AUTOMATED INTERPRETATION OF PROTON MAGNETIC RESONANCE

质子磁共振的自动解释

• 批准号: 2035465
• 负责人: Dariusz Wroblewski
• 金额: $ 10万
• 依托单位: ORINCON CORPORATION
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-04 至 1998-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2035465
• 关键词: artificial intelligence; computational neuroscience; computer assisted diagnosis; computer program /software; computer system design /evaluation; diagnosis design /evaluation; electronic spectra; magnetic resonance imaging; nervous system disorder; nuclear magnetic resonance spectroscopy

Nuclear Magnetic Resonance Spectroscopy (MRS) offers unique chemical data, complementary to the anatomic information provided by the Magnetic Resonance Imaging (MRI), that adds a new dimension to the in vivo diagnosis of neurological disease. MRS is now emerging from the laboratory and exploratory clinical studies that have shown a wide range of possible clinical applications, ranging from critically ill neonates to dementia in the elderly. The widespread clinical application of this important new diagnostic will require development of fast and reliable automated tools for interpretation of the spectra in terms of metabolite concentrations and medical diagnosis. ORINCON proposes to develop MRS interpretation software based on a neural network model employing a database of spectra of single metabolites. In Phase I of this project, ORINCON will design and implement prototype software to estimate, from simulated, one-dimensional proton spectra of the brain, the concentrations of compounds that are important for diagnosis of neurological disorders. The ultimate goal, to be realized in Phase II of this program, is to implement the MRS analysis software that will, without intervention of the operator, interpret the brain MRS data in terms of the metabolite concentrations and probability of relevant diseases. The interpretation software will be compatible with presently used spectroscopy packages and will also be portable to a personal computer (PC) platform. PROPOSED COMMERCIAL APPLICATION: Software for automated analysis of NMR spectra of the brain will be a commercially viable product that can be distributed as a part of existing MRS packages. We anticipate that the interpretation software will be implemented within SageIDL - the MRS software package developed by GE Medical Systems for nuclear magnetic resonance image (MRI) scanners. The methods developed here may also find commercial application in medical diagnostic tools based on MRS of urine, cerebrospinal fluid, plasma, bile, semen, and amniotic fluid, as well as in atomic and molecular spectroscopy.

核磁共振波谱 (MRS) 提供独特的化学 数据，补充磁性提供的解剖信息 共振成像 (MRI)，为体内成像增添了新维度 神经系统疾病的诊断。 MRS现在正在从 实验室和探索性临床研究显示了广泛的 可能的临床应用，包括危重新生儿 导致老年人痴呆。此法临床应用广泛 重要的新诊断方法需要开发快速可靠的方法 用于解释代谢物光谱的自动化工具 浓度和医学诊断。 ORINCON提议开发MRS 基于神经网络模型的解释软件 单一代谢物的光谱数据库。在该项目的第一阶段， ORINCON 将设计并实施原型软件来估算， 大脑的模拟一维质子光谱 对诊断很重要的化合物浓度 神经系统疾病。最终目标将在第二阶段实现 这个程序是为了实现 MRS 分析软件， 无需操作员干预，即可解读大脑 MRS 数据 代谢物浓度和相关概率的术语 疾病。解释软件将兼容目前 使用过的光谱包，也可以随身携带到个人 计算机（PC）平台。 拟议的商业应用： 用于自动分析大脑核磁共振谱的软件将是一个 商业上可行的产品，可以作为一部分分发 现有的 MRS 套餐。我们预计解释软件 将在 SageIDL（开发的 MRS 软件包）内实施 由 GE 医疗系统提供核磁共振图像 (MRI) 扫描仪。这里开发的方法也可能商业化 基于尿液MRS的医疗诊断工具的应用， 脑脊液、血浆、胆汁、精液和羊水，以及 在原子和分子光谱学中。