ABCD-USA Consortium: Research Project

ABCD-美国联盟：研究项目

• 批准号: 9053241
• 负责人: Fiona C Baker
• 金额: $ 62.87万
• 依托单位: SRI INTERNATIONAL
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-30 至 2020-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9053241
• 关键词: 10 year old; Address; Adolescence; Adolescent; Adolescent Development; Age; Alcohol or Other Drugs use; Alcohols; American; Behavior; Behavior Therapy; Behavioral; Behavioral Genetics; Bioinformatics; Biological; Biological Assay; Brain; Brain imaging; Characteristics; Child; Child Development; Childhood; Chronobiology; Clinical; Clinical assessments; Communities; Data; Data Analyses; Data Collection; Development; Devices; Dose; Elements; Ensure; Environment; Epidemiology; Evaluation; Event; Family; Future; Genetic; Goals; Human; Human Development; Individual; Informatics; International; Interview; Lead; Life; Link; Longitudinal Studies; Magnetic Resonance Imaging; Marijuana; Measures; Mental Depression; Mental Health; Methodology; Methods; Monitor; Neurobiology; Neurocognition; Neurocognitive; Neuropsychological Tests; Online Systems; Outcome; Participant; Pathway interactions; Patient Self-Report; Pattern; Phenotype; Population; Procedures; Process; Psychopathology; Quality Control; Questionnaires; Recording of previous events; Recruitment Activity; Reporting; Research; Research Personnel; Research Project Grants; Resources; Risk; Role; Sampling; Site; Sleep; Social Functioning; Socioeconomic Status; Standardization; Surveys; Symptoms; Technology; Time; Twin Multiple Birth; Uncertainty; Wrist; Youth; actigraphy; adolescent substance use; age related; awake; base; behavioral health; cognitive development; cognitive testing; cohesion; computerized; design; early onset; emerging adult; experience; handheld mobile device; high risk; marijuana user; misuse of prescription only drugs; neuroimaging; novel; psychological outcomes; public health relevance; response; sex; success; temporal measurement; time use; trend

 DESCRIPTION (provided by applicant): Adolescence is a critical neurodevelopmental period associated with dramatic increases in rates of substance use. Identifying the pathways to substance use and its effects on child and adolescent development is critically important, as the effects of substance use during ongoing maturation likely have long-lasting effects on brain functioning and behavioral, health, and psychological outcomes. This Research Project Site application from SRI International is in response to RFA-DA-15-015 as part of the ABCD-USA Consortium (10/13), to prospectively determine the neurodevelopmental and behavioral predictors and consequences of substance use on children and adolescents. A representative community sample of 550 9-10 year olds enriched for high- risk characteristics will be recruited, contributing to the sample of 11,111 to be collected from 11 hubs across the ABCD-USA Consortium. All participants will undergo a comprehensive baseline assessment, including state-of-the-art brain imaging, comprehensive neuropsychological testing, bioassays, mobile monitoring and careful assessment of substance use, environment, psychopathological symptoms, and social functioning every 2 years. Interim annual interviews and quarterly web-based assessments will provide refined temporal resolution of behaviors, development, and life events with minimal participant burden. These Consortium-wide data obtained during the course of this project will elucidate: 1) the effects of substance use patterns on the adolescent brain; 2 the effects of substance use on behavioral and health outcomes; 3) the bidirectional relationship between psychopathology and substance use patterns; 4) the effects of individual genetic, behavioral, neurobiological, and environmental differences on risk profiles and substance use outcomes; and 5) the "gateway interactions" between use of different substances. Our project focuses on the sleep and chronobiology data collected across the consortium, both with questionnaires and periodic assessment with wearable wrist trackers. Our aims are to assess sleep behavior and chronotype as predictors of subsequent substance use, and to investigate the effects of current substance use on sleep characteristics in adolescents. We will also conduct exploratory analyses to determine the effect of marijuana usage on sleep, to evaluate relationships between sleep and chronobiology variables, substance use and development of depression; and to investigate genetic and environmental contributions to associations between sleep characteristics, chronotype and substance use in twins. The combination of careful assessment of subjective and objective sleep and chronotype, detailed evaluation of substance use patterns and sensitive clinical measures will provide a unique resource for the scientific community, and help guide age-appropriate behavioral interventions.

 描述（由申请人提供）：青春期是一个关键的神经发育时期，与物质使用率急剧增加相关，确定物质使用的途径及其对儿童和青少年发育的影响至关重要，因为物质使用对持续成熟的影响。 SRI International 的该研究项目网站申请是对 RFA-DA-15-015 的回应，作为 ABCD-USA 联盟的一部分。 (10/13)，将招募 550 名 9-10 岁儿童的代表性社区样本，以确定高风险特征，以前瞻性地研究神经发育和行为预测因素以及药物使用的后果，从而为样本做出贡献。将从 ABCD-USA 联盟的 11 个中心收集 11,111 份数据，所有参与者都将接受全面的基线评估，包括最先进的脑成像、全面的神经心理学测试、每两年对物质使用、环境、精神病理学症状和社会功能进行生物测定、移动监测和仔细评估，中期年度访谈和季度网络评估将为行为、发展和生活事件提供精确的时间分辨率，同时将参与者的负担降至最低。在该项目过程中获得的这些联盟范围内的数据将阐明：1）物质使用模式对青少年大脑的影响；2）物质使用对行为和健康结果的影响；3）精神病理学与物质之间的双向关系。使用模式；4）个体遗传、行为、神经生物学和环境差异对风险状况和物质使用结果的影响；5）不同物质使用之间的“网关相互作用”我们的项目重点关注收集的睡眠和时间生物学数据。我们将通过问卷调查和可穿戴手腕追踪器定期评估来评估睡眠行为和睡眠时间类型，作为后续药物使用的预测因素，并调查当前药物使用对青少年睡眠特征的影响。还进行探索性分析，以确定吸食大麻对睡眠的影响，评估睡眠与时间生物学变量、抑郁症的使用和发展之间的关系；并研究遗传和环境对双胞胎睡眠特征、时间类型和物质使用之间关系的影响。对主观和客观睡眠和睡眠时间类型的仔细评估、对物质使用模式的详细评估和敏感的临床测量相结合，将为科学界提供独特的资源，并有助于指导适合年龄的行为干预措施。