EMF EFFECTS ON MELATONIN AMONG AGING VOLUNTEERS

电磁场对老年志愿者褪黑激素的影响

• 批准号: 2331608
• 负责人: DANIEL Frederick KRIPKE
• 金额: $ 7.05万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-01-15 至 1998-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2331608
• 关键词: aging; circadian rhythms; clinical research; human middle age (35-64); human mortality; human old age (65+); human subject; magnetic field; melatonin; mood disorders; radiobiology; sleep disorders; urinalysis

This is a small grant proposal in response to RFA ES-06-007, "Biological effects of power frequency EMF." It has been hypothesized that EMF (electro-magnetic fields) may suppress melatonin, and through this mechanism, EMF might mediate morbidity and mortality. The problem may be particularly severe for elderly people who have low melatonin. The hypothesis that melatonin prevents aging, e.g., aging related to free-radical damage and cancer, has recently received sensational news coverage. Millions of Americans fearful of melatonin deficiency may be buying products from health food stores labeled as melatonin. The investigators propose to critically test whether EMF in the bedroom influences daily melatonin excretion. This small grant will permit the investigators to collect home EMF recordings to combine with data being collected for other projects on melatonin excretion and bedtime light levels. The correlation of EMF resultant vector strength and nightly melatonin excretion will be determine, to establish if EMF could be a substantial regulator of melatonin production. Statistical controls for age, gender, light levels, and drug intake will be implemented. This study will establish whether EMF could be an important source of variance in melatonin excretion. In conjunction with ongoing studies, possible indirect EMF effects through melatonin on morbidity and mortality will be considered.

这是对RFA ES-06-007的一项小型赠款建议， “功率EMF的生物学效应”。 它已被假设 EMF（电磁场）可能会抑制褪黑激素，并通过 这种机制，EMF可能介导发病率和死亡率。问题 对于褪黑激素低的老年人来说，可能特别严重。 褪黑激素阻止衰老的假设，例如 自由基损害和癌症，最近收到了轰动的新闻 覆盖范围。 数以百万计的美国人担心褪黑激素缺乏可能 是从标有褪黑激素的保健食品商店购买产品。 这 调查人员建议批判性地测试卧室的电动势 影响每日褪黑激素排泄。 这笔小赠款将允许 调查人员收集家庭EMF录音以与数据结合 被收集到有关褪黑激素排泄和就寝时间的其他项目 光线水平。 EMF产生的向量强度和 每晚都将确定褪黑激素排泄，以确定是否EMF 可能是褪黑激素产生的实质性调节剂。 统计 年龄，性别，光水平和药物摄入的控制 实施的。 这项研究将确定EMF是否可以是 褪黑激素排泄的重要方差来源。 结合 通过正在进行的研究，可能通过褪黑激素的间接EMF效应 将考虑有关发病率和死亡率。