The Philadelphia Regional Stroke Trials Network Coordinating Center (PRSTNCC)

费城地区卒中试验网络协调中心 (PRSTNCC)

• 批准号: 10851524
• 负责人: SCOTT E KASNER
• 金额: $ 15.04万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10851524
• 关键词: Academic Medical Centers; Acute; Adult; Age; Area; Blood Vessels; Cause of Death; Child; Childhood; Clinical; Clinical Trials; Clinical Trials Design; Conduct Clinical Trials; Data Collection; Disease; Education; Emergency Department Physician; Feedback; Funding; Generations; Geography; Goals; Hospitals; Infrastructure; Knowledge; Leadership; Neurologist; Neurosurgeon; Participant; Patients; Pediatric Hospitals; Pennsylvania; Philadelphia; Prevention; Prevention therapy; Principal Investigator; Public Health; Recovery; Rehabilitation therapy; Research; Research Personnel; Research Support; Rhode Island; Scientist; Specialist; Stroke; Training; Translational Research; United States; United States National Institutes of Health; Universities; career; clinical practice; data exchange; ethnic diversity; experience; human subject protection; member; multidisciplinary; novel therapeutics; participant enrollment; skills; stroke clinical trials; stroke intervention; stroke therapy; stroke trials; tertiary care

PROJECT SUMMARY/ABSTRACT The Philadelphia Regional Stroke Trials Network Coordinating Center (PRSTNCC) is a highly effective collaborative stroke research team comprised of adult and pediatric vascular neurologists, neurosurgeons, neuroradiologists, emergency physicians, rehabilitation specialists, and other experts who conduct clinical trials focused on stroke treatment, prevention, and recovery. The PRSTNCC is based at the University of Pennsylvania (Penn), an urban, tertiary care, academic medical center in Philadelphia, PA, which serves as the "Hub" of the consortium, and has joined forces with the Children's Hospital of Philadelphia (CHOP) and 8 additional member hospitals ("Spokes") located in geographically and ethnically diverse areas in and around Philadelphia (and 1 in Rhode Island). The PRSTNCC thereby unites comprehensive stroke centers, primary stroke centers, and a regional pediatric center, providing access to a broad range of patients with stroke to a multidisciplinary group of clinicians and researchers. The overarching goal of the PRSTNCC is to reduce the burden of stroke among patients of all ages and backgrounds within this region by conducting interdisciplinary trials of promising clinical interventions for stroke treatment, prevention, and recovery. The multi-disciplinary PRSTNCC leadership team, led by Principal Investigator (PI) Scott E. Kasner, MD, has extensive experience conducting multi-center stroke clinical trials, and has been a leading enroller for the current NIH StrokeNet. The PRSTNCC infrastructure supports efficient and effective conduct of stroke trials among the participant hospitals. Research support and expertise are provided by the Hub, particularly in the areas of human subjects protections and other regulatory activities, and education and orientation of clinical and research staff in an effort to streamline trial implementation and expedite patient enrollment. The Hub provides ongoing support for data collection and transfer during trial execution, and provides timely feedback and education about trial results to member specialists and hospitals to encourage translation of research results into clinical practice. In addition, we are training a new generation of stroke researchers in the conduct and design of clinical trials by providing them with the knowledge and skills necessary for a successful academic career as independently-funded clinician-scientists.

项目摘要/摘要 费城地区中风试验网络协调中心（PRSTNCC）是一个非常有效的 合作中风研究小组由成人和小儿血管神经科医生，神经外科医生组成 神经放射学家，急诊医生，康复专家以及其他进行临床试验的专家 专注于中风治疗，预防和恢复。 PRSTNCC位于大学 宾夕法尼亚州费城的学术医学中心，宾夕法尼亚州的宾夕法尼亚州（宾夕法尼亚州），宾夕法尼亚州 财团的“枢纽”，并与费城儿童医院（Chop）和8 位于地理和种族多元化地区的其他会员医院（“辐条”）及其周边地区 费城（在罗德岛州1）。 PRSTNCC因此团结了全面的中风中心，主要中心 中风中心和区域小儿中心，可通往广泛的中风患者 临床医生和研究人员的多学科小组。 PRSTNCC的总体目标是减少 通过跨学科的所有年龄段和背景患者的中风负担 有望进行中风治疗，预防和恢复的有希望的临床干预试验。 由首席研究员（PI）Scott E. Kasner，医学博士领导的多学科PRSTNCC领导团队已有 进行多中风临床试验的丰富经验，一直是 当前的NIH Strokenet。 PRSTNCC基础架构支持中风试验的有效行为 在参与医院中。研究支持和专业知识由中心提供，特别是在 人类受试者保护和其他监管活动的领域以及临床的教育和方向 和研究人员努力简化试验实施并加快患者入学率。集线器 在试用执行过程中提供对数据收集和转移的持续支持，并提供及时的反馈 以及对成员专家和医院的试验结果的教育，以鼓励翻译研究 结果临床实践。此外，我们正在培训新一代的中风研究人员 和设计临床试验，通过为成功提供成功的知识和技能来设计 作为独立资助的临床医生的学术生涯。