PHASE RESPONSE CURVES FOR EXERCISE AND BRIGHT LIGHT

运动和强光的相位响应曲线

• 批准号: 2909323
• 负责人: DANIEL Frederick KRIPKE
• 金额: $ 54.29万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-08-01 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2909323
• 关键词: age difference; body temperature; circadian rhythms; clinical research; exercise; gender difference; human old age (65+); human subject; melatonin; photostimulus; sleep; urinalysis; young adult human (21-34)

DESCRIPTION (adapted from investigator's abstract): The investigator's laboratory has discovered an appalling prevalence of malsynchronization of circadian rhythms among volunteers averaging 70 years of age. Aging people may be abnormally resistant to the circadian synchronizing effects of bright light. If so, we may need to develop alternative methods by which older Americans can synchronize their circadian rhythms to the environment. Recent studies indicate that exercise may shift circadian rhythms in young adults, but nothing is known about the value of exercise for regulating circadian rhythms in the aging population. It seems crucial to extend our understanding of exercise effects on the circadian system and, specifically, to compare the potential values of exercise and bright light for correcting the circadian malsynchronization of older Americans. The project will establish circadian phase response curves both for exercise and for bright light in 96 volunteers, ages 18-30 plus 128 older volunteers ages 60-75 years. Volunteers will be recorded for 4.8 to 4.6 days while following an ultra-short sleep-wake cycle, consisting of 30 minutes for sleeping, followed by 60 minutes for waking. Baseline circadian phases of urinary 6-sulphatoxymelatonin, urinary free cortisol, temperature and sleep propensity will be assessed every 90 min. Oral temperature will be sampled every 30 min. Volunteers will be given experimental phase-shifting treatments (exercise or bright light) for 3 days. Resultant circadian phases will then be determined to compute the phase response curves, in order to examine interactions of stimulus (exercise vs. light), age, and gender on circadian responsiveness.

描述（根据调查员的摘要改编）：调查员的 实验室发现了令人震惊 志愿者的昼夜节律平均年龄为70岁。老年人可能 异常抵抗明亮光的昼夜节律同步作用。 如果是这样，我们可能需要开发替代方法 将其昼夜节律同步到环境。最近的研究表明 该练习可能会改变年轻人的昼夜节律，但没有什么已知的 关于调节衰老中昼夜节律的锻炼价值 人口。扩展我们对运动影响的理解似乎至关重要 昼夜节律系统，特别是为了比较 锻炼和明亮的光，以纠正昼夜节律 年长的美国人。该项目将建立昼夜节相响应曲线 在96名志愿者中，锻炼和明亮的光线，年龄在18-30岁的志愿者中 年龄较大的60-75岁志愿者。志愿者将记录为4.8至4.6 遵循超短睡眠周期的几天，包括30分钟 为了睡觉，然后进行60分钟以唤醒。基线昼夜阶段 尿液6-磺破合蛋白酶，尿自由皮质醇，温度和睡眠 倾向将每90分钟评估一次。口服温度将进行采样 每30分钟一次。志愿者将获得实验性相位治疗 （运动或明亮的光）3天。由此产生的昼夜阶段将是 确定计算相响应曲线，以检查 在昼夜节律上的刺激（练习与光），年龄和性别的相互作用 响应能力。