RESPONSIVENESS OF THE AGING CIRCADIAN CLOCK TO LIGHT

老化生物钟对光的反应

• 批准号: 6391006
• 负责人: SUSAN J BENLOUCIF
• 金额: $ 22.05万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-30 至 2005-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6391006
• 关键词: age difference; biological clocks; body temperature; chronotherapy; circadian rhythms; clinical research; hormone regulation /control mechanism; human middle age (35-64); human old age (65+); human subject; melatonin; nimodipine; photostimulus; phototherapy; sleep disorders; thyrotropin; young adult human (21-34)

DESCRIPTION (adapted from investigator's abstract): The investigator's long-term goal is to understand the basis of and develop effective therapies for chronic sleep disturbances in older adults. One common sleep disorder in older adults is advanced sleep phase, accompanied by sleep maintenance insomnia and early morning awakenings. This can shorten the total sleep time and lead to daytime fatigue and impaired performance. The advance in sleep is associated with an advances in the timing of the circadian core body temperature rhythm which suggests an advance in the timing of the circadian clock. The cause of this advance is unknown. Preliminary date from the investigators laboratory suggests that elderly subjects do not phase delay following exposure to 4000 lux for 3 hours before the temperature minimum, a time that usually does delay the rhythm in younger adults. The first goal of this application is to understand the mechanism underlying the age-related change in responsiveness of the clock to light. The second goal is to assess whether it is possible to compensate for age-related change in the responsiveness of the aging circadian clock to light by either increasing the intensity of the light exposure or by pharmacological treatment with the calcium channel antagonist nimodipine. The proposed experiments will provide a vast amount of data in which to better understand the effect of age on circadian rhythms and sleep and lead to improved treatments for circadian rhythm and sleep disorders in older adults.

描述（根据调查员的摘要改编）：调查员的 长期目标是了解和开发有效疗法的基础 对于老年人的慢性睡眠障碍。一种常见的睡眠障碍 老年人是晚期睡眠阶段，伴随着睡眠失眠症 和清晨觉醒。这可能会缩短总睡眠时间并导致 白天疲劳和性能受损。睡眠的前进是相关的 随着昼夜节律体温节奏的进步 这表明在昼夜节律时钟的时机中有所进步。原因 此进步是未知的。调查人员实验室的初步日期 表明老年受试者在暴露于4000的情况下不会相位延迟 lux在温度最低之前3小时，通常会延迟 年轻人的节奏。该应用程序的第一个目标是 了解与年龄相关的响应变化的基础机制 时钟点亮。第二个目标是评估是否有可能 弥补与年龄相关的变化的变化 通过增加光曝光的强度或通过 钙通道拮抗剂二胺的药理治疗。这 拟议的实验将提供大量数据，以便更好 了解年龄对昼夜节律和睡眠的影响并导致 改善了老年人昼夜节律和睡眠障碍的治疗方法。