The Philadelphia Regional Stroke Trials Network Coordinating Center (PRSTNCC)

费城地区卒中试验网络协调中心 (PRSTNCC)

基本信息

批准号：
9983211
负责人：
SCOTT E KASNER
金额：
$ 32.2万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-15 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9983211
关键词：
Academic Medical Centers Acute Adult Age Area Blood Vessels Cause of Death Cerebrovascular Disorders Certification Child Childhood Clinical Clinical Research Clinical Trials Clinical Trials Design Communication Conduct Clinical Trials Data Collection Development Discipline Disease Education Emergency Department Physician Enrollment Feedback Funding Future Generations Geography Goals Hospitals Infrastructure Intervention Knowledge Leadership Mentors Mission Monitor Neurologist Neurosurgeon Nurses Participant Patient Recruitments Patients Pediatric Hospitals Pennsylvania Phase Philadelphia Prevention Prevention therapy Principal Investigator Procedures Productivity Protocols documentation Public Health Recovery Rehabilitation therapy Research Research Ethics Research Personnel Research Project Grants Research Support Research Training Resources Rhode Island Scientist Site Specialist Stroke StrokeNet trials Structure Surgeon Talents Time Training Training and Education Translational Research United States United States National Institutes of Health Universities Work base career clinical practice data exchange data management ethnic diversity experience follow-up human subject protection innovation member multi-site trial multidisciplinary neonate novel therapeutics operation patient population programs recruit skills stroke clinical trials stroke intervention stroke patient stroke therapy stroke trials suburb tertiary care

项目摘要

The Philadelphia Regional Stroke Trials Network Coordinating Center (PRSTNCC) is a highly effective collaborative stroke research team comprised of adult and pediatric vascular neurologists, neurosurgeons, neuroradiologists, emergency physicians, rehabilitation specialists, and other experts who conduct clinical trials focused on stroke treatment, prevention, and recovery. The PRSTNCC is based at the University of Pennsylvania (Penn), an urban, tertiary care, academic medical center in Philadelphia, PA, which serves as the "Hub" of the consortium, and has joined forces with the Children's Hospital of Philadelphia (CHOP) and 8 additional member hospitals ("Spokes") located in geographically and ethnically diverse areas in and around Philadelphia (and 1 in Rhode Island). The PRSTNCC thereby unites comprehensive stroke centers, primary stroke centers, and a regional pediatric center, providing access to a broad range of patients with stroke to a multidisciplinary group of clinicians and researchers. The overarching goal of the PRSTNCC is to reduce the burden of stroke among patients of all ages and backgrounds within this region by conducting interdisciplinary trials of promising clinical interventions for stroke treatment, prevention, and recovery. The multi-disciplinary PRSTNCC leadership team, led by Principal Investigator (PI) Scott E. Kasner, MD, has extensive experience conducting multi-center stroke clinical trials, and has been a leading enroller for the current NIH StrokeNet. The PRSTNCC infrastructure supports efficient and effective conduct of stroke trials among the participant hospitals. Research support and expertise are provided by the Hub, particularly in the areas of human subjects protections and other regulatory activities, and education and orientation of clinical and research staff in an effort to streamline trial implementation and expedite patient enrollment. The Hub provides ongoing support for data collection and transfer during trial execution, and provides timely feedback and education about trial results to member specialists and hospitals to encourage translation of research results into clinical practice. In addition, we are training a new generation of stroke researchers in the conduct and design of clinical trials by providing them with the knowledge and skills necessary for a successful academic career as independently-funded clinician-scientists.

费城地区卒中试验网络协调中心 (PRSTNCC) 是一个高效的中风协作研究小组由成人和儿童血管神经科医生、神经外科医生、神经放射科医生、急诊科医生、康复专家和其他进行临床试验的专家专注于中风的治疗、预防和康复。 PRSTNCC 设在大学宾夕法尼亚州 (Penn) 是位于宾夕法尼亚州费城的一个城市三级护理学术医疗中心，该联盟的“枢纽”，并与费城儿童医院 (CHOP) 和 8 其他成员医院（“辐条医院”）位于境内及周边地区和种族不同的地区费城（以及罗德岛州 1 个）。 PRSTNCC 从而将综合卒中中心、初级卒中中心联合起来中风中心和地区儿科中心，为广大中风患者提供就诊服务由临床医生和研究人员组成的多学科小组。 PRSTNCC 的总体目标是减少通过跨学科研究，评估该地区所有年龄和背景的患者的中风负担对中风治疗、预防和康复有希望的临床干预措施的试验。由首席研究员 (PI) Scott E. Kasner 医学博士领导的多学科 PRSTNCC 领导团队已在进行多中心卒中临床试验方面拥有丰富的经验，并且一直是该项目的主要招募者当前的 NIH StrokeNet。 PRSTNCC 基础设施支持高效且有效地进行中风试验参与医院中。该中心提供研究支持和专业知识，特别是在人类受试者保护和其他监管活动以及临床教育和指导领域和研究人员，努力简化试验实施并加快患者入组。枢纽为试验执行过程中的数据收集和传输提供持续支持，并提供及时反馈向会员专家和医院提供有关试验结果的教育，以鼓励研究成果转化结果进入临床实践。此外，我们正在培训新一代中风研究人员进行和设计临床试验，为他们提供成功所需的知识和技能作为独立资助的临床医生科学家的学术生涯。