Emotion Regulation and Sleep in Alcohol Use Disorder

酒精使用障碍中的情绪调节和睡眠

• 批准号: 10254381
• 负责人: Fiona C Baker
• 金额: $ 27.38万
• 依托单位: SRI INTERNATIONAL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-05 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10254381
• 关键词: Abstinence; Adrenergic Agents; Affect; Affective; Age; Amygdaloid structure; Architecture; Attention; Brain; Chronic; Data; Disease; Emotional; Emotions; Equilibrium; Experimental Designs; Eye Movements; Female; Fracture; Functional Magnetic Resonance Imaging; Gender; Homeostasis; Impairment; Individual; Knowledge; Lead; Link; Literature; Magnetic Resonance Imaging; Measures; Mission; Modeling; National Institute on Alcohol Abuse and Alcoholism; Neural Pathways; Neurobiology; Pathway interactions; Patients; Pharmacotherapy; Polysomnography; Prefrontal Cortex; Process; Protocols documentation; REM Sleep; Recovery; Regulation; Relapse; Research; Research Personnel; Role; Sleep; Sleep disturbances; Slow-Wave Sleep; Structure; System; United States; Woman; alcohol craving; alcohol use disorder; behavior measurement; cholinergic; chronic alcohol ingestion; craving; design; disorder control; disorder later incidence prevention; emotion regulation; emotional functioning; emotional stimulus; functional MRI scan; health related quality of life; imaging modality; improved; indexing; male; men; multidisciplinary; neuroimaging; novel; poor sleep; pressure; prevent; rapid eye movement; relapse prediction; relating to nervous system; sex; sleep physiology; sleep quality; sleep regulation; success; tool development

PROJECT SUMMARY/ABSTRACT Alcohol use disorder (AUD) is a multifaceted, chronic relapsing disorder suffered by millions of men and women in the United States. AUD is associated with disrupted sleep continuity and architecture, including an abnormally high level of rapid eye movement (REM) sleep that persists long into abstinence, and which is a significant predictor of relapse. Emotion deficits, including affective flattening and mesocorticolimbic hypo-responsiveness to emotional stimuli, are consistent findings in AUD and also predict relapse. Here, we bring these two components together, building on an emerging literature showing that REM sleep is important for neural emotion regulation, calibrating emotions to promote next-day adaptive emotional functioning. We propose that the REM sleep-emotion pathway is dysfunctional in AUD, contributing to the deficits in emotion regulation in AUD shown by us and others, which lead to increased craving and relapse. Here, multidisciplinary researchers (Baker, Műller-Oehring) with combined expertise in AUD, sleep, fMRI, and emotion, aim to investigate the role of REM sleep in next-day emotional functioning in AUD. A novel counterbalanced, mixed-measures experimental design is applied in abstinent male and female AUD patients compared to age- and gender-matched healthy controls, all undergoing two experimental night conditions: uninterrupted sleep and selective REM sleep reduction, each followed by functional neuroimaging with emotion reactivity and emotion regulation tasks the following morning. We aim to (1) Determine relationships between REM sleep qualities (duration and intensity) and next-day neural emotional reactivity in AUD; (2) Determine specific effects of experimental REM sleep reduction on next-day neural emotional reactivity in AUD compared to healthy controls and compared to an uninterrupted sleep condition. We will also explore to what extent the sleep-emotion regulation link is adjustable with a REM sleep reduction protocol towards a more functionally-intact system that contributes to normalization of behavioral measures of emotion functioning and less alcohol craving in AUD. These studies open up new avenues into a mechanistic understanding of links between sleep processes and emotional brain function in AUD. Findings will inform a R01 application aimed at investigating the effects of sleep manipulation as a pathway to reset neural emotion regulation circuits, fracture the cycle of relapse, and improve management of AUD.

项目概要/摘要 酒精使用障碍 (AUD) 是一种多方面的慢性复发性疾病，数百万男性和女性都患有这种疾病 在美国，AUD 与睡眠连续性和结构紊乱有关，包括睡眠异常。 高水平的快速眼动 (REM) 睡眠持续很长时间直至戒断，这是一个重要的 情绪缺陷，包括情感扁平和中皮质边缘反应低下。 与情绪刺激的相关性，在 AUD 中是一致的，并且也预测复发。在这里，我们带来这两个。 新兴文献表明快速眼动睡眠对神经情绪很重要 调节、校准情绪以促进第二天的适应性情绪功能。 我们认为，AUD 中的 REM 睡眠情绪通路功能失调，导致情绪缺陷 我们和其他人展示了澳元的监管，这导致了渴望的增加和复发。 在这里，多学科研究人员（Baker、Műller-Oehring）拥有 AUD、睡眠、功能磁共振成像和 情绪，旨在研究快速眼动睡眠在 AUD 第二天情绪功能中的作用。 平衡的混合测量实验设计应用于禁欲的男性和女性 AUD 患者 与年龄和性别匹配的健康对照组相比，所有对照组都经历了两种实验夜间条件： 不间断睡眠和选择性快速眼动睡眠减少，随后进行带有情绪的功能性神经影像学检查 第二天早上的反应和情绪调节任务。 我们的目标是 (1) 确定快速眼动睡眠质量（持续时间和强度）与第二天神经元之间的关系 以 AUD 为单位的情绪反应；(2) 确定实验性快速眼动睡眠减少对第二天的具体影响 与健康对照以及与不间断睡眠相比的神经情绪反应（AUD） 我们还将探讨快速眼动睡眠在多大程度上可以调节睡眠-情绪调节联系。 减少协议，建立一个功能更完整的系统，有助于行为正常化 衡量情绪功能和减少饮酒渴望的指标（澳元）。 这些研究为从机制上理解睡眠过程和睡眠过程之间的联系开辟了新途径。 AUD 中的情绪脑功能的研究结果将为旨在研究睡眠影响的 R01 应用程序提供信息。 操纵作为重置神经情绪调节回路、打破复发循环和改善的途径 澳元管理。