，然后进入 项目的干预阶段。主题将从 UAB门诊HIV诊所的AllRT方案或FRAM研究。一个两个乘 混合模型ANCOVA将用于测试与身体有关的假设 组成，血脂，葡萄糖，胰岛素和C肽。研究的数据 将用于为高级实践护士制定基于证据的准则， 营养师，医生和其他医疗保健提供者为患者提供帮助 管理与HIV-1疗法相关的脂肪营养不良。